Jonathan R. Seckl
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View article: Glucocorticoid metabolism: A scientific lifetime in and beyond psychoneuroendocrinology
Glucocorticoid metabolism: A scientific lifetime in and beyond psychoneuroendocrinology Open
View article: Ten Year Outcome of Anti‐Thyroid Drug Treatment for First Episode Graves' Thyrotoxicosis: The Predictive Importance of TRAb
Ten Year Outcome of Anti‐Thyroid Drug Treatment for First Episode Graves' Thyrotoxicosis: The Predictive Importance of TRAb Open
Objective To establish the risk and time course of recurrent thyrotoxicosis following withdrawal of anti‐thyroid drugs (ATD) and risk factors for recurrence. Design Single‐centre retrospective study. Methods Two hundred and ninety people w…
View article: Clinical Pharmacology and Approach to Dose Selection of Emestedastat, a Novel Tissue Cortisol Synthesis Inhibitor for the Treatment of Central Nervous System Disease
Clinical Pharmacology and Approach to Dose Selection of Emestedastat, a Novel Tissue Cortisol Synthesis Inhibitor for the Treatment of Central Nervous System Disease Open
This review demonstrates the value of central pharmacodynamics (PD), including positron emission tomography (PET) and computerized cognitive testing, to supplement pharmacokinetic (PK) and peripheral PD for determining the target dose rang…
View article: Development of Xanamem, an isoform 1 specific inhibitor of 11‐βHSD, as a procognitive and disease modifying treatment for mild/moderate Alzheimer’s disease. A pharmacodynamic and biomarker driven approach
Development of Xanamem, an isoform 1 specific inhibitor of 11‐βHSD, as a procognitive and disease modifying treatment for mild/moderate Alzheimer’s disease. A pharmacodynamic and biomarker driven approach Open
Background Selecting the optimal dose for clinical development is especially problematic for drugs directed at CNS‐specific targets. For drugs with a novel mechanism of action, these problems are often greater. We describe Xanamem’s clinic…
View article: 8312 Predictors of Mortality in Primary Hyperparathyroidism: Long-Term Follow Up
8312 Predictors of Mortality in Primary Hyperparathyroidism: Long-Term Follow Up Open
Disclosure: F.W. Gibb: None. J.R. Seckl: None. L. Reid: None. M.J. Lyall: None. Background: Primary hyperparathyroidism has been associated with an increased risk of death and cardiovascular disease in observational studies. We have previo…
View article: 11β‐Hydroxysteroid dehydrogenase and the brain: Not (yet) lost in translation
11β‐Hydroxysteroid dehydrogenase and the brain: Not (yet) lost in translation Open
11‐beta‐hydroxysteroid dehydrogenases (11β‐HSDs) catalyse the conversion of active 11‐hydroxy glucocorticoids (cortisol, corticosterone) and their inert 11‐keto forms (cortisone, 11‐dehydrocorticosterone). They were first reported in the b…
View article: New View on the Impact of the Low-Frequency Electromagnetic Field (50 Hz) on Stress Responses: Hormesis Effect
New View on the Impact of the Low-Frequency Electromagnetic Field (50 Hz) on Stress Responses: Hormesis Effect Open
Introduction: Low-frequency electromagnetic field (50 Hz) (EMF) can modify crucial neuronal processes. Existing data indicate that exposure to EMF may represent a mild stressor and contribute to disturbances of the hypothalamic-pituitary-a…
View article: 11β-Hydroxysteroid dehydrogenase 1 deficiency prevents PTSD-like memory in young adult mice
11β-Hydroxysteroid dehydrogenase 1 deficiency prevents PTSD-like memory in young adult mice Open
Post-traumatic stress disorder (PTSD) is characterized by the co-existence of a persistent strong memory of the traumatic experience and amnesia for the peritraumatic context. Most animal models, however, fail to account for the contextual…
View article: Supplementary Material for: New view on the impact of the low-frequency electromagnetic field (50 Hz) on stress responses – hormesis effect
Supplementary Material for: New view on the impact of the low-frequency electromagnetic field (50 Hz) on stress responses – hormesis effect Open
Introduction: Low-frequency electromagnetic field (50 Hz) (EMF) can modify crucial neuronal processes. Existing data indicate that exposure to EMF may represent a mild stressor and contribute to disturbances of hypothalamic-pituitary-adren…
View article: Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland
Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland Open
View article: Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments
Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments Open
STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on…
View article: Erratum. Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion. Diabetes 2015;64:733–745
Erratum. Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion. Diabetes 2015;64:733–745 Open
In Fig. 1 E of the above-cited article, there was a vertical flip in the HIF-2α image, which …
View article: Face coverings and respiratory tract droplet dispersion
Face coverings and respiratory tract droplet dispersion Open
Respiratory droplets are the primary transmission route for SARS-CoV-2, a principle which drives social distancing guidelines. Evidence suggests that virus transmission can be reduced by face coverings, but robust evidence for how mask usa…
View article: Face coverings and respiratory tract droplet dispersion: Face Covering Effectiveness
Face coverings and respiratory tract droplet dispersion: Face Covering Effectiveness Open
Respiratory droplets are the primary transmission route for SARS-CoV-2, a principle which drives social distancing guidelines Evidence suggests that virus transmission can be reduced by face coverings, but robust evidence for how mask usa…
View article: Face Coverings and Respiratory Tract Droplet Dispersion
Face Coverings and Respiratory Tract Droplet Dispersion Open
