Jonathan R. Epp
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View article: Activity of CaMKII-expressing neurons in medial prefrontal cortex of male and female Long-Evans rats is necessary for encoding odor information and novelty recognition in an odor-based incidental memory test
Activity of CaMKII-expressing neurons in medial prefrontal cortex of male and female Long-Evans rats is necessary for encoding odor information and novelty recognition in an odor-based incidental memory test Open
Incidental memories encoded through spontaneous interaction with stimuli in an environment contribute to higher cognitive functions. The spontaneous Identical (IST) and the Different Stimuli Tests (DST), with objects and odors, allow for i…
View article: Genetic variants disrupting activity-dependent CELF2 shuttling cause neuronal hyperexcitability, learning deficits, and seizures
Genetic variants disrupting activity-dependent CELF2 shuttling cause neuronal hyperexcitability, learning deficits, and seizures Open
De novo heterozygous variants in the CELF2 gene have recently been associated with a rare neurodevelopmental disorder. However, the mechanisms linking specific variants to distinct clinical phenotypes remain poorly understood. Here, we rep…
View article: An Open-Source and Highly Adaptable Rodent Limited Bedding and Nesting Apparatus for Chronic Early Life Stress
An Open-Source and Highly Adaptable Rodent Limited Bedding and Nesting Apparatus for Chronic Early Life Stress Open
Early life stress (ELS) increases susceptibility to cognitive and socioemotional dysfunction by disrupting the neurobiological systems that regulate these behaviors. Animal models provide a valuable tool for investigating the underlying me…
View article: Inhibitory Circuit Compensations in Female and Male Mice: Increased Synaptic Output Offsets Reduced Parvalbumin Interneuron Density
Inhibitory Circuit Compensations in Female and Male Mice: Increased Synaptic Output Offsets Reduced Parvalbumin Interneuron Density Open
Summary Parvalbumin inhibitory interneurons (PV-INs) are critical regulators of excitatory/inhibitory balance in the cortex, and their dysfunction has been observed in various neurological disorders. Despite increasing recognition of sex d…
View article: Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer’s disease
Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer’s disease Open
Alzheimer’s disease is a debilitating neurodegenerative disorder with no cure and few treatment options. In early stages of Alzheimer’s disease, impaired metabolism and functional connectivity of the retrosplenial cortex strongly predict f…
View article: SSRIs reduce plasma tau and restore dorsal raphe metabolism in Alzheimer's disease
SSRIs reduce plasma tau and restore dorsal raphe metabolism in Alzheimer's disease Open
INTRODUCTION Tau pathology impacts neurodegeneration and cognitive decline in Alzheimer's disease (AD), with the dorsal raphe nucleus (DRN) being among the brain regions showing the earliest tau pathology. As a serotonergic hub, DRN activi…
View article: Cognitive enrichment preserves retrosplenial parvalbumin density and cognitive function in female 5xFAD mice
Cognitive enrichment preserves retrosplenial parvalbumin density and cognitive function in female 5xFAD mice Open
BACKGROUND The rate of cognitive decline in Alzheimer’s disease (AD) varies considerably from person to person. Numerous epidemiological studies point to the protective effects of cognitive, social, and physical enrichment as potential med…
View article: Retrosplenial hypometabolism precedes the conversion from mild cognitive impairment to Alzheimer's disease
Retrosplenial hypometabolism precedes the conversion from mild cognitive impairment to Alzheimer's disease Open
INTRODUCTION Not all individuals who experience mild cognitive impairment (MCI) transition through progressive stages of cognitive decline at the same rate, if at all. Previous observational studies have identified the retrosplenial cortex…
View article: Running-induced neurogenesis reduces CA1 perineuronal net density without substantial temporal delay
Running-induced neurogenesis reduces CA1 perineuronal net density without substantial temporal delay Open
Aerobic exercise has many effects on brain function, particularly at the hippocampus. Exercise has been shown to increase the rate of adult neurogenesis within the dentate gyrus and decrease the density of perineuronal nets in area CA1. Th…
View article: Long-Term Impact of Early-Life Stress on Serotonin Connectivity
Long-Term Impact of Early-Life Stress on Serotonin Connectivity Open
