Jonathan Lezmy
YOU?
Author Swipe
Astrocyte Ca <sup>2+</sup> activity regulates node of Ranvier length in the white matter Open
Nodes of Ranvier generate action potentials along myelinated axons, but it is unclear whether they can modulate neural circuit function. Computer modelling previously predicted that adjusting node length can control axonal conduction speed…
Developmental shaping of node of Ranvier geometry contributes to spike timing maturation in primary auditory afferents Open
Sound is encoded by action potentials in spiral ganglion neurons (SGNs), the auditory afferents from the cochlea. Rapid action potential transmission along SGNs is crucial for quick reactions to sounds, and binaural differences in action p…
Homeostatic plasticity of axonal excitable sites in Alzheimer's disease Open
OPINION article Front. Neurosci., 23 October 2023Sec. Neurodegeneration Volume 17 - 2023 | https://doi.org/10.3389/fnins.2023.1277251
How astrocytic ATP shapes neuronal activity and brain circuits Open
Astrocytes play a key role in processing information at synapses, by controlling synapse formation, modulating synapse strength and terminating neurotransmitter action. They release ATP to shape brain activity but it is unclear how, as ast…
Excitatory and inhibitory hippocampal neurons differ in their homeostatic adaptation to chronic M-channel modulation Open
A large body of studies has investigated bidirectional homeostatic plasticity both in vitro and in vivo using numerous pharmacological manipulations of activity or behavioral paradigms. However, these experiments rarely explored in the sam…
Astrocyte Ca <sup>2+</sup> -evoked ATP release regulates myelinated axon excitability and conduction speed Open
Glia control white matter information flow The myelinated axons of the white matter mediate rapid information transmission between the brain’s processing nodes. Axonal excitability and conduction speed are key determinants of neural circui…
M-Current Inhibition in Hippocampal Excitatory Neurons Triggers Intrinsic and Synaptic Homeostatic Responses at Different Temporal Scales Open
Persistent alterations in neuronal activity elicit homeostatic plastic changes in synaptic transmission and/or intrinsic excitability. However, it is unknown whether these homeostatic processes operate in concert or at different temporal s…
M-current inhibition rapidly induces a unique CK2-dependent plasticity of the axon initial segment Open
Significance The axon initial segment (AIS), the region where neurons generate spikes, was recently shown to be a highly dynamic structure, exhibiting plasticity over wide timescales. Here we triggered a unique form of AIS plasticity in hi…