Explanipedia

Missense Variants in the Second Transmembrane Domain of <span>TMEM17</span> Disrupt Its Stability and Function and Lead to a Wide Phenotypic Spectrum of Ciliopathies Open

Lucile Boutaud, Chunmei Li, Candice Moncler, Laure Verlin, Meriem Garfa‐Traoré , et al. · 2025

Ciliopathies are rare genetic disorders characterized by significant genetic and phenotypic variability. Over 140 proteins localized to primary cilia, which are sensory organelles essential for vertebrate development, are implicated. TMEM1…

3D ultrasound localization microscopy of the nonhuman primate brain Open

Paul Xing, Vincent Perrot, Adan‐Ulises Dominguez‐Vargas, Jonathan Porée, Stephan Quessy , et al. · 2024

This work was supported by the New Frontier in Research Fund (NFRFE-2022-00590), by the Canada Foundation for Innovation under grant 38095, by the Natural Sciences and Engineering Research Council of Canada (NSERC) under discovery grant RG…

Functional Assessment of Cerebral Capillaries using Single Capillary Reporters in Ultrasound Localization Microscopy Open

Stephen A. Lee, Alexis Leconte, Alice Wu, Joshua Kinugasa, Jonathan Porée , et al. · 2024

The brain's microvascular cerebral capillary network plays a vital role in maintaining neuronal health, yet capillary dynamics are still not well understood due to limitations in existing imaging techniques. Here, we present Single Capilla…

Boosting Cardiac Color Doppler Frame Rates With Deep Learning Open

Julia Puig, Denis Friboulet, Hang Jung Ling, François Varray, Michael Mougharbel , et al. · 2024

Color Doppler echocardiography enables visualization of blood flow within the heart. However, the limited frame rate impedes the quantitative assessment of blood velocity throughout the cardiac cycle, thereby compromising a comprehensive a…

3D transcranial Dynamic Ultrasound Localization Microscopy in the mouse brain using a Row-Column Array Open

Alice Wu, Jonathan Porée, Gerardo Ramos-Palacios, Chloé Bourquin, Nin Ghigo , et al. · 2024

The role of brain hemodynamics in neurodegenerative diseases cannot be fully assessed using existing imaging technologies. Recently, 2D Dynamic Ultrasound Localization Microscopy (DULM) has allowed for the quantitative mapping of the pulsa…

Pruning Sparse Tensor Neural Networks Enables Deep Learning for 3D Ultrasound Localization Microscopy Open

Brice Rauby, Paul Xing, Jonathan Porée, Maxime Gasse, Jean Provost · 2024

Ultrasound Localization Microscopy (ULM) is a non-invasive technique that allows for the imaging of micro-vessels in vivo, at depth and with a resolution on the order of ten microns. ULM is based on the sub-resolution localization of indiv…

Quantitative pulsatility measurements using 3D dynamic ultrasound localization microscopy Open

Chloé Bourquin, Jonathan Porée, Brice Rauby, Vincent Perrot, Nin Ghigo , et al. · 2024

A rise in blood flow velocity variations (i.e. pulsatility) in the brain, caused by the stiffening of upstream arteries, is associated with cognitive impairment and neurodegenerative diseases. The study of this phenomenon requires brain-wi…

Equivalent-time-active-cavitation-imaging enables vascular-resolution blood-brain-barrier-opening-therapy planning Open

Samuel Desmarais, Gerardo Ramos-Palacios, Jonathan Porée, Stephen A. Lee, Alexis Leconte , et al. · 2023

Objective . Linking cavitation and anatomy was found to be important for predictable outcomes in focused-ultrasound blood-brain-barrier-opening and requires high resolution cavitation mapping. However, cavitation mapping techniques for pla…

A unified framework combining coherent compounding, harmonic imaging and angular coherence for simultaneous high-quality B-mode and tissue Doppler in ultrafast echocardiography Open

Michael Mougharbel, Jonathan Porée, Stephen A. Lee, Paul Xing, Alice Wu , et al. · 2023

Various methods have been proposed to enhance image quality in ultrafast ultrasound. Coherent compounding can improve image quality using multiple steered diverging transmits when motion occurring between transmits is corrected for. Harmon…