These findings suggest a significant disruption in 5-HT-modulated brain connectivity in response to ELS, with implications for sex-dependent vulnerability. The anxiolytic effect of the raphe-medial OFC circuit stimulation has potential imp…
View article: PAW, a cost-effective and open-source alternative to commercial rodent running wheels
PAW, a cost-effective and open-source alternative to commercial rodent running wheels Open
Voluntary wheel running is a common measure of general activity in many rodent models across neuroscience and physiology. However, current commercial wheel monitoring systems can be cost-prohibitive to many investigators, with many of thes…
View article: Protocol for the integration of fiber photometry and social behavior in rodent models
Protocol for the integration of fiber photometry and social behavior in rodent models Open
Fiber photometry offers insight into cell-type-specific activity underlying social interactions. We provide a protocol for the integration of fiber photometry recordings into the analysis of social behavior in rodent models. This includes …
View article: Neurogenesis-mediated circuit remodeling reduces engram reinstatement and promotes forgetting
Neurogenesis-mediated circuit remodeling reduces engram reinstatement and promotes forgetting Open
Post-training increases in hippocampal neurogenesis are associated with forgetting of hippocampus-dependent memories in adult mice. This form of forgetting might be due to increased numbers of new neurons, remodeling of hippocampal circuit…
View article: Repeated episodes of postictal hypoxia are a mechanism for interictal cognitive impairments
Repeated episodes of postictal hypoxia are a mechanism for interictal cognitive impairments Open
View article: Long-term impact of early life stress on serotonin connectivity
Long-term impact of early life stress on serotonin connectivity Open
Chronic childhood stress is a prominent risk factor for developing mood disorders, yet mechanisms underlying this association remain unclear. Serotonin (5-HT) plays a crucial role in neurodevelopment and vulnerability to mood disorders. Ma…
View article: Hypocretin/orexin neurons encode social discrimination and exhibit a sex-dependent necessity for social interaction
Hypocretin/orexin neurons encode social discrimination and exhibit a sex-dependent necessity for social interaction Open
The hypothalamus plays a crucial role in the modulation of social behavior by encoding internal states. The hypothalamic hypocretin/orexin neurons, initially identified as regulators of sleep and appetite, are important for emotional and m…
View article: Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer’s disease
Impaired parvalbumin interneurons in the retrosplenial cortex as the cause of sex-dependent vulnerability in Alzheimer’s disease Open
Alzheimer’s disease is a debilitating neurodegenerative disorder with no cure and few treatment options. In early stages of Alzheimer’s disease, impaired metabolism, and functional connectivity of the retrosplenial cortex strongly predict …
View article: Classifying high-dimensional phenotypes with ensemble learning
Classifying high-dimensional phenotypes with ensemble learning Open
Classification is a fundamental task in biology used to assign members to a class. While linear discriminant functions have long been effective, advances in phenotypic data collection are yielding increasingly high-dimensional datasets wit…
View article: The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer’s Disease
The impact of loneliness and social isolation on the development of cognitive decline and Alzheimer’s Disease Open
Alzheimer's Disease (AD) is the leading cause of dementia, observed at a higher incidence in women compared with men. Treatments aimed at improving pathology in AD remain ineffective to stop disease progression. This makes the detection of…
View article: Connectivity changes following rTMS in rodent: evidence from multimodal imaging
Connectivity changes following rTMS in rodent: evidence from multimodal imaging Open
View article: Network Neuroscience Untethered: Brain-Wide Immediate Early Gene Expression for the Analysis of Functional Connectivity in Freely Behaving Animals
Network Neuroscience Untethered: Brain-Wide Immediate Early Gene Expression for the Analysis of Functional Connectivity in Freely Behaving Animals Open
Studying how spatially discrete neuroanatomical regions across the brain interact is critical to advancing our understanding of the brain. Traditional neuroimaging techniques have led to many important discoveries about the nature of these…
