Jonathan Sandy
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View article: Orofacial cleft repair: A clinical model for studying genetic contribution to scar severity
Orofacial cleft repair: A clinical model for studying genetic contribution to scar severity Open
Scars resulting from surgical repair of cleft lip and palate provide a unique model in humans for studying factors that affect the severity of scarring. Anatomically, clefts of the lip and palate are consistent in location and are treated …
View article: Comparison of secondary surgery before and after centralisation of cleft services in the UK: a whole-island cross-sectional analysis
Comparison of secondary surgery before and after centralisation of cleft services in the UK: a whole-island cross-sectional analysis Open
Objective Cleft lip and palate significantly impact a child’s speech and facial appearance. Children undergo cleft repairs in infancy, but poor results from these initial repairs often lead to secondary surgery. In the late 1990s, cleft ca…
View article: Genetic heterogeneity and homogeneity among orofacial cleft subtypes: genome-wide association studies in the cleft collective
Genetic heterogeneity and homogeneity among orofacial cleft subtypes: genome-wide association studies in the cleft collective Open
Several genome wide association studies (GWASs) of orofacial cleft have been conducted. However only a few such studies to date have combined all cleft cases, focused on subtypes other than non-syndromic cleft lip with/without cleft palate…
View article: Copy number variants and their implications for developmental and behavioural problems in cleft lip and/or palate
Copy number variants and their implications for developmental and behavioural problems in cleft lip and/or palate Open
Cleft lip and/or palate (CL/P) is the most common craniofacial congenital anomaly and has been associated with higher risk of neurodevelopmental and behavioural problems indicating potential shared genetic factors between CL/P and neurodev…
View article: Genetic Heterogeneity and Homogeneity Among Orofacial Cleft Subtypes: Genome-Wide Association Studies in the Cleft Collective
Genetic Heterogeneity and Homogeneity Among Orofacial Cleft Subtypes: Genome-Wide Association Studies in the Cleft Collective Open
Several genome wide association studies (GWASs) of orofacial cleft have been conducted, however the majority of studies to date have restricted their analysis to non-syndromic cleft lip with/without cleft palate and have not analysed all o…
View article: Copy Number Variants and their Implications for Developmental and Behavioural Problems in Cleft Lip and/or Palate
Copy Number Variants and their Implications for Developmental and Behavioural Problems in Cleft Lip and/or Palate Open
Cleft lip and/or palate (CL/P) is the most common craniofacial congenital anomaly and has been associated with higher risk of neurodevelopmental and behavioural problems indicating potential shared genetic factors between CL/P and neurodev…
View article: Dental Arch Relationship Outcomes of 5-Year-Olds Born With Unilateral Cleft Lip and Palate Following the Centralization of Cleft Services
Dental Arch Relationship Outcomes of 5-Year-Olds Born With Unilateral Cleft Lip and Palate Following the Centralization of Cleft Services Open
To investigate the interdental arch relationship outcomes of 5-year-old children with unilateral cleft lip and palate (UCLP) before and after centralization of cleft services in the United Kingdom (UK) using the modified Huddart-Bodenham i…
View article: Predicting Syndromic Status Based on Longitudinal Data from Parental Reports of the Presence of Additional Structural and Functional Anomalies in Children Born with an Orofacial Cleft
Predicting Syndromic Status Based on Longitudinal Data from Parental Reports of the Presence of Additional Structural and Functional Anomalies in Children Born with an Orofacial Cleft Open
Background: Orofacial clefts are the most common craniofacial congenital malformation in humans. Approximately 30% of clefts arise as part of a syndrome or sequence, characterised by co-existing structural and functional anomalies. Many sy…
View article: Hospital-based Costs to the National Health Service (UK) for Children and Adolescents Born with Cleft from Birth to 20 Years
Hospital-based Costs to the National Health Service (UK) for Children and Adolescents Born with Cleft from Birth to 20 Years Open
Objective The primary aim was to assess the cost (£) to the National Health Service (NHS) of hospital treatment for individuals born with bilateral cleft lip and palate (BCLP), unilateral cleft lip and palate (UCLP), and cleft palate (CP),…
View article: The Cleft Collective: protocol for a longitudinal prospective cohort study
The Cleft Collective: protocol for a longitudinal prospective cohort study Open
Introduction Cleft lip and/or palate (CL/P) affects 1 in 700 live births globally. Children born with CL/P and their families face various challenges throughout the child’s development. Extant research is often limited by small numbers and…
View article: Aerosol Production during Resin Removal with Rotary Instruments
Aerosol Production during Resin Removal with Rotary Instruments Open
Following the completion of a course of fixed appliance treatment, it is necessary to remove the brackets, bands and tubes along with any residual adhesive from the teeth. The particulates produced have the potential to be inhaled by the p…
View article: Prevalence and Factors Associated with Behavioral Problems in 5-Year-Old Children Born with Cleft Lip and/or Palate from the Cleft Collective
Prevalence and Factors Associated with Behavioral Problems in 5-Year-Old Children Born with Cleft Lip and/or Palate from the Cleft Collective Open
Objectives To determine the UK prevalence of behavioral problems in 5-year-old children born with isolated or syndromic cleft lip and/or palate (CL/P) compared to the general population and identify potentially associated factors. Design O…
View article: The impact of changing cigarette smoking habits and smoke-free legislation on orofacial cleft incidence in the United Kingdom: Evidence from two time-series studies
The impact of changing cigarette smoking habits and smoke-free legislation on orofacial cleft incidence in the United Kingdom: Evidence from two time-series studies Open
Background Both active and passive cigarette smoking have previously been associated with orofacial cleft aetiology. We aimed to analyse the impact of declining active smoking prevalence and the implementation of smoke-free legislation on …
