Jonathan McConathy
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View article: PET Imaging of CD38 and IND enabling studies of [89Zr]Zr-DFO-Isatuximab
PET Imaging of CD38 and IND enabling studies of [89Zr]Zr-DFO-Isatuximab Open
Background CD38 is an excellent biomarker and therapeutic target for multiple myeloma due to its high expression on cancerous cells in comparison to healthy cells. Purpose We aimed to adapt Isatuximab as a PET imaging agent to detect CD38 …
View article: Calibration of multi‐site raters for prospective visual read of amyloid PET scans acquired across the ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI)
Calibration of multi‐site raters for prospective visual read of amyloid PET scans acquired across the ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI) Open
Background PET visual reads for multi‐center studies are conducted centrally by one or a few experts. In CLARiTI, a broader network of raters will perform the reads, necessitating methods to ensure their accuracy and reliability. Method Al…
View article: The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI): Overview of consortium sites and anticipated enrollment
The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI): Overview of consortium sites and anticipated enrollment Open
INTRODUCTION The Consortium for Clarity in Alzheimer's disease related dementias (ADRD) Research Through Imaging (CLARiTI) is a study that aims to collect standardized imaging and plasma biomarkers on 2000 Clinical Core participants enroll…
View article: IMG-133. System L amino acid ([F-18]FET) and hypoxia ([F-18]FMISO) PET/MRI to assess early response after completion of radiation therapy in high grade glioma
IMG-133. System L amino acid ([F-18]FET) and hypoxia ([F-18]FMISO) PET/MRI to assess early response after completion of radiation therapy in high grade glioma Open
PURPOSE This ongoing study aims to determine 1) the frequency of PET positivity for high grade glioma (HGG) early after completion of radiation therapy (RT) using the amino acid [F-18]FET and 2) the relationships between [F-18]FET uptake a…
View article: Calibration of multisite raters for prospective visual reads of amyloid PET scans
Calibration of multisite raters for prospective visual reads of amyloid PET scans Open
INTRODUCTION In multicenter Alzheimer's disease studies, amyloid positron emission tomography (PET) visual reads are typically performed centrally by a few experts. Incorporating a broader reader network enhances scalability and generaliza…
View article: Update to the RANO working group and EANO recommendations for the clinical use of PET imaging in gliomas
Update to the RANO working group and EANO recommendations for the clinical use of PET imaging in gliomas Open
This Policy Review provides recommendations for the use of PET imaging in patients with gliomas and represents a joint effort of the Response Assessment in Neuro-Oncology (RANO) working group for PET and the European Association for Neuro-…
View article: Quantitative [<sup>89</sup>Zr]Zr-Trastuzumab PET and Diffusion- Weighted MRI for Characterization of Metastatic HER2-Positive Breast Cancer with PET/MRI
Quantitative [<sup>89</sup>Zr]Zr-Trastuzumab PET and Diffusion- Weighted MRI for Characterization of Metastatic HER2-Positive Breast Cancer with PET/MRI Open
Current methods for evaluating HER2 expression in breast cancer are invasive and fail to capture spatial and temporal heterogeneity between primary tumors and metastases. Nuclear imaging allows for whole-body, noninvasive assessment of hum…
View article: Demonstrating an Academic Core Facility for Automated Medical Image Processing and Analysis: Workflow Design and Practical Applications
Demonstrating an Academic Core Facility for Automated Medical Image Processing and Analysis: Workflow Design and Practical Applications Open
Background/Objectives: Medical research institutions are increasingly leveraging artificial intelligence (AI) to enhance the processing and analysis of medical imaging data. However, scaling AI-driven medical image analysis often requires …
View article: PET Imaging Expedites Detection of Aberration in the Humanization of an Annexin A1 Targeting Antibody
