Jonathan Clayden
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View article: Redox-powered autonomous directional C–C bond rotation under enzyme control
Redox-powered autonomous directional C–C bond rotation under enzyme control Open
Living biological systems rely on the continuous operation of chemical reaction networks. These networks sustain out-of-equilibrium regimes in which chemical energy is continually converted into controlled mechanical work and motion 1–3 . …
View article: <i>De novo</i> designed 3-helix bundle peptides and proteins with controlled topology and stability
<i>De novo</i> designed 3-helix bundle peptides and proteins with controlled topology and stability Open
Computational protein design is advancing rapidly. However, approaches and methods are needed to increase success rates and to elaborate designs. Here we describe the combination of rational and computational design to deliver three-helix …
View article: The use of intraoperative tractography in brain tumor and epilepsy surgery: a systematic review and meta-analysis
The use of intraoperative tractography in brain tumor and epilepsy surgery: a systematic review and meta-analysis Open
Introduction Tractography is the only available technique for visualizing whitematter pathways within the living brain. Avoiding these pathways during surgical interventions for brain tumors and epilepsy is key to reducing postoperative ne…
View article: Asymmetric Intramolecular α‐Arylation of Polar Amino Acids Bearing β‐Leaving Groups
Asymmetric Intramolecular α‐Arylation of Polar Amino Acids Bearing β‐Leaving Groups Open
The α‐arylation of amino acids may be achieved by intramolecular nucleophilic aromatic substitution (S N Ar) reactions of amino‐acid derived enolates, but for amino acids bearing β‐leaving groups, such reactions are complicated by competin…
View article: Asymmetric Intramolecular α‐Arylation of Polar Amino Acids Bearing β‐Leaving Groups
Asymmetric Intramolecular α‐Arylation of Polar Amino Acids Bearing β‐Leaving Groups Open
The α‐arylation of amino acids may be achieved by intramolecular nucleophilic aromatic substitution (S N Ar) reactions of amino‐acid derived enolates, but for amino acids bearing β‐leaving groups, such reactions are complicated by competin…
View article: Using Color to Control Conformation in a Chemical System Containing Multiple Tricyanofuran Photoacids
Using Color to Control Conformation in a Chemical System Containing Multiple Tricyanofuran Photoacids Open
Color vision relies on selective, reversible isomerization by visible light of a mixture of retinyl chromophores in photoreceptor cells. Synthetic molecular mimics of this wavelength‐dependent induction of function are rare, despite the at…
View article: Using Color to Control Conformation in a Chemical System Containing Multiple Tricyanofuran Photoacids
Using Color to Control Conformation in a Chemical System Containing Multiple Tricyanofuran Photoacids Open
Color vision relies on selective, reversible isomerization by visible light of a mixture of retinyl chromophores in photoreceptor cells. Synthetic molecular mimics of this wavelength‐dependent induction of function are rare, despite the at…
View article: <i>De novo</i> designed 3-helix bundle peptides and proteins with controlled topology and stability
<i>De novo</i> designed 3-helix bundle peptides and proteins with controlled topology and stability Open
Rational design yields topologically defined three-helix peptide assemblies and single-chain proteins. X-ray structures confirm atomic accuracy, with buried polar residues controlling structure and modulating stability.
View article: Author Correction: Switching imidazole reactivity by dynamic control of tautomer state in an allosteric foldamer
Author Correction: Switching imidazole reactivity by dynamic control of tautomer state in an allosteric foldamer Open
View article: Intramolecular Nucleophilic Vinylic Substitution (S<sub>N</sub>V) by Carbon Nucleophiles: Conformationally Directed Formation of Dienes from <i>N</i>,<i>N’</i>‐Diallyl Ureas
Intramolecular Nucleophilic Vinylic Substitution (S<sub>N</sub>V) by Carbon Nucleophiles: Conformationally Directed Formation of Dienes from <i>N</i>,<i>N’</i>‐Diallyl Ureas Open
Nucleophilic vinylic substitution (S N V) by carbon nucleophiles allows the formation of vinylic C−C bonds without transition metal catalysts. In this paper, we show that tethering two alkenes together through a urea linkage can lead to th…
View article: Selective Defluorination of Trifluoromethyl Substituents by Conformationally Induced Remote Substitution
Selective Defluorination of Trifluoromethyl Substituents by Conformationally Induced Remote Substitution Open
The selective reduction of an aromatic trifluoromethyl substituent to a difluoromethyl substituent may be achieved by base‐promoted elimination to form a difluoro‐ p ‐quinomethide which is trapped by an intramolecular nucleophile. High yie…
View article: Selective Defluorination of Trifluoromethyl Substituents by Conformationally Induced Remote Substitution
Selective Defluorination of Trifluoromethyl Substituents by Conformationally Induced Remote Substitution Open
