Jonathan Ramsay
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View article: Idiopathic male infertility – what are we missing?
Idiopathic male infertility – what are we missing? Open
Couple's infertility is a rising issue worldwide affecting approximately 15% of couples. In 50% of the couples, a male factor infertility can be identified. Moreover, 30% of the men exhibit reduced sperm quality without any identifiable re…
View article: Global Practice Patterns and Variations in the Medical and Surgical Management of Non-Obstructive Azoospermia: Results of a World-Wide Survey, Guidelines and Expert Recommendations
Global Practice Patterns and Variations in the Medical and Surgical Management of Non-Obstructive Azoospermia: Results of a World-Wide Survey, Guidelines and Expert Recommendations Open
This is the largest survey to date on the real-world medical and surgical management of NOA by reproductive experts. It demonstrates a diverse practice pattern and highlights the need for evidence-based international consensus guidelines.
View article: Global Practice Patterns in the Evaluation of Non-Obstructive Azoospermia: Results of a World-Wide Survey and Expert Recommendations
Global Practice Patterns in the Evaluation of Non-Obstructive Azoospermia: Results of a World-Wide Survey and Expert Recommendations Open
This expert survey, encompassing 367 participants from 49 countries, unveils congruence with recommended guidelines in NOA diagnosis. However, noteworthy disparities in practices suggest a need for evidence-based, international consensus g…
View article: Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data
Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data Open
Purpose: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-per…
View article: O-252 Next generation sequencing analysis of the seminal microbiome in male partners of women with idiopathic recurrent pregnancy loss: results of a prospective cohort study
O-252 Next generation sequencing analysis of the seminal microbiome in male partners of women with idiopathic recurrent pregnancy loss: results of a prospective cohort study Open
Study question Is there an association between the semen microbiome, seminal reactive oxygen species (ROS) and DNA fragmentation in men with recurrent pregnancy loss (RPL)? Summary answer This pilot study outlines the subtle role that micr…
View article: Consensus and Diversity in the Management of Varicocele for Male Infertility: Results of a Global Practice Survey and Comparison with Guidelines and Recommendations
Consensus and Diversity in the Management of Varicocele for Male Infertility: Results of a Global Practice Survey and Comparison with Guidelines and Recommendations Open
This study is the largest global survey performed to date on the clinical management of varicocele for male infertility. It demonstrates: 1) a wide disagreement in the approach to varicocele management, 2) large gaps in the clinical practi…
View article: Post-Vasectomy Semen Analysis: Optimizing Laboratory Procedures and Test Interpretation through a Clinical Audit and Global Survey of Practices
Post-Vasectomy Semen Analysis: Optimizing Laboratory Procedures and Test Interpretation through a Clinical Audit and Global Survey of Practices Open
Our results highlighted varying clinical practices around the globe, with controversy over the significance of non-motile sperm in the PVSA sample. Our data suggest that less stringent AUA guidelines would help improve test compliance. A l…
View article: Sperm Vitality and Necrozoospermia: Diagnosis, Management, and Results of a Global Survey of Clinical Practice
Sperm Vitality and Necrozoospermia: Diagnosis, Management, and Results of a Global Survey of Clinical Practice Open
Sperm vitality testing is a basic semen examination that has been described in the World Health Organization (WHO) Laboratory Manual for the Examination and Processing of Human Semen from its primary edition, 40 years ago. Several methods …
View article: Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training
Sperm Morphology Assessment in the Era of Intracytoplasmic Sperm Injection: Reliable Results Require Focus on Standardization, Quality Control, and Training Open
Semen analysis is the first, and frequently, the only step in the evaluation of male fertility. Although the laboratory procedures are conducted according to the World Health Organization (WHO) guidelines, semen analysis and especially spe…
View article: Relevance of Leukocytospermia and Semen Culture and Its True Place in Diagnosing and Treating Male Infertility
Relevance of Leukocytospermia and Semen Culture and Its True Place in Diagnosing and Treating Male Infertility Open
The current WHO 2010 manual for human semen analysis defines leukocytospermia as the presence of peroxidase-positive leukocytes at a concentration >1×106/mL of semen. Granular leukocytes when activated are capable of generating high levels…
View article: A Comprehensive Guide to Sperm Recovery in Infertile Men with Retrograde Ejaculation
A Comprehensive Guide to Sperm Recovery in Infertile Men with Retrograde Ejaculation Open
Retrograde ejaculation (RE) is a condition defined as the backward flow of the semen during ejaculation, and when present can result in male infertility. RE may be partial or complete, resulting in either low seminal volume or complete abs…
