Jonathan M. Cordeiro
YOU?
Author Swipe
View article: Identification and characterization of two novel KCNH2 mutations contributing to long QT syndrome
Identification and characterization of two novel KCNH2 mutations contributing to long QT syndrome Open
We identified two different inherited mutations in KCNH2 gene, or human ether-a-go-go related gene (hERG), which are linked to Long QT Syndrome. The first mutation was in a 1-day-old infant, whereas the second was in a 14-year-old girl. Th…
View article: Overlap Arrhythmia Syndromes Resulting from Multiple Genetic Variations Studied in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Overlap Arrhythmia Syndromes Resulting from Multiple Genetic Variations Studied in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Open
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are used for genetic models of cardiac diseases. We report an arrhythmia syndrome consisting of Early Repolarization Syndrome (ERS) and Short QT Syndrome (SQTS). The in…
View article: An in silico hiPSC-Derived Cardiomyocyte Model Built With Genetic Algorithm
An in silico hiPSC-Derived Cardiomyocyte Model Built With Genetic Algorithm Open
The formulation of in silico biophysical models generally requires optimization strategies for reproducing experimentally observed phenomena. In electrophysiological modeling, robust nonlinear regressive methods are often crucial for guara…
View article: Data-Driven Uncertainty Quantification for Cardiac Electrophysiological Models: Impact of Physiological Variability on Action Potential and Spiral Wave Dynamics
Data-Driven Uncertainty Quantification for Cardiac Electrophysiological Models: Impact of Physiological Variability on Action Potential and Spiral Wave Dynamics Open
Computational modeling of cardiac electrophysiology (EP) has recently transitioned from a scientific research tool to clinical applications. To ensure reliability of clinical or regulatory decisions made using cardiac EP models, it is vita…
View article: Susceptibility to Ventricular Arrhythmias Resulting from Mutations in <i>FKBP1B</i>, <i>PXDNL</i>, and <i>SCN9A</i> Evaluated in hiPSC Cardiomyocytes
Susceptibility to Ventricular Arrhythmias Resulting from Mutations in <i>FKBP1B</i>, <i>PXDNL</i>, and <i>SCN9A</i> Evaluated in hiPSC Cardiomyocytes Open
Background . We report an inherited cardiac arrhythmia syndrome consisting of Brugada and Early Repolarization Syndrome associated with variants in SCN9A , PXDNL , and FKBP1B . The proband inherited the 3 mutations and exhibited palpitatio…
View article: Genetic Algorithm For Fitting Cardiac Cell Biophysical Model Formulations
Genetic Algorithm For Fitting Cardiac Cell Biophysical Model Formulations Open
Modeling cardiac cell electrophysiology relies on fitting model equations to experimental data obtained under voltage/current clamping conditions. The fitting procedure for these often-nonlinear ionic current equations are mostly executed …
View article: Triggered Ca <sup>2+</sup> Waves Induce Depolarization of Maximum Diastolic Potential and Action Potential Prolongation in Dog Atrial Myocytes
Triggered Ca <sup>2+</sup> Waves Induce Depolarization of Maximum Diastolic Potential and Action Potential Prolongation in Dog Atrial Myocytes Open
Background: We have identified a novel form of abnormal Ca 2+ wave activity in normal and failing dog atrial myocytes which occurs during the action potential (AP) and is absent during diastole. The goal of this study was to determine if t…
View article: Comprehensive Uncertainty Quantification and Sensitivity Analysis for Cardiac Action Potential Models
Comprehensive Uncertainty Quantification and Sensitivity Analysis for Cardiac Action Potential Models Open
Recent efforts to ensure the reliability of computational model-based predictions in healthcare, such as the ASME V&V40 Standard, emphasize the importance of uncertainty quantification (UQ) and sensitivity analysis (SA) when evaluating com…
View article: Functional Role of T-tubules on Calcium Transients in Canine Cardiac Myocytes
Functional Role of T-tubules on Calcium Transients in Canine Cardiac Myocytes Open
Background: A loss of t-tubules and alterations in ultrastructure occur in cultured ventricular myocytes. A similar alteration in t-tubules and ultrastructure is well documented under certain pathological conditions such as heart failure. …
View article: Interventricular differences in sodium current and its potential role in Brugada syndrome
Interventricular differences in sodium current and its potential role in Brugada syndrome Open
Brugada syndrome (BrS) is an inherited disease associated with ST elevation in the right precordial leads, polymorphic ventricular tachycardia (PVT), and sudden cardiac death in adults. Mutations in the cardiac sodium channel account for a…
View article: Triggered intracellular calcium waves in dog and human left atrial myocytes from normal and failing hearts
Triggered intracellular calcium waves in dog and human left atrial myocytes from normal and failing hearts Open
TCWs develop during the atrial AP and thus could affect AP duration, producing repolarization gradients and creating a substrate for reentry, particularly in HF where they develop at slower rates and a higher incidence. TCWs may represent …