The selective reduction of an aromatic trifluoromethyl substituent to a difluoromethyl substituent may be achieved by base‐promoted elimination to form a difluoro‐ p ‐quinomethide which is trapped by an intramolecular nucleophile. High yie…
View article: Redox-powered autonomous unidirectional rotation about a C–C bond under enzymatic control
Redox-powered autonomous unidirectional rotation about a C–C bond under enzymatic control Open
Living biological systems rely on the continuous operation of chemical reaction networks. These networks sustain out-of-equilibrium regimes in which chemical energy is continually converted into controlled mechanical work and motion. Out-o…
View article: Benzo‐fused Nitrogen Heterocycles by Asymmetric Ring Expansion and Stereochemically Retentive Re‐contraction of Cyclic Ureas
Benzo‐fused Nitrogen Heterocycles by Asymmetric Ring Expansion and Stereochemically Retentive Re‐contraction of Cyclic Ureas Open
Benzo‐fused nitrogen heterocycles are common features of bioactive molecules, and the enantioselective synthesis of their substituted analogues is an important goal. In this paper we demonstrate a practical and mechanistically intriguing a…
View article: Benzo‐fused Nitrogen Heterocycles by Asymmetric Ring Expansion and Stereochemically Retentive Re‐contraction of Cyclic Ureas
Benzo‐fused Nitrogen Heterocycles by Asymmetric Ring Expansion and Stereochemically Retentive Re‐contraction of Cyclic Ureas Open
Benzo‐fused nitrogen heterocycles are common features of bioactive molecules, and the enantioselective synthesis of their substituted analogues is an important goal. In this paper we demonstrate a practical and mechanistically intriguing a…
View article: CCDC 2262692: Experimental Crystal Structure Determination
CCDC 2262692: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2262697: Experimental Crystal Structure Determination
CCDC 2262697: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2262696: Experimental Crystal Structure Determination
CCDC 2262696: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2262694: Experimental Crystal Structure Determination
CCDC 2262694: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2262693: Experimental Crystal Structure Determination
CCDC 2262693: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2262695: Experimental Crystal Structure Determination
CCDC 2262695: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Dynamic and Persistent Cyclochirality in Hydrogen-Bonded Derivatives of Medium-Ring Triamines
Dynamic and Persistent Cyclochirality in Hydrogen-Bonded Derivatives of Medium-Ring Triamines Open
Cyclic triureas derived from 1,4,7-triazacyclononane (TACN) were synthesized; X-ray crystallography showed a chiral bowl-like conformation with each urea hydrogen-bonded to its neighbor with uniform directionality, forming a "cyclochiral" …
View article: Anion‐Dependent Hydrogen‐Bond Polarity Switching in Ethylene‐bridged Urea Oligomers
Anion‐Dependent Hydrogen‐Bond Polarity Switching in Ethylene‐bridged Urea Oligomers Open
The reversible coordination of anions to an N , N’ ‐disubstituted 3,5‐bis(trifluoromethyl)phenylurea located at a terminus of a linear chain of ethylene‐bridged hydrogen‐bonded ureas triggers a cascade of conformational changes. A series o…
View article: Electrochemical synthesis of biaryls by reductive extrusion from N,N’-diarylureas
Electrochemical synthesis of biaryls by reductive extrusion from N,N’-diarylureas Open
The synthesis of biaryl compounds by the transition-metal free coupling of arenes is an important contemporary challenge, aiming to avoid the toxicity and cost profiles associated with the metal catalysts commonly used in the synthesis of …
View article: CCDC 2264158: Experimental Crystal Structure Determination
CCDC 2264158: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Switching imidazole reactivity by dynamic control of tautomer state in an allosteric foldamer
Switching imidazole reactivity by dynamic control of tautomer state in an allosteric foldamer Open
View article: Graphical Abstract: Angew. Chem. Int. Ed. 14/2023
Graphical Abstract: Angew. Chem. Int. Ed. 14/2023 Open
Angewandte Chemie International Edition is aj ournalo ft he Gesellschaft Deutscher Chemiker (GDCh), the largest chemistryrelated scientific society in continental Europe.Information on the various activities and services of the GDCh, for e…
View article: Graphisches Inhaltsverzeichnis: Angew. Chem. 14/2023
Graphisches Inhaltsverzeichnis: Angew. Chem. 14/2023 Open
…of[3]catenane was induced by fitting the puzzle pieces.Intheir Research Article (202217002), JunT erao et al. report amethod for ligand-controlled structural switching of [3]catenane,w hich was realized by the complexation of metal ions o…
View article: CCDC 2243116: Experimental Crystal Structure Determination
CCDC 2243116: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Enantioselective Intramolecular α‐Arylation of Benzylamine Derivatives: Synthesis of a Precursor to Levocetirizine
Enantioselective Intramolecular α‐Arylation of Benzylamine Derivatives: Synthesis of a Precursor to Levocetirizine Open
A practical, transition metal‐free method allows the enantioselective synthesis of α,α‐diarylmethylamines by asymmetric α‐arylation of benzylamines. Enantioselective lithiation of N ′‐aryl‐ N ‐benzyl‐ N ‐isopropyl ureas using a chiral lith…