View article: Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines
Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines Open
Sperm DNA fragmentation (SDF) is implicated in male infertility and adverse reproductive outcomes. With the publication of many studies regarding the etiologies and contributors to SDF, as well as the effects of SDF, guidelines are necessa…
View article: A Global Survey of Reproductive Specialists to Determine the Clinical Utility of Oxidative Stress Testing and Antioxidant Use in Male Infertility
A Global Survey of Reproductive Specialists to Determine the Clinical Utility of Oxidative Stress Testing and Antioxidant Use in Male Infertility Open
This study is the largest online survey performed to date on this topic and demonstrates 1) a worldwide understanding of the importance of this therapeutic option, and 2) a widely prevalent use of antioxidants to treat male infertility. Fi…
View article: Baseline levels of seminal reactive oxygen species predict improvements in sperm function following antioxidant therapy in men with infertility
Baseline levels of seminal reactive oxygen species predict improvements in sperm function following antioxidant therapy in men with infertility Open
Background Poor sperm function is a major cause of infertility. There is no drug therapy to improve sperm function. Semen oxidative stress is a recently identified pathway for sperm damage. Commercial antioxidants such as L‐carnitine and a…
View article: The semen microbiome and its impact on sperm function and male fertility: A systematic review and meta‐analysis
The semen microbiome and its impact on sperm function and male fertility: A systematic review and meta‐analysis Open
Background Male factor is attributable in up to 50% of cases of infertility. In vitro studies demonstrate that bacteria can negatively impact sperm function. The use of next‐generation sequencing techniques has provided a better understand…
View article: Burdens and awareness of adverse self‐reported lifestyle factors in men with sub‐fertility: A cross‐sectional study in 1149 men
Burdens and awareness of adverse self‐reported lifestyle factors in men with sub‐fertility: A cross‐sectional study in 1149 men Open
Background There are no current pharmacological therapies to improve sperm quality in men with sub‐fertility. Reducing the exposure to lifestyle risk factor (LSF) is currently the only intervention for improving sperm quality in men with s…
View article: PD25-05 ASSESSING THE IMPACT OF MALE CANCERS ON TOTAL MOTILE SPERM COUNT
PD25-05 ASSESSING THE IMPACT OF MALE CANCERS ON TOTAL MOTILE SPERM COUNT Open
You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II (PD25)1 Apr 2020PD25-05 ASSESSING THE IMPACT OF MALE CANCERS ON TOTAL MOTILE SPERM COUNT Tharu Tharakan, Miles Smith*, Thomas Stroud, Ee Teng Goh, Monica Figueiredo…
View article: PD25-07 ASSESSING TRENDS IN SPERM CRYOPRESERVATION AT A TERTIARY REFERRAL CENTRE OVER 25-YEARS
PD25-07 ASSESSING TRENDS IN SPERM CRYOPRESERVATION AT A TERTIARY REFERRAL CENTRE OVER 25-YEARS Open
You have accessJournal of UrologyInfertility: Epidemiology & Evaluation II (PD25)1 Apr 2020PD25-07 ASSESSING TRENDS IN SPERM CRYOPRESERVATION AT A TERTIARY REFERRAL CENTRE OVER 25-YEARS Tharu Tharakan, Miles Smith*, Thomas Stroud, Ee Teng …
View article: Novel use of COMET parameters of sperm DNA damage may increase its utility to diagnose male infertility and predict live births following both IVF and ICSI
Novel use of COMET parameters of sperm DNA damage may increase its utility to diagnose male infertility and predict live births following both IVF and ICSI Open
STUDY QUESTION Do the Comet parameters of the proportions of sperm with low or high DNA damage improve the power of the test in the diagnosis of male infertility and/or prediction of IVF and ICSI live birth rates? SUMMARY ANSWER The mean C…
View article: MP75-01 EVIDENCE THAT TESTICULAR SPERM HAS IMPROVED DNA INTEGRITY COMPARED TO EJACULATED SPERM IN INFERTILE MEN
MP75-01 EVIDENCE THAT TESTICULAR SPERM HAS IMPROVED DNA INTEGRITY COMPARED TO EJACULATED SPERM IN INFERTILE MEN Open
You have accessJournal of UrologyInfertility: Basic Research & Pathophysiology (MP75)1 Apr 2019MP75-01 EVIDENCE THAT TESTICULAR SPERM HAS IMPROVED DNA INTEGRITY COMPARED TO EJACULATED SPERM IN INFERTILE MEN Lona Vyas*, Sheena Lewis, Tharu …
View article: A Comparison Between Two Assays for Measuring Seminal Oxidative Stress and their Relationship with Sperm DNA Fragmentation and Semen Parameters
A Comparison Between Two Assays for Measuring Seminal Oxidative Stress and their Relationship with Sperm DNA Fragmentation and Semen Parameters Open
Oxidative stress (OS) is a significant cause of DNA fragmentation and is associated with poor embryo development and recurrent miscarriage. The aim of this study was to compare two different methods for assessing seminal OS and their abili…
View article: Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility
Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility Open
Despite advances in the field of male reproductive health, idiopathic male infertility, in which a man has altered semen characteristics without an identifiable cause and there is no female factor infertility, remains a challenging conditi…