Respiratory droplets are the primary transmission route for SARS-CoV-2. Evidence suggests that virus transmission can be reduced by face coverings, but robust evidence for how mask usage might affect safe distancing parameters is lacking. …
View article: Effects of corticosterone within the hypothalamic arcuate nucleus on food intake and body weight in male rats
Effects of corticosterone within the hypothalamic arcuate nucleus on food intake and body weight in male rats Open
View article: Maternal Glucocorticoid Metabolism Across Pregnancy: A Potential Mechanism Underlying Fetal Glucocorticoid Exposure
Maternal Glucocorticoid Metabolism Across Pregnancy: A Potential Mechanism Underlying Fetal Glucocorticoid Exposure Open
Context Across pregnancy, maternal serum cortisol levels increase up to 3-fold. It is not known whether maternal peripheral cortisol metabolism and clearance change across pregnancy or influence fetal cortisol exposure and development. Obj…
View article: Face coverings and respiratory tract droplet dispersion: Dataset 4: Shadow Imaging
Face coverings and respiratory tract droplet dispersion: Dataset 4: Shadow Imaging Open
Face coverings and respiratory tract droplet dispersion Supplementary Information. # Background: # Respiratory droplets are the primary transmission route for SARS-CoV-2; a principle which drives social distancing guidelines. Evidence sugg…
View article: Face coverings and respiratory tract droplet dispersion: Dataset 1: UV light test - droplets deposition images
Face coverings and respiratory tract droplet dispersion: Dataset 1: UV light test - droplets deposition images Open
"Face coverings and respiratory tract droplet dispersion" Supplementary Information. # Background: # Respiratory droplets are the primary transmission route for SARS-CoV-2; a principle which drives social distancing guidelines. Evidence su…
View article: Face coverings and respiratory tract droplet dispersion: Dataset 3: Laser tests - droplets path images
Face coverings and respiratory tract droplet dispersion: Dataset 3: Laser tests - droplets path images Open
Face coverings and respiratory tract droplet dispersion Supplementary Information. # Background: # Respiratory droplets are the primary transmission route for SARS-CoV-2; a principle which drives social distancing guidelines. Evidence sugg…
View article: Face coverings and respiratory tract droplet dispersion: Dataset 2: Microscopy tests - droplets deposition images
Face coverings and respiratory tract droplet dispersion: Dataset 2: Microscopy tests - droplets deposition images Open
Face coverings and respiratory tract droplet dispersion Supplementary Information. # Background: # Respiratory droplets are the primary transmission route for SARS-CoV-2; a principle which drives social distancing guidelines. Evidence sugg…
View article: Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments
Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments Open
STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on…
View article: Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5
Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5 Open
Deficiency in cytochrome P450 (CYP) 7B1, also known as oxysterol 7α-hydroxylase, in humans leads to hereditary spastic paraplegia type 5 (SPG5) and in some cases in infants to liver disease. SPG5 is medically characterized by loss of motor…
View article: SUN-112 Arcuate 11-Betahydroxysteroid Dehydrogenase Type1 Regulates Energy Homeostasis
SUN-112 Arcuate 11-Betahydroxysteroid Dehydrogenase Type1 Regulates Energy Homeostasis Open
Introduction: Despite the ongoing increase in the prevalence of obesity, there are few licensed anti-obesity medications, and these therapies have limited efficacy and significant side effects. Therefore, new treatments are being developed…
View article: Predictors of Nephrolithiasis, Osteoporosis, and Mortality in Primary Hyperparathyroidism
Predictors of Nephrolithiasis, Osteoporosis, and Mortality in Primary Hyperparathyroidism Open
Context Primary hyperparathyroidism (PHPT) has a prevalence of 0.86% and is associated with increased risk of nephrolithiasis and osteoporosis. PHPT may also be associated with increased risk of cardiovascular disease and mortality. Object…
View article: Presentation, diagnostic assessment and surgical outcomes in primary hyperparathyroidism: a single centre’s experience
Presentation, diagnostic assessment and surgical outcomes in primary hyperparathyroidism: a single centre’s experience Open
Objective Primary hyperparathyroidism (PHPT) is a common reason for referral to endocrinology but the evidence base guiding assessment is limited. We evaluated the clinical presentation, assessment and subsequent management in PHPT. Design…
View article: Correction: Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness
Correction: Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness Open
View article: Corrigendum: Dynamic Changes in DNA Methylation Occur during the First Year of Life in Preterm Infants
Corrigendum: Dynamic Changes in DNA Methylation Occur during the First Year of Life in Preterm Infants Open
[This corrects the article on p. 158 in vol. 7, PMID: 28018293.].
View article: Midlife stress alters memory and mood-related behaviors in old age: Role of locally activated glucocorticoids
Midlife stress alters memory and mood-related behaviors in old age: Role of locally activated glucocorticoids Open
View article: 11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation
11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation Open
Chronically elevated glucocorticoid levels impair cognition and are pro-inflammatory in the brain. Deficiency or inhibition of 11β-hydroxysteroid dehydrogenase type-1 (11β-HSD1), which converts inactive into active glucocorticoids, protect…