Jonathan M. Chernus
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View article: Genetic Variation in the Alternative Complement Pathway Contributes to Individual Susceptibility to Bacteremia and Sepsis
Genetic Variation in the Alternative Complement Pathway Contributes to Individual Susceptibility to Bacteremia and Sepsis Open
IMPORTANCE: The alternative complement pathway is a key component of host defense against bacteremia and other infections. However, dysregulated activation can contribute to excessive inflammation and worse clinical outcomes during bactere…
View article: Limb development genes underlie variation in human fingerprint patterns
Limb development genes underlie variation in human fingerprint patterns Open
Fingerprints are of long-standing practical and cultural interest, but little is known about the mechanisms that underlie their variation. Using genome-wide scans in Han Chinese cohorts, we identified 18 loci associated with fingerprint ty…
View article: Association of Early Childhood Caries with Bitter Taste Receptors: A Meta-Analysis of Genome-Wide Association Studies and Transcriptome-Wide Association Study
Association of Early Childhood Caries with Bitter Taste Receptors: A Meta-Analysis of Genome-Wide Association Studies and Transcriptome-Wide Association Study Open
Although genetics affects early childhood caries (ECC) risk, few studies have focused on finding its specific genetic determinants. Here, we performed genome-wide association studies (GWAS) in five cohorts of children (aged up to 5 years, …
View article: Genome-wide Scan of Dental Fear and Anxiety Nominates Novel Genes
Genome-wide Scan of Dental Fear and Anxiety Nominates Novel Genes Open
Dental care–related fear and anxiety (DFA) is prevalent, affects oral health care utilization, and is related to poor oral health and decreased quality of life. In addition to learned and cultural factors, genetics is hypothesized to contr…
View article: Genome-Wide Association Study (GWAS) of dental caries in diverse populations
Genome-Wide Association Study (GWAS) of dental caries in diverse populations Open
Background Dental caries is one of the most common chronic diseases and is influenced by a complex interplay of genetic and environmental factors. Most previous genetic studies of caries have focused on identifying genes that contribute to…
View article: A candidate gene analysis and GWAS for genes associated with maternal nondisjunction of chromosome 21
A candidate gene analysis and GWAS for genes associated with maternal nondisjunction of chromosome 21 Open
Human nondisjunction errors in oocytes are the leading cause of pregnancy loss, and for pregnancies that continue to term, the leading cause of intellectual disabilities and birth defects. For the first time, we have conducted a candidate …
View article: Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome
Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome Open
The authors report the interaction between Down syndrome, a major genetic leukemia predisposition condition, and inherited genetic alleles associated with increased susceptibility to childhood acute lymphoblastic leukemia.
View article: GWAS reveals loci associated with velopharyngeal dysfunction
GWAS reveals loci associated with velopharyngeal dysfunction Open
Velopharyngeal dysfunction (VPD) occurs when the muscular soft palate (velum) and lateral pharyngeal walls are physically unable to separate the oral and nasal cavities during speech production leading to hypernasality and abnormal speech …
View article: A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain
A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain Open
Background . Acute and chronic orofacial pain can significantly impact overall health and functioning. Associations between fear of pain and the experience of orofacial pain are well-documented, and environmental, behavioral, and cognitive…