Explanipedia

Donor human milk and structural brain development in very preterm infants Open

Katherine M. Ottolini, Sudeepta K. Basu, Julius S. Ngwa, Kushal Kapse, Jonathan Murnick , et al. · 2025

Background We investigated the impact of donor milk on structural brain development, relative to maternal milk feeding, in very preterm infants at term-equivalent age (TEA). Methods Very preterm infants ( ≤32 weeks’ gestation) were enrolle…

Brain metabolite concentrations in neonates with congenital heart disease before and after cardiac surgery Open

Steve C. N. Hui, Nickie Andescavage, Julius S. Ngwa, Kushal Kapse, Jonathan Murnick , et al. · 2025

The purpose of this study was to compare brain metabolite concentrations between healthy and CHD neonates before and after cardiac surgery. Healthy term newborns and neonates with CHD were recruited prospectively. T₂-weighted br…

Early parenteral lipid intake supports cerebellar neurometabolism at term-age in preterm infants Open

Sudeepta K. Basu, Katherine M. Ottolini, Kushal Kapse, Julius S. Ngwa, Steve C. N. Hui , et al. · 2025

Parenteral lipid intake is associated with higher cerebellar NAA and Glx concentrations, supporting brain development in preterm infants.

Brain development using a multicomponent intravenous lipid emulsion in preterm infants Open

Katherine M. Ottolini, Julius S. Ngwa, Sudeepta K. Basu, Kushal Kapse, Melissa Liggett , et al. · 2024

Prenatal Maternal Psychological Distress During the COVID-19 Pandemic and Newborn Brain Development Open

Susan Weiner, Yao Wu, Kushal Kapse, Tracy Moran Vozar, J. Cheng , et al. · 2024

Importance Elevated maternal psychological distress during pregnancy is associated with altered fetal brain development. During the COVID-19 pandemic, prenatal maternal psychological distress more than doubled. Objective To examine the ass…

Cholesteatoma: Canalplasty for External Auditory Stenosis in a Pediatric Patient Open

Amir Elzomor, Marissa Firlie, Nicklas C. Orobello, Jonathan Murnick, Brian K. Reilly · 2023

Experience of early-life pain in premature infants is associated with atypical cerebellar development and later neurodevelopmental deficits Open

Kevin M. Cook, Josepheen De Asis‐Cruz, Jung‐Hoon Kim, Sudeepta K. Basu, Nickie Andescavage , et al. · 2023

Background Infants born very and extremely premature (V/EPT) are at a significantly elevated risk for neurodevelopmental disorders and delays even in the absence of structural brain injuries. These risks may be due to earlier-than-typical …

Impact of bronchopulmonary dysplasia on brain GABA concentrations in preterm infants: Prospective cohort study Open

Sudeepta K. Basu, Kushal Kapse, Jonathan Murnick, Subechhya Pradhan, Emma Spoehr , et al. · 2023

Ex-utero third trimester developmental changes in functional brain network organization in infants born very and extremely preterm Open

Kevin M. Cook, Josepheen De Asis‐Cruz, Sudeepta K. Basu, Nickie Andescavage, Jonathan Murnick , et al. · 2023

Introduction The latter half of gestation is a period of rapid brain development, including the formation of fundamental functional brain network architecture. Unlike in-utero fetuses, infants born very and extremely preterm undergo these …

Starfield Pattern on Brain MRI in a Patient with Duchenne Muscular Dystrophy Open

Vivien X. Xie, Dana Harrar, Jonathan Murnick, Diana Bharucha‐Goebel, Kuntal Sen · 2023

An 18-year-old man with Duchenne muscular dystrophy (DMD) presented with encephalopathy 20 minutes after falling from a sitting position. X-ray of his left femur showed a minimally displaced acute fracture. On initial examination, he was o…

Severity of prematurity and age impact early postnatal development of GABA and glutamate systems Open

Sudeepta K. Basu, Subechhya Pradhan, Yushuf M Sharker, Kushal Kapse, Jonathan Murnick , et al. · 2023

Gamma-aminobutyric acid (GABA) and glutamatergic system perturbations following premature birth may explain neurodevelopmental deficits in the absence of structural brain injury. Using GABA-edited spectroscopy (MEscher-GArwood Point Resolv…

In infants with congenital heart disease autonomic dysfunction is associated with pre-operative brain injury Open

Sarah D. Schlatterer, Rathinaswamy B. Govindan, Jonathan Murnick, Scott D. Barnett, Catherine Lopez , et al. · 2021

Longitudinal Trajectories of Regional Cerebral Blood Flow in Very Preterm Infants during Third Trimester Ex Utero Development Assessed with MRI Open

Zungho Zun, Kushal Kapse, Marni Jacobs, Sudeepta K. Basu, Mariam Said , et al. · 2021

Background The third trimester of gestation is a crucial phase of rapid brain development, but little has been reported on the trajectories of cerebral blood flow (CBF) in preterm infants in this period. Purpose To quantify regional CBF in…

The utility of the fronto-temporal horn ratio on cranial ultrasound in premature newborns: a ventriculomegaly marker Open

Rawad Obeid, Marni Jacobs, Taeun Chang, An N. Massaro, Eresha Bluth , et al. · 2021

Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicentre collaborative study Open

