Jonathan Lellouche
YOU?
Author Swipe
View article: Virulence factors are preserved within carbapenem-resistant <i>Acinetobacter baumannii</i> clades
Virulence factors are preserved within carbapenem-resistant <i>Acinetobacter baumannii</i> clades Open
Carbapenem-resistant Acinetobacter baumannii (CRAB) is an important threat to hospitalized patients. The virulence of A. baumannii varies between strains and geographic locations, which is believed to be related to its genetic plasticity. …
View article: Integration of individual preclinical and clinical anti‐infective PKPD data to predict clinical study outcomes
Integration of individual preclinical and clinical anti‐infective PKPD data to predict clinical study outcomes Open
The AIDA randomized clinical trial found no significant difference in clinical failure or survival between colistin monotherapy and colistin–meropenem combination therapy in carbapenem‐resistant Gram‐negative infections. The aim of this re…
View article: Carbapenem-resistant <i>Acinetobacter baumannii</i> carrier detection: a simple and efficient protocol
Carbapenem-resistant <i>Acinetobacter baumannii</i> carrier detection: a simple and efficient protocol Open
Timely detection of carbapenem-resistant Acinetobacter baumannii (CRAB) carriers is essential to direct infection control measures. In this work, we aimed to develop a practical protocol to detect CRAB from screening samples. To choose a s…
View article: Hospital-Onset and Community Delta and Omicron SARS-CoV-2 Infections
Hospital-Onset and Community Delta and Omicron SARS-CoV-2 Infections Open
BACKGROUND: Previous studies indicated an increased risk of hospital-onset SARS-CoV-2 infections during the Delta and Omicron waves. Limitations in past research included the failure to compare hospital and general population infection rat…
View article: Nationwide Outbreak of <i>Candida auris</i> Infections Driven by COVID-19 Hospitalizations, Israel, 2021–20221
Nationwide Outbreak of <i>Candida auris</i> Infections Driven by COVID-19 Hospitalizations, Israel, 2021–20221 Open
We report an outbreak of Candida auris across multiple healthcare facilities in Israel. For the period of May 2014-May 2022, a total of 209 patients with C. auris infection or colonization were identified. The C. auris incidence rate incre…
View article: Prevalence and Clinical Consequences of Colistin Heteroresistance and Evolution into Full Resistance in Carbapenem-Resistant Acinetobacter baumannii
Prevalence and Clinical Consequences of Colistin Heteroresistance and Evolution into Full Resistance in Carbapenem-Resistant Acinetobacter baumannii Open
To our knowledge, this is the first large-scale study to report on HR in Gram-negative bacteria. We described the prevalence of colistin HR in a large sample of carbapenem-resistant A. baumannii isolates, the evolution of many colistin HR …
View article: ICE volume 43 issue 6 Cover and Front matter
ICE volume 43 issue 6 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Carriage of vancomycin-resistant <i>Enterococcus faecium</i> in infants following an outbreak in the neonatal intensive care unit: time to clearance of carriage and use of molecular methods to detect colonization
Carriage of vancomycin-resistant <i>Enterococcus faecium</i> in infants following an outbreak in the neonatal intensive care unit: time to clearance of carriage and use of molecular methods to detect colonization Open
Among 46 infants colonized with vancomycin-resistant Enterococcus faecium during an outbreak in a neonatal intensive care unit, the estimated time until half had achieved clearance was 217 days. All 40 infants who completed follow-up clear…
View article: High Rates of Bacterial Pulmonary Co-Infections and Superinfections Identified by Multiplex PCR among Critically Ill COVID-19 Patients
High Rates of Bacterial Pulmonary Co-Infections and Superinfections Identified by Multiplex PCR among Critically Ill COVID-19 Patients Open
Background: The role of bacterial co-infection and superinfection among critically ill COVID-19 patients remains unclear. The aim of this study was to assess the rates and characteristics of pulmonary infections, and associated outcomes of…
View article: High rate of bacterial respiratory tract co-infections upon admission amongst moderate to severe COVID-19 patients
High rate of bacterial respiratory tract co-infections upon admission amongst moderate to severe COVID-19 patients Open
Bacterial co-infection is common amongst moderate-critical COVID-19 patients on admission while viral and atypical bacteria were exceedingly rare. Positive FilmArray results could trigger potentially unnecessary antibiotic treatment.KEY PO…
View article: OXA-900, a Novel OXA Sub-Family Carbapenemase Identified in Citrobacter freundii, Evades Detection by Commercial Molecular Diagnostics Tests
OXA-900, a Novel OXA Sub-Family Carbapenemase Identified in Citrobacter freundii, Evades Detection by Commercial Molecular Diagnostics Tests Open
