Jonathan M. Zuidema
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View article: Nanomaterial payload delivery to central nervous system glia for neural protection and repair
Nanomaterial payload delivery to central nervous system glia for neural protection and repair Open
Central nervous system (CNS) glia, including astrocytes, microglia, and oligodendrocytes, play prominent roles in traumatic injury and degenerative disorders. Due to their importance, active pharmaceutical ingredients (APIs) are being deve…
View article: Inorganic nanoparticle empowered biomaterial hybrids: Engineered payload release
Inorganic nanoparticle empowered biomaterial hybrids: Engineered payload release Open
There are many challenges in delivering active pharmaceutical ingredients from biomaterials, including retention of payload activity, accurate temporal release, and precise spatial administration, to name only a few. With our constantly in…
View article: Porous Silicon Nanoparticles Targeted to the Extracellular Matrix for Therapeutic Protein Delivery in Traumatic Brain Injury
Porous Silicon Nanoparticles Targeted to the Extracellular Matrix for Therapeutic Protein Delivery in Traumatic Brain Injury Open
Traumatic brain injury (TBI) is a major cause of disability and death among children and young adults in the United States, yet there are currently no treatments that improve the long-term brain health of patients. One promising therapeuti…
View article: Anti-KIT DNA aptamer-conjugated porous silicon nanoparticles for the targeted detection of gastrointestinal stromal tumors
Anti-KIT DNA aptamer-conjugated porous silicon nanoparticles for the targeted detection of gastrointestinal stromal tumors Open
A preclinical mouse model for in vivo imaging of Gastrointestinal Stromal Tumors (GIST) using KIT-aptamer targeted fluorescently-labeled porous silicon nanoparticles.
View article: Tuning the Loading and Release Properties of MicroRNA-Silencing Porous Silicon Nanoparticles by Using Chemically Diverse Peptide Nucleic Acid Payloads
Tuning the Loading and Release Properties of MicroRNA-Silencing Porous Silicon Nanoparticles by Using Chemically Diverse Peptide Nucleic Acid Payloads Open
Peptide nucleic acids (PNAs) are a class of artificial oligonucleotide mimics that have garnered much attention as precision biotherapeutics for their efficient hybridization properties and their exceptional biological and chemical stabili…
View article: Enteric Polymer-Coated Porous Silicon Nanoparticles for Site-Specific Oral Delivery of IgA Antibody
Enteric Polymer-Coated Porous Silicon Nanoparticles for Site-Specific Oral Delivery of IgA Antibody Open
Porous silicon (pSi) nanoparticles are loaded with Immunoglobulin A-2 (IgA2) antibodies, and the assembly is coated with pH-responsive polymers on the basis of the Eudragit family of enteric polymers (L100, S100, and L30-D55). The temporal…
View article: Biomaterial strategies for creating in vitro astrocyte cultures resembling in vivo astrocyte morphologies and phenotypes
Biomaterial strategies for creating in vitro astrocyte cultures resembling in vivo astrocyte morphologies and phenotypes Open
View article: Porous Silicon Nanoparticles Embedded in Poly(lactic‐<i>co</i>‐glycolic acid) Nanofiber Scaffolds Deliver Neurotrophic Payloads to Enhance Neuronal Growth
Porous Silicon Nanoparticles Embedded in Poly(lactic‐<i>co</i>‐glycolic acid) Nanofiber Scaffolds Deliver Neurotrophic Payloads to Enhance Neuronal Growth Open
Scaffolds made from biocompatible polymers provide physical cues to direct the extension of neurites and to encourage repair of damaged nerves. The inclusion of neurotrophic payloads in these scaffolds can substantially enhance regrowth an…
View article: Hybrid polymer/porous silicon nanofibers for loading and sustained release of synthetic DNA-based responsive devices
Hybrid polymer/porous silicon nanofibers for loading and sustained release of synthetic DNA-based responsive devices Open
Synthetic DNA-based oligonucleotides are loaded into porous silicon nanoparticles and incorporated into polymer nanofibers. The functionality of these input-responsive nanodevices is retained following release from the hybrid nanofibers.
