Jonathan Sandoe
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View article: Faux paw: Capnocytophaga canimorsus endocarditis following a dog lick: A case report
Faux paw: Capnocytophaga canimorsus endocarditis following a dog lick: A case report Open
Capnocytophaga canimorsus (C. canimorsus) is a fastidious Gram-negative bacterium found in the mouths of dogs and cats. It is a rare cause of infective endocarditis, when it is often associated with dog bites. We present a case of C. canim…
View article: ElastoMeric Infusion Pumps for Hospital AntibioTICs (EMPHATIC): A Feasibility Study
ElastoMeric Infusion Pumps for Hospital AntibioTICs (EMPHATIC): A Feasibility Study Open
Background: Elastomeric infusion pumps (EMPs) are safe and effective for administering outpatient intravenous (IV) antibiotics. We hypothesized that EMPs may provide benefits in the inpatient setting. This study aimed to assess the feasibi…
View article: S. aureus biofilm disruption using ultrasound and microbubbles: Influence of radiation force, bubble dynamics and biofilm growth conditions
S. aureus biofilm disruption using ultrasound and microbubbles: Influence of radiation force, bubble dynamics and biofilm growth conditions Open
View article: Faux paw: Capnocytophaga canimorsus endocarditis following a dog lick: A case report
Faux paw: Capnocytophaga canimorsus endocarditis following a dog lick: A case report Open
Capnocytophaga canimorsus (C. canimorsus) is a fastidious Gram-negative bacterium found in the mouths of dogs and cats. It is a rare cause of infective endocarditis, when it is often associated with dog bites. We present a case of C. canim…
View article: Assessing a penicillin allergy de-labelling implementation intervention in a UK hospital: a process evaluation reporting healthcare workers’ experiences
Assessing a penicillin allergy de-labelling implementation intervention in a UK hospital: a process evaluation reporting healthcare workers’ experiences Open
Background and objectives Penicillin allergy (penA) records prevent first-line penicillin antibiotic use, but more than 90% are incorrect after formal testing and can be removed (‘de-labelled’). We developed an implementation intervention …
View article: Procalcitonin to guide antibiotic use during the first wave of COVID-19 in English and Welsh hospitals: integration and triangulation of findings from quantitative and qualitative sources
Procalcitonin to guide antibiotic use during the first wave of COVID-19 in English and Welsh hospitals: integration and triangulation of findings from quantitative and qualitative sources Open
Aim To integrate the quantitative and qualitative data collected as part of the PEACH (Procalcitonin: Evaluation of Antibiotic use in COVID-19 Hospitalised patients) study, which evaluated whether procalcitonin (PCT) testing should be used…
View article: Penicillin allergy de-labelling implementation intervention in a UK hospital: a process evaluation, the patient experience
Penicillin allergy de-labelling implementation intervention in a UK hospital: a process evaluation, the patient experience Open
Background Penicillin allergy (penA) records are common, but true penA is rare. PenA records are associated with broad spectrum antibiotic prescribing and negative patient outcomes. We developed a behavioural intervention package to suppor…
View article: Description of the combined evidence-based, theory-based and person-based approaches used to develop a behavioural intervention package to support non-allergist healthcare workers to remove incorrect penicillin allergy records from medical and surgical adult inpatients in a UK hospital
Description of the combined evidence-based, theory-based and person-based approaches used to develop a behavioural intervention package to support non-allergist healthcare workers to remove incorrect penicillin allergy records from medical and surgical adult inpatients in a UK hospital Open
Objectives To develop a behavioural intervention package to support non-allergist healthcare workers (HCWs) to remove incorrect penA records from medical and surgical adult inpatients. This paper describes the development of the penicillin…
View article: Penicillin allergy assessment pathway versus usual clinical care for primary care patients with a penicillin allergy record in the UK (ALABAMA): an open-label, multicentre, randomised controlled trial
Penicillin allergy assessment pathway versus usual clinical care for primary care patients with a penicillin allergy record in the UK (ALABAMA): an open-label, multicentre, randomised controlled trial Open
View article: O03 Antimicrobial pharmacist led penicillin allergy de-labelling (PADL) is safe and effective at removing low risk penA records
O03 Antimicrobial pharmacist led penicillin allergy de-labelling (PADL) is safe and effective at removing low risk penA records Open
Objectives To implement a penicillin allergy de-labelling (PADL) intervention in adult medical and surgical specialties, delivered by both the wider clinical teams and antimicrobial stewardship (AMS) pharmacists. Methods The core (PADL) im…