View article: Maternal Cigarette Smoking and Cleft Lip and Palate: A Systematic Review and Meta-Analysis
Maternal Cigarette Smoking and Cleft Lip and Palate: A Systematic Review and Meta-Analysis Open
Objectives A systematic review and meta-analysis to determine the association between active maternal smoking and cleft lip and palate etiology. Data sources Medline, Embase, Web of Science and the Cochrane Library from inception to Novemb…
View article: Prevalence and Factors Associated with Behavioural Problems in 5-year-old Children Born with Cleft Lip and/or Palate from the Cleft Collective
Prevalence and Factors Associated with Behavioural Problems in 5-year-old Children Born with Cleft Lip and/or Palate from the Cleft Collective Open
Objectives We determined the prevalence of behavioural problems in 5-year-old children born with Cleft Lip and/or Palate (CL/P) and compared it to the prevalence in general population samples. We also identified risk factors for behavioura…
View article: Changes in the Transverse Dimension of the Maxillary Arch of 5-Year-Olds Born With UCLP Since the Introduction of Nationwide Guidance
Changes in the Transverse Dimension of the Maxillary Arch of 5-Year-Olds Born With UCLP Since the Introduction of Nationwide Guidance Open
Objective: To determine whether the transverse dimensions of the maxillary arch of 5-year-old children with unilateral cleft lip and palate (UCLP) have changed following centralization of cleft services in the United Kingdom. Design: Retro…
View article: The impact of changing smoking habits and smoke-free legislation on orofacial cleft incidence in the United Kingdom: evidence from two time-series studies
The impact of changing smoking habits and smoke-free legislation on orofacial cleft incidence in the United Kingdom: evidence from two time-series studies Open
Objectives To analyse the association between active and passive cigarette smoking and the incidence of children born with a cleft lip and/or palate within the United Kingdom. Design First, a longitudinal time-series study was conducted wi…
View article: Maternal cigarette smoking and cleft lip and palate: A systematic review and meta-analysis
Maternal cigarette smoking and cleft lip and palate: A systematic review and meta-analysis Open
Objectives A systematic review and meta-analysis to determine the association between active maternal smoking and cleft lip and palate etiology. Data Sources Medline, Embase, Web of Science and the Cochrane database from inception to Novem…
View article: Educational Attainment of Children Born with Unilateral Cleft Lip and Palate in the United Kingdom
Educational Attainment of Children Born with Unilateral Cleft Lip and Palate in the United Kingdom Open
Objective: This study evaluated association between functional outcomes in children born with unilateral cleft lip and palate (UCLP) and educational attainment. Design: Cleft Care UK (CCUK) was a United Kingdom (UK) wide cross-sectional st…
View article: Cleft lip/palate and educational attainment: cause, consequence or correlation? A Mendelian randomization study
Cleft lip/palate and educational attainment: cause, consequence or correlation? A Mendelian randomization study Open
Background Previous studies have found that children born with a non-syndromic orofacial cleft have lower-than-average educational attainment. Differences could be due to a genetic predisposition to low intelligence and academic performanc…
View article: Range and timing of surgery, and surgical sequences used, in primary repair of complete unilateral cleft lip and palate: The Cleft Care UK study
Range and timing of surgery, and surgical sequences used, in primary repair of complete unilateral cleft lip and palate: The Cleft Care UK study Open
Objects To describe the range of surgery used to repair the lip and palate in the UK with specific interest in the sequence/timing used in complete unilateral cleft lip and palate (cUCLP). Setting and Sample Population The Cleft Care UK st…
View article: Is There a Correlation Between Nasolabial Appearance and Dentoalveolar Relationships in Patients With Repaired Unilateral Cleft Lip and Palate?
Is There a Correlation Between Nasolabial Appearance and Dentoalveolar Relationships in Patients With Repaired Unilateral Cleft Lip and Palate? Open
Objective: To determine whether a relationship exists between the aesthetic scores given to photographic records of the nasolabial region of patients with repaired unilateral cleft lip and palate (UCLP) and the 5-Year Olds’ Index scores of…
View article: Closer to the Truth on National Fistula Prevalence After Unilateral Complete Cleft Lip and Palate Repair? The Cleft Care UK Study
Closer to the Truth on National Fistula Prevalence After Unilateral Complete Cleft Lip and Palate Repair? The Cleft Care UK Study Open
Objectives: To (1) determine the prevalence of nonperialveolar palatal fistula up to age 5 following repair of unilateral cleft lip and palate (UCLP) in the United Kingdom, (2) examine the association of palatoplasty techniques with fistul…
View article: Evidence for DNA Methylation Mediating Genetic Liability to Non-Syndromic Cleft Lip/Palate
Evidence for DNA Methylation Mediating Genetic Liability to Non-Syndromic Cleft Lip/Palate Open
Evidence was found at VAX1 (10q25.3), LOC146880 (17q23.3) and NTN1 (17p13.1), that liability to nsCL/P and variation in DNA methylation might be driven by the same genetic variant, suggesting that genetic variation at these loci may increa…
View article: Cleft lip/palate and educational attainment: cause, consequence, or correlation? A Mendelian randomization study
Cleft lip/palate and educational attainment: cause, consequence, or correlation? A Mendelian randomization study Open
Importance Previous studies have found that children born with a non-syndromic form of cleft lip and/or palate have lower-than-average educational attainment. These differences could be due to a genetic predisposition to low intelligence a…
View article: Using Free Text From Medical Notes To Enrich a Longitudinal Cohort Study
Using Free Text From Medical Notes To Enrich a Longitudinal Cohort Study Open
IntroductionThe Cleft Collective Cohort study is the world's largest multidisciplinary cleft lip/palate research programme. Despite being one of the most common birth anomalies, the causes of clefting are unknown. Treatment involves a cons…