PET Imaging Expedites Detection of Aberration in the Humanization of an Annexin A1 Targeting Antibody Open
Objectives: Annexin-A1 is a 37 kDa phospholipid-binding protein which is concentrated in a truncated 34 kDa form (AnnA1) in caveolae on the tumor vascular endothelial cell surface with expression in many tumor types. PRISM developed the mo…
View article: SNMMI Procedure Standard/EANM Practice Guideline for Fibroblast Activation Protein (FAP) PET
SNMMI Procedure Standard/EANM Practice Guideline for Fibroblast Activation Protein (FAP) PET Open
Contains fulltext : 318481.pdf (Publisher’s version ) (Open Access)
View article: l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models
l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models Open
Tumor cells are known to undergo considerable metabolic reprogramming to meet their unique demands and drive tumor growth. At the same time, this reprogramming may come at a cost with resultant metabolic vulnerabilities. The small molecule…
View article: Gene expression and ultra-structural evidence for metabolic derangement in the primary mitral regurgitation heart
Gene expression and ultra-structural evidence for metabolic derangement in the primary mitral regurgitation heart Open
Aims Chronic neurohormonal activation and haemodynamic load cause derangement in the utilization of the myocardial substrate. In this study, we test the hypothesis that the primary mitral regurgitation (PMR) heart shows an altered metaboli…
View article: Introducing the American Society of Neuroradiology PET-Guided Diagnosis and Management in Neuro-Oncology Study Group
Introducing the American Society of Neuroradiology PET-Guided Diagnosis and Management in Neuro-Oncology Study Group Open
The American Society of Neuroradiology (ASNR) is pleased to introduce its latest initiative: the PET-Guided Diagnosis and Management in Neuro-Oncology Study Group. This group will focus on leveraging molecular imaging and theranostics to e…
View article: Imaging With PET/CT of Diffuse CD8 T-Cell Infiltration of Skeletal Muscle in Patients With Inclusion Body Myositis
Imaging With PET/CT of Diffuse CD8 T-Cell Infiltration of Skeletal Muscle in Patients With Inclusion Body Myositis Open
89Zr-Df-crefmirlimab uptake in muscles of patients with IBM was present at an intensity greater than the comparator population. The ability to visualize whole body in vivo cytotoxic T-cell tissue infiltration in the autoimmune disease IBM …
View article: Evidence of neuroinflammation in fibromyalgia syndrome: a [18F]DPA-714 positron emission tomography study
Evidence of neuroinflammation in fibromyalgia syndrome: a [18F]DPA-714 positron emission tomography study Open
This observational study aimed to determine whether individuals with fibromyalgia (FM) exhibit higher levels of neuroinflammation than healthy controls (HCs), as measured with positron emission tomography using [ 18 F]DPA-714, a second-gen…
View article: Prediction of MCI-to-AD progression with atrophy-weighted standard uptake value ratios of<sup>18</sup>F-Florbetapir PET
Prediction of MCI-to-AD progression with atrophy-weighted standard uptake value ratios of<sup>18</sup>F-Florbetapir PET Open
Accurate prediction of MCI-to-AD progression is an important yet challenging task. We introduce a new quantitative parameter: the atrophy-weighted standard uptake value ratio (awSUVR), defined as the PET SUVR divided by the hippocampal vol…
View article: Brain and Systemic Inflammation in De Novo Parkinson's Disease
Brain and Systemic Inflammation in De Novo Parkinson's Disease Open
Objective To assess the presence of brain and systemic inflammation in subjects newly diagnosed with Parkinson's disease (PD). Background Evidence for a pathophysiologic role of inflammation in PD is growing. However, several key gaps rema…
View article: 1472 Assessing the correlation between CD8 cell PET Imaging with 89-Zr-Crefmirlimab Berdoxam and CD8 cell immunohistochemistry in patients with advanced cancer receiving immunotherapy
1472 Assessing the correlation between CD8 cell PET Imaging with 89-Zr-Crefmirlimab Berdoxam and CD8 cell immunohistochemistry in patients with advanced cancer receiving immunotherapy Open