Dynamic Imaging using any Ultrasound Localization Microscopy Dataset Open

Nin Ghigo, Gerardo Ramos-Palacios, Chloé Bourquin, Paul Xing, Alice Wu , et al. · 2023

Ultrasound Localization Microscopy (ULM) relies on the injection of microbubbles (MBs) to obtain highly resolved density maps of blood circulation in vivo, with a resolution that can reach 10 μm ~ λ/10 in the rodent brain. Static mean velo…

Ultrafast Cardiac Imaging Using Deep Learning for Speckle-Tracking Echocardiography Open

Jingfeng Lu, Fabien Millioz, François Varray, Jonathan Porée, Jean Provost , et al. · 2023

High-quality ultrafast ultrasound imaging is based on coherent compounding from multiple transmissions of plane waves (PW) or diverging waves (DW). However, compounding results in reduced frame rate, as well as destructive interferences fr…

Ergodic encoding for single-element ultrasound imaging in vivo Open

Olivier Caron-Grenier, Jonathan Porée, Vincent Perrot, Gerardo Ramos-Palacio, Abbas F. Sadikot , et al. · 2023

Conventional ultrasound imaging relies on the computation of geometric time delay from multiple sensors to detect the position of a scatterer. In this paper, we present Ergodic Relay Ultrasound Imaging (ERUI), a method that utilizes an erg…

Equivalent-Time-Active-Cavitation-Imaging Enables Vascular-Resolution Blood-Brain-Barrier-Opening-Therapy Planning Open

Samuel Desmarais, Gerardo Ramos-Palacios, Jonathan Porée, Stephen A. Lee, Alexis Leconte , et al. · 2023

Linking cavitation and anatomy was found to be important for predictable outcomes in Focused-Ultrasound Blood-Brain-Barrier-Opening and requires high resolution cavitation mapping. However, cavitation mapping techniques for planning and mo…

A Tracking prior to Localization workflow for Ultrasound Localization Microscopy Open

Alexis Leconte, Jonathan Porée, Brice Rauby, Alice Wu, Nin Ghigo , et al. · 2023

Ultrasound Localization Microscopy (ULM) has proven effective in resolving microvascular structures and local mean velocities at sub-diffraction-limited scales, offering high-resolution imaging capabilities. Dynamic ULM (DULM) enables the …

Ultrafast Cardiac Imaging Using Deep Learning For Speckle-Tracking Echocardiography Open

Jingfeng Lu, Fabien Millioz, François Varray, Jonathan Porée, Jean Provost , et al. · 2023

High-quality ultrafast ultrasound imaging is based on coherent compounding from multiple transmissions of plane waves (PW) or diverging waves (DW). However, compounding results in reduced frame rate, as well as destructive interferences fr…

Quantitative pulsatility measurements using 3D Dynamic Ultrasound Localization Microscopy Open

Chloé Bourquin, Jonathan Porée, Brice Rauby, Vincent Perrot, Nin Ghigo , et al. · 2023

A rise in blood flow velocity variations (i.e., pulsatility) in the brain, caused by the stiffening of upstream arteries, is associated with cognitive impairment and neurodegenerative diseases. The study of this phenomenon requires brain-w…

An Anatomically Realistic Simulation Framework for 3D Ultrasound Localization Microscopy Open

Hatim Belgharbi, Jonathan Porée, Rafat Damseh, Vincent Perrot, Léo Milecki , et al. · 2023

The resolution of 3D Ultrasound Localization Microscopy (ULM) is determined by acquisition parameters such as frequency and transducer geometry but also by microbubble (MB) concentration, which is linked to the total acquisition time neede…

Phase Aberration Correction for in vivo Ultrasound Localization Microscopy Using a Spatiotemporal Complex-Valued Neural Network Open

Paul Xing, Jonathan Porée, Brice Rauby, Antoine Malescot, Éric Martineau , et al. · 2022

Ultrasound Localization Microscopy (ULM) can map microvessels at a resolution of a few micrometers (μm). Transcranial ULM remains challenging in presence of aberrations caused by the skull, which lead to localization errors. Herein, we pro…

An Anatomically and Hemodynamically Realistic Simulation Framework for 3D Ultrasound Localization Microscopy Open

Hatim Belgharbi, Jonathan Porée, Rafat Damseh, Vincent Perrot, Léo Milecki , et al. · 2021