View article: Patients’ acceptance of a penicillin allergy de-labelling programme in primary care: a qualitative study
Patients’ acceptance of a penicillin allergy de-labelling programme in primary care: a qualitative study Open
Background About 6% of the UK general practice population has a record of a penicillin allergy but fewer than 10% of these people are likely to be truly allergic. Consequently, a significant portion of the population is denied first-line a…
View article: Direct oral penicillin challenge in secondary care with low-risk patients: the SPACE mixed-methods study with cost-effectiveness analysis
Direct oral penicillin challenge in secondary care with low-risk patients: the SPACE mixed-methods study with cost-effectiveness analysis Open
Some text in this abstract has been adapted from Krishna MT, Bhogal R, Ng BY, Kildonaviciute K, Jani YH, Williams I, et al . A multicentre observational study to investigate feasibility of a direct oral penicillin challenge in de-labelling…
View article: Healthcare professionals' experiences of de-labelling erroneous penicillin allergy records in general practice: a qualitative study
Healthcare professionals' experiences of de-labelling erroneous penicillin allergy records in general practice: a qualitative study Open
Background Penicillin allergy (PenA) prevalence is approximately 6%, but fewer than 10% of these people are expected to be truly allergic. Consequently, a significant proportion of the population are prescribed alternative antibiotics with…
View article: Procalcitonin evaluation of antibiotic use in COVID-19 hospitalised patients: The PEACH mixed methods study
Procalcitonin evaluation of antibiotic use in COVID-19 hospitalised patients: The PEACH mixed methods study Open
Background Early in the COVID-19 pandemic, there was concern about potentially unnecessary antibiotic prescribing in the National Health Service. Procalcitonin testing was being used in some hospitals to guide antibiotic use. This study ai…
View article: Combination therapy versus monotherapy: retrospective analysis of antibiotic treatment of enterococcal endocarditis
Combination therapy versus monotherapy: retrospective analysis of antibiotic treatment of enterococcal endocarditis Open
View article: Characteristics, risk factors and clinical impact of penicillin and other antibiotic allergies in adults in the UK General Practice: A population-based cohort study
Characteristics, risk factors and clinical impact of penicillin and other antibiotic allergies in adults in the UK General Practice: A population-based cohort study Open
Penicillin and other antibiotic allergy labels are common and lead to radical change in the antibiotic prescribing practices and are associated with resistant and healthcare associated infections.
View article: A rapid literature review of the impact of penicillin allergy on antibiotic resistance
A rapid literature review of the impact of penicillin allergy on antibiotic resistance Open
Background Antimicrobial resistance (AMR) is caused by the use and misuse of antibiotics. AMR is a global health concern, to which penicillin allergy (penA) labels appear to contribute. Patients who have penA labels are treated with non-pe…
View article: Adaptation of the WHO AWaRe (Access, Watch, Reserve) antibiotic classification to support national antimicrobial stewardship priorities in the UK: findings from a modified Delphi approach to achieve expert consensus
Adaptation of the WHO AWaRe (Access, Watch, Reserve) antibiotic classification to support national antimicrobial stewardship priorities in the UK: findings from a modified Delphi approach to achieve expert consensus Open
Objectives In 2017, the WHO introduced the AWaRe (Access, Watch and Reserve) classification of antibiotics to support antibiotic stewardship (AMS) at local, national and global levels. We assessed the categorization of each of the antibiot…
View article: A retrospective propensity-score-matched cohort study of the impact of procalcitonin testing on antibiotic use in hospitalized patients during the first wave of COVID-19
A retrospective propensity-score-matched cohort study of the impact of procalcitonin testing on antibiotic use in hospitalized patients during the first wave of COVID-19 Open
Background Procalcitonin (PCT) is a blood marker used to help diagnose bacterial infections and guide antibiotic treatment. PCT testing was widely used/adopted during the COVID-19 pandemic in the UK. Objectives Primary: to measure the diff…
View article: Factors influencing implementation and adoption of direct oral penicillin challenge for allergy delabelling: a qualitative evaluation
Factors influencing implementation and adoption of direct oral penicillin challenge for allergy delabelling: a qualitative evaluation Open
Background Over 95% of penicillin allergy labels are inaccurate and may be addressed in low-risk patients using direct oral penicillin challenge (DPC). This study explored the behaviour, attitudes and acceptability of patients, healthcare …
View article: P29 Understanding penicillin allergy assessment and delabelling massive open online community
P29 Understanding penicillin allergy assessment and delabelling massive open online community Open