Background CD8 T-cells (CD8s) mediate the effects of most cancer immunotherapies. CD8s are typically assessed by biopsy which is inherently limited by sample availability, intratumoral and intrapatient heterogeneity, and difficulty with re…
View article: Brain and systemic inflammation in <i>de novo</i> Parkinson’s disease
Brain and systemic inflammation in <i>de novo</i> Parkinson’s disease Open
Objective To assess the presence of brain and systemic inflammation in subjects newly diagnosed with Parkinson’s disease (PD). Background Evidence for a pathophysiologic role of inflammation in PD is growing. However, several key gaps rema…
View article: Investigating Tau and Amyloid Tracer Skull Binding in Studies of Alzheimer Disease
Investigating Tau and Amyloid Tracer Skull Binding in Studies of Alzheimer Disease Open
Off-target binding of [18F]flortaucipir (FTP) can complicate quantitative PET analyses. An underdiscussed off-target region is the skull. Here, we characterize how often FTP skull binding occurs, its influence on estimates of Alzheimer dis…
View article: Image Quantification for TSPO PET with a Novel Image-Derived Input Function Method
Image Quantification for TSPO PET with a Novel Image-Derived Input Function Method Open
There is a growing interest in using 18F-DPA-714 PET to study neuroinflammation and microglial activation through imaging the 18-kDa translocator protein (TSPO). Although quantification of 18F-DPA-714 binding can be achieved through kineti…
View article: PET/MRI in Pediatric Neuroimaging: Primer for Clinical Practice
PET/MRI in Pediatric Neuroimaging: Primer for Clinical Practice Open
Modern pediatric imaging seeks to provide not only exceptional anatomic detail but also physiologic and metabolic information of the pathology in question with as little radiation penalty as possible. Hybrid PET/MR imaging combines exquisi…
View article: NCCN Guidelines® Insights: Hodgkin Lymphoma, Version 2.2022
NCCN Guidelines® Insights: Hodgkin Lymphoma, Version 2.2022 Open
Hodgkin lymphoma (HL) is an uncommon malignancy of B-cell origin. Classical HL (cHL) and nodular lymphocyte–predominant HL are the 2 main types of HL. The cure rates for HL have increased so markedly with the advent of modern treatment opt…
View article: Neuroimaging within the Dominantly Inherited Alzheimer’s Network (DIAN): PET and MRI
Neuroimaging within the Dominantly Inherited Alzheimer’s Network (DIAN): PET and MRI Open
The Dominantly Inherited Alzheimer Network (DIAN) Observational Study is an international collaboration studying autosomal dominant Alzheimer disease (ADAD). This rare form of Alzheimer disease (AD) is caused by mutations in the presenilin…
View article: Low-Dose Augmentation With Buprenorphine for Treatment-Resistant Depression: A Multisite Randomized Controlled Trial With Multimodal Assessment of Target Engagement
Low-Dose Augmentation With Buprenorphine for Treatment-Resistant Depression: A Multisite Randomized Controlled Trial With Multimodal Assessment of Target Engagement Open
Our findings suggest a lack of clinical effect of low-dose BPN augmentation and lack of target engagement with this dosage and physiological probes.
View article: A Path to Qualification of PET/MRI Scanners for Multicenter Brain Imaging Studies: Evaluation of MRI-Based Attenuation Correction Methods Using a Patient Phantom
A Path to Qualification of PET/MRI Scanners for Multicenter Brain Imaging Studies: Evaluation of MRI-Based Attenuation Correction Methods Using a Patient Phantom Open
PET/MRI scanners cannot be qualified in the manner adopted for hybrid PET/CT devices. The main hurdle with qualification in PET/MRI is that attenuation correction (AC) cannot be adequately measured in conventional PET phantoms because of t…
View article: Dynamic Amyloid PET: Relationships to <sup>18</sup>F-Flortaucipir Tau PET Measures
Dynamic Amyloid PET: Relationships to <sup>18</sup>F-Flortaucipir Tau PET Measures Open
Measuring amyloid and predicting tau status using a single amyloid PET study would be valuable for assessing brain AD pathophysiology. We hypothesized that early-frame amyloid PET (efAP) correlates with the presence of tau pathology becaus…