Jonathan Shum
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View article: Artificial intelligence-based epigenomic, transcriptomic and histologic signatures of tobacco use in oral squamous cell carcinoma
Artificial intelligence-based epigenomic, transcriptomic and histologic signatures of tobacco use in oral squamous cell carcinoma Open
Oral squamous cell carcinoma (OSCC) biomarker studies rarely employ multi-omic biomarker strategies and pertinent clinicopathologic characteristics to predict mortality. In this study we determine for the first time a combined epigenetic, …
View article: Repair of complex ovine segmental mandibulectomy utilizing customized tissue engineered bony flaps
Repair of complex ovine segmental mandibulectomy utilizing customized tissue engineered bony flaps Open
Craniofacial defects require a treatment approach that provides both robust tissues to withstand the forces of mastication and high geometric fidelity that allows restoration of facial architecture. When the surrounding soft tissue is comp…
View article: Brush swab as a noninvasive surrogate for tissue biopsies in oral cancer patients to develop clinically translatable epigenetic biomarkers
Brush swab as a noninvasive surrogate for tissue biopsies in oral cancer patients to develop clinically translatable epigenetic biomarkers Open
Background Oral squamous cell carcinoma (OSCC) has poor survival rates. There is a pressing need to develop more precise risk assessment methods to tailor clinical treatment. Epigenome-wide association studies in OSCC have not produced a v…
View article: Brush Swab As A Noninvasive Surrogate for Tissue Biopsies in Oral Cancer Patients To Develop Clinically Translatable Epigenetic Biomarkers
Brush Swab As A Noninvasive Surrogate for Tissue Biopsies in Oral Cancer Patients To Develop Clinically Translatable Epigenetic Biomarkers Open
Background Oral squamous cell carcinoma (OSCC) has poor survival rates. There is a pressing need to develop more precise risk assessment methods to tailor clinical treatment. Epigenome-wide association studies in OSCC have not produced a v…
View article: Modified karapandzic flap with radial forearm free flap to reconstruct a large composite upper lip and palate defect: Case report and anatomic study
Modified karapandzic flap with radial forearm free flap to reconstruct a large composite upper lip and palate defect: Case report and anatomic study Open
Functional reconstruction of a combined upper lip and palatal defect presents surgical challenges that differ from either type of defect in isolation. While useful in obtaining tissue coverage for large defects, free flaps lack the ability…
View article: A 2-stage Approach to Craniofacial Reconstruction in an Infected Ovine Mandibular Defect Model
A 2-stage Approach to Craniofacial Reconstruction in an Infected Ovine Mandibular Defect Model Open
INTRODUCTION: Reconstruction of infected mandibular defects is challenging due to the size and possible irregular shapes of defects, presence of pathogens, and the availability of suitable donor tissue. We have developed a 2-stage tissue e…
View article: Biomaterials-aided mandibular reconstruction using in vivo bioreactors
Biomaterials-aided mandibular reconstruction using in vivo bioreactors Open
Significance People may suffer large losses of mandibular (jaw) bone due to cancer, infection, trauma, congenital disease, or other disorders. The resulting bony defects are both aesthetically disfiguring and functionally disabling. We hav…
View article: The Impact of Smoke Exposure on the Clinical Phenotype of Alpha-1 Antitrypsin Deficiency in Ireland: Exploiting a National Registry to Understand a Rare Disease
The Impact of Smoke Exposure on the Clinical Phenotype of Alpha-1 Antitrypsin Deficiency in Ireland: Exploiting a National Registry to Understand a Rare Disease Open
Individuals with Alpha-1 antitrypsin deficiency (AATD) have mutations in the SERPINA1 gene causing genetic susceptibility to early onset lung and liver disease that may result in premature death. Environmental interactions have a significa…