Background PenA records are associated with antibiotic prescribing that is potentially less effective and more harmful. The paucity of allergy specialists worldwide has prompted non-allergist delivered penicillin allergy delabelling (PADL)…
View article: Narrative review of recent developments and the future of penicillin allergy de-labelling by non-allergists
Narrative review of recent developments and the future of penicillin allergy de-labelling by non-allergists Open
This article outlines recent developments in non-allergist delivered penicillin allergy de-labelling (PADL), discusses remaining controversies and uncertainties and explores the future for non-allergist delivered PADL. Recent developments …
View article: Introducing the UK Antimicrobial Registry (UKAR) study: providing real world data on new antimicrobials to support antimicrobial stewardship and tackle antimicrobial resistance
Introducing the UK Antimicrobial Registry (UKAR) study: providing real world data on new antimicrobials to support antimicrobial stewardship and tackle antimicrobial resistance Open
The UK Antimicrobial Registry (UKAR) has been developed to capture data on real world usage of antimicrobial agents with an initial focus on those used to treat drug-resistant infections. Several industry partners have committed support fo…
View article: The appropriateness of penicillin allergy de-labelling by non-allergist clinical ward teams
The appropriateness of penicillin allergy de-labelling by non-allergist clinical ward teams Open
Using the allergy risk tool, most patients with PenA records were exposed to penicillin appropriately. However, patients meeting high-risk criteria were also exposed to penicillin when the tool excluded them. PenA assessment needs to be ca…
View article: The cost-effectiveness of procalcitonin for guiding antibiotic prescribing in individuals hospitalized with COVID-19: part of the PEACH study
The cost-effectiveness of procalcitonin for guiding antibiotic prescribing in individuals hospitalized with COVID-19: part of the PEACH study Open
Background Many hospitals introduced procalcitonin (PCT) testing to help diagnose bacterial coinfection in individuals with COVID-19, and guide antibiotic decision-making during the COVID-19 pandemic in the UK. Objectives Evaluating cost-e…
View article: Eliciting the barriers and enablers towards anaesthetists giving penicillin-based antibiotic prophylaxis to low-risk patients who have had their penicillin allergy label removed as part of a preoperative delabelling process
Eliciting the barriers and enablers towards anaesthetists giving penicillin-based antibiotic prophylaxis to low-risk patients who have had their penicillin allergy label removed as part of a preoperative delabelling process Open
Background Some penicillin allergy labels can be removed by non-allergy specialists by direct oral challenge, but there is reluctance amongst anaesthetists to give penicillin to these patients. We aimed to assess anaesthetist beliefs about…
View article: A multicentre observational study to investigate feasibility of a direct oral penicillin challenge in de-labelling ‘low risk’ patients with penicillin allergy by non-allergy healthcare professionals (SPACE study): Implications for healthcare systems
A multicentre observational study to investigate feasibility of a direct oral penicillin challenge in de-labelling ‘low risk’ patients with penicillin allergy by non-allergy healthcare professionals (SPACE study): Implications for healthcare systems Open
DPCs can be delivered by non-allergy HCPs. A high proportion of patients with PALs did not progress in the study pathway. Strategies to deliver DPC at optimal points of the care pathway are needed to enhance uptake. Elective settings offer…
View article: P15 UK Antimicrobial Registry Study: progress to date
P15 UK Antimicrobial Registry Study: progress to date Open
Background Effective antimicrobial stewardship is key in the fight against antimicrobial resistance, a key element of which is the surveillance of antimicrobial use and antimicrobial resistance. In addition to quantitative analysis of anti…
View article: Non-allergist healthcare workers views on delivering a penicillin allergy de-labelling inpatient pathway: identifying the barriers and enablers
Non-allergist healthcare workers views on delivering a penicillin allergy de-labelling inpatient pathway: identifying the barriers and enablers Open
Background Non-allergist delivered PADL is supported by UK and World Health Organization guidelines but is not yet routine in UK hospitals. Understanding the views of healthcare workers (HCWs) on managing patients with penA records and exp…
View article: Experiences of an inpatient penicillin allergy de-labelling pathway: capturing the patient voice
Experiences of an inpatient penicillin allergy de-labelling pathway: capturing the patient voice Open
Background Non-allergist-delivered penicillin allergy de-labelling (PADL) is supported by UK and other national guidelines but is not yet routine practice in UK hospitals. Those who have undergone PADL report high rates of acceptance, but …