View article: Tumor-Targeting, MicroRNA-Silencing Porous Silicon Nanoparticles for Ovarian Cancer Therapy
Tumor-Targeting, MicroRNA-Silencing Porous Silicon Nanoparticles for Ovarian Cancer Therapy Open
Silencing of aberrantly expressed microRNAs (miRNAs or miRs) has emerged as one of the strategies for molecular targeted cancer therapeutics. In particular, miR-21 is an oncogenic miRNA overexpressed in many tumors, including ovarian cance…
View article: Injectable, Magnetically Orienting Electrospun Fiber Conduits for Neuron Guidance
Injectable, Magnetically Orienting Electrospun Fiber Conduits for Neuron Guidance Open
Magnetic electrospun fibers are of interest for minimally invasive biomaterial applications that also strive to provide cell guidance. Magnetic electrospun fibers can be injected and then magnetically positioned in situ, and the aligned fi…
View article: The Effect of Electrospun Fiber Diameter on Astrocyte-Mediated Neurite Guidance and Protection
The Effect of Electrospun Fiber Diameter on Astrocyte-Mediated Neurite Guidance and Protection Open
The topography of electrospun fiber scaffolds modifies astrocytes toward in vivo-like morphologies and behaviors. However, little is known about how electrospun fiber diameter influences astrocyte behavior. In this work, aligned fib…
View article: Enhanced Performance of a Molecular Photoacoustic Imaging Agent by Encapsulation in Mesoporous Silicon Nanoparticles
Enhanced Performance of a Molecular Photoacoustic Imaging Agent by Encapsulation in Mesoporous Silicon Nanoparticles Open
Photoacoustic (PA) imaging allows visualization of the physiology and pathology of tissues with good spatial resolution and relatively deep tissue penetration. The method converts near‐infrared (NIR) laser excitation into thermal expansion…
View article: Oriented Nanofibrous Polymer Scaffolds Containing Protein‐Loaded Porous Silicon Generated by Spray Nebulization
Oriented Nanofibrous Polymer Scaffolds Containing Protein‐Loaded Porous Silicon Generated by Spray Nebulization Open
Oriented composite nanofibers consisting of porous silicon nanoparticles (pSiNPs) embedded in a polycaprolactone or poly(lactide‐ co ‐glycolide) matrix are prepared by spray nebulization from chloroform solutions using an airbrush. The nan…
View article: Biomaterial Approaches to Modulate Reactive Astroglial Response
Biomaterial Approaches to Modulate Reactive Astroglial Response Open
Over several decades, biomaterial scientists have developed materials to spur axonal regeneration and limit secondary injury and tested these materials within preclinical animal models. Rarely, though, are astrocytes examined comprehensive…
View article: Two‐Photon In Vivo Imaging with Porous Silicon Nanoparticles
Two‐Photon In Vivo Imaging with Porous Silicon Nanoparticles Open
A major obstacle in luminescence imaging is the limited penetration of visible light into tissues and interference associated with light scattering and autofluorescence. Near‐infrared (NIR) emitters that can also be excited with NIR radiat…
View article: Facile Surface Modification of Hydroxylated Silicon Nanostructures Using Heterocyclic Silanes
Facile Surface Modification of Hydroxylated Silicon Nanostructures Using Heterocyclic Silanes Open
Heterocyclic silanes containing Si-N or Si-S bonds in the ring undergo a ring opening reaction with -OH groups at the surface of porous Si nanostructures to generate -SH or -NH functional surfaces, grafted via O-Si bonds. The reaction is s…
View article: Robust neurite extension following exogenous electrical stimulation within single walled carbon nanotube-composite hydrogels
Robust neurite extension following exogenous electrical stimulation within single walled carbon nanotube-composite hydrogels Open
View article: Title Page / Table of Contents
Title Page / Table of Contents Open
View article: Author and Subject Index Vol. 202, No. 1-2, 2015/2016
Author and Subject Index Vol. 202, No. 1-2, 2015/2016 Open
View article: Matrix compliance and the regulation of cytokinesis
Matrix compliance and the regulation of cytokinesis Open
Integrin-mediated cell adhesion to the ECM regulates many physiological processes in part by controlling cell proliferation. It is well established that many normal cells require integrin-mediated adhesion to enter S phase of the cell cycl…
View article: Astrocytes Increase ATP Exocytosis Mediated Calcium Signaling in Response to Microgroove Structures
Astrocytes Increase ATP Exocytosis Mediated Calcium Signaling in Response to Microgroove Structures Open
View article: Nebulized solvent ablation of aligned PLLA fibers for the study of neurite response to anisotropic-to-isotropic fiber/film transition (AFFT) boundaries in astrocyte–neuron co-cultures
Nebulized solvent ablation of aligned PLLA fibers for the study of neurite response to anisotropic-to-isotropic fiber/film transition (AFFT) boundaries in astrocyte–neuron co-cultures Open