Jonathan Krog
YOU?
Author Swipe
View article: Deep mapping of the TCR-antigen interface using pMHC-pseudotyped viruses and yeast display
Deep mapping of the TCR-antigen interface using pMHC-pseudotyped viruses and yeast display Open
T cell receptor (TCR) specificity is central to the efficacy of T cell therapies, yet scalable methods to map how TCR sequences shape antigen recognition remain limited. To address this, we introduce VelociRAPTR, a library-on-library appro…
View article: Machine learning model interpretations explain T cell receptor binding
Machine learning model interpretations explain T cell receptor binding Open
T cells mediate immune responses against pathogens and cancer through T cell receptors (TCRs) that recognize foreign peptides presented on the cell surface by Major Histocompatibility Complex (MHC) proteins. TCRs carry enormous diversity a…
View article: Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution
Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution Open
Severe COVID-19 is accompanied by rampant immune dysregulation in the lung and periphery, with immune cells of both compartments contributing to systemic distress. The extent to which immune cells of the lung and blood enter similar or dis…
View article: Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution
Dissecting the common and compartment-specific features of COVID-19 severity in the lung and periphery with single-cell resolution Open
As the global COVID-19 pandemic continues to escalate, no effective treatment has yet been developed for the severe respiratory complications of this disease. This may be due in large part to the unclear immunopathological basis for the de…
View article: Optimality of the spontaneous prophage induction rate
Optimality of the spontaneous prophage induction rate Open
Lysogens are bacterial cells that have survived after being infected by bacterial viruses called bacteriophages. Instead of being killed by the virus, the infected cell survives by integrating the viral DNA into its own genome. This is onl…