The resolution of 3D Ultrasound Localization Microscopy (ULM) is determined by acquisition parameters such as frequency and transducer geometry but also by microbubble (MB) concentration, which is also linked to the total acquisition time …

Equivalent time active cavitation imaging Open

Simon Blais, Jonathan Porée, Gerardo Ramos-Palacios, Samuel Desmarais, Vincent Perrot , et al. · 2021

Rationale . Despite the development of a large number of neurologically active drugs, brain diseases are difficult to treat due to the inability of many drugs to penetrate the blood-brain barrier. High-intensity focused ultrasound (HIFU) b…

Sparse channel sampling for ultrasound localization microscopy (SPARSE-ULM) Open

Erwan Hardy, Jonathan Porée, Hatim Belgharbi, Chloé Bourquin, Frédéric Lesage , et al. · 2021

Ultrasound localization microscopy (ULM) has recently enabled the mapping of the cerebral vasculature in vivo with a resolution ten times smaller than the wavelength used, down to ten microns. However, with frame rates up to 20000 frames p…

A Deep Learning Framework for Spatiotemporal Ultrasound Localization Microscopy Open

Léo Milecki, Jonathan Porée, Hatim Belgharbi, Chloé Bourquin, Rafat Damseh , et al. · 2021

Ultrasound Localization Microscopy (ULM) can resolve the microvascular bed down to a few micrometers. To achieve such performance, microbubble contrast agents must perfuse the entire microvascular network. Microbubbles are then located ind…

Ultrafast Ultrasound Imaging for Super-Resolution Preclinical Cardiac PET Open

Mailyn Pérez-Liva, Thulaciga Yoganathan, Joaquín L. Herraiz, Jonathan Porée, Mickaël Tanter , et al. · 2020

Purpose Physiological motion and partial volume effect (PVE) significantly degrade the quality of cardiac positron emission tomography (PET) images in the fast-beating hearts of rodents. Several Super-resolution (SR) techniques using a pri…

Innovative Multiparametric Characterization of Carotid Plaque Vulnerability by Ultrasound Open

Guillaume Goudot, Lina Khider, Olivier Pedreira, Jonathan Porée, Pierre Julia , et al. · 2020

Ultrafast ultrasound imaging is an innovative, easily accessible technique that provides imaging modalities on top of the conventional B-mode. Ultrafast ultrasound biomarkers such as plaque stiffness heterogeneity, WSS and intraplaque micr…

Carotid Stiffness Assessment With Ultrafast Ultrasound Imaging in Case of Bicuspid Aortic Valve Open

Guillaume Goudot, Tristan Mirault, Lina Khider, Olivier Pedreira, Charles Cheng , et al. · 2019

Our results clearly show that the carotid stiffness and flow parameters are not altered in case of BAV compared with controls.

Accuracy of speckle tracking in the context of stress echocardiography in short axis view: An in vitro validation study Open

Amir Hodžić, Boris Chayer, Diya Wang, Jonathan Porée, Guy Cloutier , et al. · 2018

Speckle tracking demonstrated a good correlation with sonomicrometry for the assessment of radial strain independently of the heart rate and strain magnitude in a physiological range of values. Though speckle tracking seems to be a reliabl…

High-Frame-Rate Speckle-Tracking Echocardiography Open

Philippe Joos, Jonathan Porée, Hervé Liebgott, Didier Vray, Mathilde Baudet , et al. · 2018

Conventional echocardiography is the leading modality for noninvasive cardiac imaging. It has been recently illustrated that high-frame-rate echocardiography using diverging waves could improve cardiac assessment. The spatial resolution an…

Spatiotemporal matrix image formation for programmable ultrasound scanners Open

Béatrice Berthon, Pierre Morichau‐Beauchant, Jonathan Porée, Anikitos Garofalakis, Bertrand Tavitian , et al. · 2018

As programmable ultrasound scanners become more common in research laboratories, it is increasingly important to develop robust software-based image formation algorithms that can be obtained in a straightforward fashion for different types…

Évaluation de la biomécanique cardiovasculaire par élastographie ultrasonore non-invasive Open

Jonathan Porée · 2016

L’élastographie est une technique d’imagerie qui vise à cartographier in vivo les propriétés mécaniques des tissus biologiques dans le but de fournir des informations diagnostiques additionnelles. Depuis son introduction en imagerie ultras…

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