Camilla Lindan, Kshitij Mankad, Dipak Ram, Larry K. Kociolek, V. Michelle Silvera , et al. · 2020

DIPG-80. CLINICAL AND RADIOGRAPHIC RESPONSE TO ONC201 IN A PEDIATRIC PATIENT WITH A THALAMIC H3K27M AND BRAFV600E MUTANT DIFFUSE MIDLINE HIGH GRADE GLIOMA Open

Elizabeth S. Duke, Jonathan Murnick, Rohinton S. Tarapore, Joshua E. Allen, Lindsay Kilburn · 2020

Recent improved understanding of the molecular markers of high grade glioma has shifted the approach to these aggressive CNS tumors to increasingly use molecularly guided targeted therapies. Treatment of patients with BRAFV600E mutant high…

170. Acute Flaccid Myelitis: Patient Characteristics and Prospective Follow-up Study at Children’s National Hospital, 2013–2019 Open

Alexandra B. Yonts, Nada Harik, Alyssa Doslea, Jonathan Murnick, Jessica L. Carpenter , et al. · 2020

Background Acute Flaccid Myelitis (AFM), diagnosed almost exclusively in children, is characterized by sudden onset flaccid weakness in one or more extremities with distinct gray matter spinal cord lesions on magnetic resonance imaging (MR…

Age and Sex Influences Gamma-aminobutyric Acid Concentrations in the Developing Brain of Very Premature Infants Open

Sudeepta K. Basu, Subechhya Pradhan, Marni Jacobs, Mariam Said, Kushal Kapse , et al. · 2020

Gamma-aminobutyric acid (GABA) and glutamate are principal neurotransmitters essential for late gestational brain development and may play an important role in prematurity-related brain injury. In vivo investigation of GABA in the preterm …

Functional brain connectivity in ex utero premature infants compared to in utero fetuses Open

Josepheen De Asis‐Cruz, Kushal Kapse, Sudeepta K. Basu, Mariam Said, Dustin Scheinost , et al. · 2020

Brain structural changes in premature infants appear before term age. Functional differences between premature infants and healthy fetuses during this period have yet to be explored. Here, we examined brain connectivity using resting state…

Presence of a collateral venous sinus drainage pathway predicts outcome of anticoagulation therapy following cerebral sinus venous thrombosis (CSVT) in children Open

Marcin Czarniecki, Jonathan Murnick · 2020

Differentiating posterior fossa venous sinus thrombosis from extrinsic compression by epidural hematoma in children Open

Marcin Czarniecki, Jonathan Murnick · 2020

Early Lipid Intake Improves Cerebellar Growth in Very Low‐Birth‐Weight Preterm Infants Open

Katherine M. Ottolini, Nickie Andescavage, Kushal Kapse, Marni Jacobs, Jonathan Murnick , et al. · 2020

Background Despite recent advances in nutrition practice in the neonatal intensive care unit, infants remain at high risk for growth restriction following preterm birth. Additionally, optimal values for macronutrient administration, especi…

Cerebral venous volume changes and pressure autoregulation in critically ill infants Open

Vedavalli Govindan, Rathinaswamy B. Govindan, An N. Massaro, Tareq Al‐Shargabi, Nickie Andescavage , et al. · 2020

Altered local cerebellar and brainstem development in preterm infants Open

Yao Wu, Catherine J. Stoodley, Marie Brossard‐Racine, Kushal Kapse, Gilbert Vézina , et al. · 2020

Altered Functional Brain Network Integration, Segregation, and Modularity in Infants Born Very Preterm at Term-Equivalent Age Open

Marine Bouyssi-Kobar, Josepheen De Asis‐Cruz, Jonathan Murnick, Taeun Chang, Catherine Limperopoulos · 2019

Placental Pathology and Neuroimaging Correlates in Neonates with Congenital Heart Disease Open

Sarah D. Schlatterer, Jonathan Murnick, Marni Jacobs, Linda R. White, Mary T. Donofrio , et al. · 2019

Third Trimester Cerebellar Metabolite Concentrations are Decreased in Very Premature Infants with Structural Brain Injury Open

Sudeepta K. Basu, Subechhya Pradhan, Kushal Kapse, Robert McCarter, Jonathan Murnick , et al. · 2019

Early extra-uterine exposure alters regional cerebellar growth in infants born preterm Open

Marie Brossard‐Racine, Robert McCarter, Jonathan Murnick, Laura Tinkleman, Gilbert Vézina , et al. · 2018

RONC-05. NEUROLOGIC COMPROMISE AND OUTCOME AFTER PROTON BEAM THERAPY (PBT) FOR POSTERIOR FOSSA TUMORS (PFTs) OF CHILDHOOD Open

Aimee Sato, Jonathan Murnick, Matthew Ladra, Elizabeth Wells, Lindsay Kilburn , et al. · 2018

The outcomes and neurologic status of patients after PBT have been incompletely characterized, although radiographic changes have been described. The neurologic status of 29 consecutive children treated with PBT (a median of 44 months of a…

Author Correction: Altered Cerebellar Biochemical Profiles in Infants Born Prematurely Open

Marie Brossard‐Racine, Jonathan Murnick, Marine Bouyssi-Kobar, Janie Coulombe, Taeun Chang , et al. · 2018

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