Jonathan Plassais
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View article: Results from EDIFICE : A French pilot study on COVID-19 and the gut microbiome in a hospital environment
Results from EDIFICE : A French pilot study on COVID-19 and the gut microbiome in a hospital environment Open
BACKGROUND & AIMS Early reports suggest that both fecal shedding and dysbiosis of the gut microbiome are associated to disease severity in COVID-19 patients. We investigated the gut microbiome as well as the prevalence of SARS-CoV-2 in sto…
View article: Blockage of bacterial FimH prevents mucosal inflammation associated with Crohn’s disease
Blockage of bacterial FimH prevents mucosal inflammation associated with Crohn’s disease Open
Background An Escherichia coli ( E. coli ) pathotype with invasive properties, first reported by Darfeuille-Michaud and termed adherent-invasive E. coli (AIEC), was shown to be prevalent in up to half the individuals with Crohn’s Disease (…
View article: Gut microbiome alpha-diversity is not a marker of Parkinson’s disease and multiple sclerosis
Gut microbiome alpha-diversity is not a marker of Parkinson’s disease and multiple sclerosis Open
The gut–brain axis may play a central role in the pathogenesis of neurological disorders. Dozens of case–control studies have been carried out to identify bacterial markers by the use of targeted metagenomics. Alterations of several taxono…
View article: Incorporating Phylogenetic Information in Microbiome Differential Abundance Studies Has No Effect on Detection Power and FDR Control
Incorporating Phylogenetic Information in Microbiome Differential Abundance Studies Has No Effect on Detection Power and FDR Control Open
We consider the problem of incorporating evolutionary information (e.g., taxonomic or phylogenic trees) in the context of metagenomics differential analysis. Recent results published in the literature propose different ways to leverage the…
View article: Impact of laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy on gut microbiota: a metagenomic comparative analysis
Impact of laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy on gut microbiota: a metagenomic comparative analysis Open
Microbiota changes after bariatric surgery depend on the nature of the intervention. LRYGB induces greater taxonomic and functional changes in gut microbiota than SG. Possible long-term health consequences of these alterations remain to be…
View article: Incorporating phylogenetic information in microbiome abundance studies has no effect on detection power and FDR control
Incorporating phylogenetic information in microbiome abundance studies has no effect on detection power and FDR control Open
We consider the problem of incorporating evolutionary information (e.g. taxonomic or phylogenic trees) in the context of metagenomics differential analysis. Recent results published in the literature propose different ways to leverage the …
View article: Tu1854 – Association Between Qpcr Assays Targeting Fims/Fimh and Aggregation to Eb8018 : Results of the Mobidic Study (Molecular Biomarkers and Adherent and Invasive Escherichia COLI (AIEC) Detection Study in Crohn's Disease Patients)
Tu1854 – Association Between Qpcr Assays Targeting Fims/Fimh and Aggregation to Eb8018 : Results of the Mobidic Study (Molecular Biomarkers and Adherent and Invasive Escherichia COLI (AIEC) Detection Study in Crohn's Disease Patients) Open
View article: Laparoscopic Roux-en-Y gastric bypass profoundly changes gut microbiota compared to laparoscopic sleeve gastrectomy: a metagenomic comparative analysis
Laparoscopic Roux-en-Y gastric bypass profoundly changes gut microbiota compared to laparoscopic sleeve gastrectomy: a metagenomic comparative analysis Open
Background Bariatric surgery is an effective therapeutic procedure for morbidly obese patients as it induces sustained weight loss. The two most common interventions are Laparoscopic Sleeve Gastrectomy (LSG) and Laparoscopic Roux-en-Y Gast…
View article: Transcriptome modulation by hydrocortisone in severe burn shock: ancillary analysis of a prospective randomized trial
Transcriptome modulation by hydrocortisone in severe burn shock: ancillary analysis of a prospective randomized trial Open
ClinicalTrials.gov, NCT00149123 . Registered on 6 September 2005.
View article: Gut Microbial Diversity Is Reduced in Smokers with Crohnʼs Disease
Gut Microbial Diversity Is Reduced in Smokers with Crohnʼs Disease Open
Gut microbial diversity is reduced in smokers with CD compared with nonsmokers with CD. The microbial profile differs between these groups at the genus level. Future studies should evaluate whether intestinal microbes mediate the adverse e…
View article: Low-dose hydrocortisone reduces norepinephrine duration in severe burn patients: a randomized clinical trial
Low-dose hydrocortisone reduces norepinephrine duration in severe burn patients: a randomized clinical trial Open