View article: Low intensity repetitive transcranial magnetic stimulation modulates brain-wide functional connectivity to promote anti-correlated c-Fos expression
Low intensity repetitive transcranial magnetic stimulation modulates brain-wide functional connectivity to promote anti-correlated c-Fos expression Open
Repetitive transcranial magnetic stimulation (rTMS) induces action potentials to induce plastic changes in the brain with increasing evidence for the therapeutic importance of brain-wide functional network effects of rTMS; however, the inf…
View article: Brain-wide neuronal activation and functional connectivity are modulated by prior exposure to repetitive learning episodes
Brain-wide neuronal activation and functional connectivity are modulated by prior exposure to repetitive learning episodes Open
Memory storage and retrieval are shaped by past experiences. Prior learning and memory episodes have numerous impacts on brain structure from micro to macroscale. Previous experience with specific forms of learning increases the efficiency…
View article: Network neuroscience untethered: brain-wide immediate early gene expression for the analysis of functional connectivity in freely behaving animals
Network neuroscience untethered: brain-wide immediate early gene expression for the analysis of functional connectivity in freely behaving animals Open
Studying how spatially discrete neuroanatomical regions across the brain interact is critical to advancing our understanding of the brain. Traditional neuroimaging techniques have led to many important discoveries about the nature of these…
View article: Hypocretin/orexin neurons encode social discrimination and exhibit a sex-dependent necessity for social interaction
Hypocretin/orexin neurons encode social discrimination and exhibit a sex-dependent necessity for social interaction Open
Summary Intraspecies social interactions are integral for survival and maintenance of society among all mammalian species. Yet, our understanding of the neural systems and mechanisms involved in the establishment of social connectedness ar…
View article: Low intensity repetitive transcranial magnetic stimulation modulates brain-wide functional connectivity to promote anti-correlated activity
Low intensity repetitive transcranial magnetic stimulation modulates brain-wide functional connectivity to promote anti-correlated activity Open
Background Repetitive transcranial magnetic stimulation (rTMS) induces action potentials to induce plastic changes in the brain with increasing evidence for the therapeutic importance of brain-wide functional network effects of rTMS; howev…
View article: Toxoplasma infection in male mice alters dopamine-sensitive behaviors and host gene expression patterns associated with neuropsychiatric disease
Toxoplasma infection in male mice alters dopamine-sensitive behaviors and host gene expression patterns associated with neuropsychiatric disease Open
During chronic infection, the single celled parasite, Toxoplasma gondii , can migrate to the brain where it has been associated with altered dopamine function and the capacity to modulate host behavior, increasing risk of neurocognitive di…
View article: New neurons in old brains: implications of age in the analysis of neurogenesis in post-mortem tissue
New neurons in old brains: implications of age in the analysis of neurogenesis in post-mortem tissue Open
Adult neurogenesis, the proliferation and integration of newly generated neurons, has been observed in the adult mammalian hippocampus of many species. Numerous studies have also found adult neurogenesis in the human hippocampus, but sever…
View article: Neurogenesis mediated plasticity is associated with reduced neuronal activity in CA1 during context fear memory retrieval
Neurogenesis mediated plasticity is associated with reduced neuronal activity in CA1 during context fear memory retrieval Open
Postnatal hippocampal neurogenesis has been demonstrated to affect learning and memory in numerous ways. Several studies have now demonstrated that increased neurogenesis can induce forgetting of memories acquired prior to the manipulation…
View article: FASTMAP: Open-Source Flexible Atlas Segmentation Tool for Multi-Area Processing of Biological Images
FASTMAP: Open-Source Flexible Atlas Segmentation Tool for Multi-Area Processing of Biological Images Open
To better understand complex systems, such as the brain, studying the interactions between multiple brain regions is imperative. Such experiments often require delineation of multiple brain regions on microscopic images based on preexistin…