Using whole-genome sequencing and cloning of the target gene, we identified blaOXA-900 carbapenemase, a novel blaOXA belonging to a distant and distinct sub-family of blaOXA-48-like. The plasmid-mediated gene was identified in a C. freundi…
View article: Occurrence of BNT162b2 Vaccine Adverse Reactions Is Associated with Enhanced SARS-CoV-2 IgG Antibody Response
Occurrence of BNT162b2 Vaccine Adverse Reactions Is Associated with Enhanced SARS-CoV-2 IgG Antibody Response Open
Promoting SARS-CoV-2 vaccination has been a global mission since the first vaccines were approved for emergency use. Alongside the excitement following the possibility of eradicating SARS-CoV-2 and ending the COVID-19 pandemic, there has b…
View article: Increased Capsule Thickness and Hypermotility Are Traits of Carbapenem-Resistant <i>Acinetobacter baumannii</i> ST3 Strains Causing Fulminant Infection
Increased Capsule Thickness and Hypermotility Are Traits of Carbapenem-Resistant <i>Acinetobacter baumannii</i> ST3 Strains Causing Fulminant Infection Open
Background Acinetobacter baumannii is a successful nosocomial pathogen, causing severe, life-threatening infections in hospitalized patients, including pneumonia and bloodstream infections. The spread of carbapenem-resistant Acinetobacter …
View article: Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018
Epidemiological, clinical and laboratory features of acute Q fever in a cohort of hospitalized patients in a regional hospital, Israel, 2012-2018 Open
Introduction Acute Q fever is endemic in Israel, yet the clinical and laboratory picture is poorly defined. Methods A retrospective study reviewing the medical records of acute Q fever patients, conducted in a single hospital in the Sharon…
View article: Multiplex Lateral Flow Immunochromatographic Assay Is an Effective Method to Detect Carbapenemases Without Risk of OXA-48-like Cross Reactivity
Multiplex Lateral Flow Immunochromatographic Assay Is an Effective Method to Detect Carbapenemases Without Risk of OXA-48-like Cross Reactivity Open
Background : It is essential to detect carriers of carbapenemase-producing Enterobacterales in order to implement infection control measures. The objectives of this study was to evaluate the NG-Test® CARBA 5 (CARBA 5) assay for detection o…
View article: Comparing Efficacy of Common Pocket Irrigation Protocols in an Infected Breast Implant Model
Comparing Efficacy of Common Pocket Irrigation Protocols in an Infected Breast Implant Model Open
INTRODUCTION: Infection of breast implants is a leading cause for explantation. Contamination of implants may persist over time in the form of biofilm and is extremely difficult to eradicate. This has prompted the development of various pe…
View article: Detecting carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) carriage: Which body site should be cultured?
Detecting carbapenem-resistant <i>Acinetobacter baumannii</i> (CRAB) carriage: Which body site should be cultured? Open
We compared the yield of culturing various body sites to detect carriage of carbapenem-resistant Acinetobacter baumannii (CRAB). Culturing the skin using a premoistened sponge, with overnight enrichment and plating on CHROMagar MDR Acineto…
View article: In vivo Fitness of Acinetobacter baumannii Strains in Murine Infection Is Associated with International Lineage II-rep-2 and International Lineage III Clones Showing High Case Fatality Rates in Human Infections
In vivo Fitness of Acinetobacter baumannii Strains in Murine Infection Is Associated with International Lineage II-rep-2 and International Lineage III Clones Showing High Case Fatality Rates in Human Infections Open
We previously reported that the 14-day case fatality rate (CFR) in patients with carbapenem-resistant Acinetobacter baumannii (CRAB) bacteremia varied between infecting clones. Here, we evaluated the in vitro and in vivo fitness of CRAB bl…
View article: Fourier Transform Infrared Spectroscopy Is a New Option for Outbreak Investigation: a Retrospective Analysis of an Extended-Spectrum-Beta-Lactamase-Producing Klebsiella pneumoniae Outbreak in a Neonatal Intensive Care Unit
Fourier Transform Infrared Spectroscopy Is a New Option for Outbreak Investigation: a Retrospective Analysis of an Extended-Spectrum-Beta-Lactamase-Producing Klebsiella pneumoniae Outbreak in a Neonatal Intensive Care Unit Open
The IR Biotyper is a new automated typing system based on Fourier-transform infrared (FT-IR) spectroscopy that gives results within 4 h. We aimed (i) to use the IR Biotyper to retrospectively analyze an outbreak of extended-spectrum beta-l…
View article: Performance of Rapid Polymyxin™ NP and Rapid Polymyxin™ Acinetobacter for the detection of polymyxin resistance in carbapenem-resistant Acinetobacter baumannii and Enterobacterales
Performance of Rapid Polymyxin™ NP and Rapid Polymyxin™ Acinetobacter for the detection of polymyxin resistance in carbapenem-resistant Acinetobacter baumannii and Enterobacterales Open
Background The global spread of carbapenem-resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB) has prompted the reintroduction of colistin as a last-resort treatment. Although the recommended method for colistin susceptibil…