Jonathan H. Siegel
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View article: Suppression of Low-Frequency Tones in the Organ of Corti Vibrations of the Basal Turn in the Mongolian Gerbil Cochlea
Suppression of Low-Frequency Tones in the Organ of Corti Vibrations of the Basal Turn in the Mongolian Gerbil Cochlea Open
Purpose The basilar membrane (BM) motion evoked by single or two-tone stimuli shows nonlinearity largely confined to the region of the traveling wave peak(s) with a passive and linear response basal to the peak. For the same stimuli, nonli…
View article: Frequency and level dependence of the middle ear acoustic reflex and its decay measured in wideband absorbance with contralateral narrowband noise elicitors
Frequency and level dependence of the middle ear acoustic reflex and its decay measured in wideband absorbance with contralateral narrowband noise elicitors Open
View article: What do recent discoveries in cochlear mechanics tell us about otoacoustic emissions?
What do recent discoveries in cochlear mechanics tell us about otoacoustic emissions? Open
Recent optical measurements of vibrations of the organ of Corti contrast with those of the basilar membrane in their larger amplitude and much wider bandwidth of active gain and nonlinearity [6-9, 15, 16, 19, 20]. A report by Ren and He (1…
View article: Entropy-based convergence rates of greedy algorithms
Entropy-based convergence rates of greedy algorithms Open
We present convergence estimates of two types of greedy algorithms in terms of the metric entropy of underlying compact sets. In the first part, we measure the error of a standard greedy reduced basis method for parametric PDEs by the metr…
View article: Data from A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Comparing the Tolerability and Efficacy of Ipilimumab Administered with or without Prophylactic Budesonide in Patients with Unresectable Stage III or IV Melanoma
Data from A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Comparing the Tolerability and Efficacy of Ipilimumab Administered with or without Prophylactic Budesonide in Patients with Unresectable Stage III or IV Melanoma Open
Purpose: Diarrhea (with or without colitis) is an immune-related adverse event (irAE) associated with ipilimumab. A randomized, double-blind, placebo-controlled, multicenter, multinational phase II trial was conducted to determine w…
View article: Data from A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Comparing the Tolerability and Efficacy of Ipilimumab Administered with or without Prophylactic Budesonide in Patients with Unresectable Stage III or IV Melanoma
Data from A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Comparing the Tolerability and Efficacy of Ipilimumab Administered with or without Prophylactic Budesonide in Patients with Unresectable Stage III or IV Melanoma Open
Purpose: Diarrhea (with or without colitis) is an immune-related adverse event (irAE) associated with ipilimumab. A randomized, double-blind, placebo-controlled, multicenter, multinational phase II trial was conducted to determine w…
View article: Supplementary Data from A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Comparing the Tolerability and Efficacy of Ipilimumab Administered with or without Prophylactic Budesonide in Patients with Unresectable Stage III or IV Melanoma
Supplementary Data from A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Comparing the Tolerability and Efficacy of Ipilimumab Administered with or without Prophylactic Budesonide in Patients with Unresectable Stage III or IV Melanoma Open
Supplementary Data from A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Comparing the Tolerability and Efficacy of Ipilimumab Administered with or without Prophylactic Budesonide in Patients with Unresectable Stage III or IV…
View article: Supplementary Data from A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Comparing the Tolerability and Efficacy of Ipilimumab Administered with or without Prophylactic Budesonide in Patients with Unresectable Stage III or IV Melanoma
Supplementary Data from A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Comparing the Tolerability and Efficacy of Ipilimumab Administered with or without Prophylactic Budesonide in Patients with Unresectable Stage III or IV Melanoma Open
Supplementary Data from A Randomized, Double-Blind, Placebo-Controlled, Phase II Study Comparing the Tolerability and Efficacy of Ipilimumab Administered with or without Prophylactic Budesonide in Patients with Unresectable Stage III or IV…
View article: Nesterov acceleration despite very noisy gradients
Nesterov acceleration despite very noisy gradients Open
We present a generalization of Nesterov's accelerated gradient descent algorithm. Our algorithm (AGNES) provably achieves acceleration for smooth convex and strongly convex minimization tasks with noisy gradient estimates if the noise inte…
View article: The influence of self-reported noise exposure on 2ƒ1-ƒ2 distortion product otoacoustic emission level, fine structure, and components in a normal-hearing population
The influence of self-reported noise exposure on 2ƒ1-ƒ2 distortion product otoacoustic emission level, fine structure, and components in a normal-hearing population Open
Distortion product otoacoustic emissions (DPOAEs) offer an outcome measure to consider for clinical detection and monitoring outer hair cell dysfunction as a result of noise exposure. This investigation detailed DPOAE characteristics and b…
View article: Time-to-event estimands and loss to follow-up in oncology in light of the estimands framework
Time-to-event estimands and loss to follow-up in oncology in light of the estimands framework Open
Time-to-event estimands are central to many oncology clinical trials. The estimand framework (addendum to the ICH E9 guideline) calls for precisely defining the treatment effect of interest to align with the clinical question of interest a…
View article: Distortion Product Otoacoustic Emission (DPOAE) Growth in Aging Ears with Clinically Normal Behavioral Thresholds
Distortion Product Otoacoustic Emission (DPOAE) Growth in Aging Ears with Clinically Normal Behavioral Thresholds Open
View article: Accelerated Optimization with Orthogonality Constraints
Accelerated Optimization with Orthogonality Constraints Open
We develop a generalization of Nesterov's accelerated gradient descent method\nwhich is designed to deal with orthogonality constraints. To demonstrate the\neffectiveness of our method, we perform numerical experiments which demonstrate\nt…
View article: Walking With Ears: Altered Auditory Feedback Impacts Gait Step Length in Older Adults
Walking With Ears: Altered Auditory Feedback Impacts Gait Step Length in Older Adults Open
Auditory feedback may provide the nervous system with valuable temporal (e. g., footstep sounds) and spatial (e.g., external reference sounds) information that can assist in the control of upright walking. As such, hearing loss may directl…
View article: Extended high frequency hearing and speech perception implications in adults and children
Extended high frequency hearing and speech perception implications in adults and children Open
View article: Effect of Middle-Ear Pathology on High-Frequency Ear Canal Reflectance Measurements in the Frequency and Time Domains
Effect of Middle-Ear Pathology on High-Frequency Ear Canal Reflectance Measurements in the Frequency and Time Domains Open
View article: The Association Between Physiological Noise Levels and Speech Understanding in Noise
The Association Between Physiological Noise Levels and Speech Understanding in Noise Open
Objectives: Traditionally, elevated hearing thresholds have been considered to be the main contributors to difficulty understanding speech in noise; yet, patients will often report difficulties with speech understanding in noise despite ha…
View article: Evanescent waves in simulated ear canals: Experimental demonstration and method for compensation
Evanescent waves in simulated ear canals: Experimental demonstration and method for compensation Open
Evanescent waves emerge from a small sound source that radiates into a waveguide with a larger cross-sectional area, but unlike planar waves, do not propagate far from the source. Evanescent waves thus contaminate in-ear calibration of aco…
View article: Spectral Ripples in Round-Window Cochlear Microphonics: Evidence for Multiple Generation Mechanisms
Spectral Ripples in Round-Window Cochlear Microphonics: Evidence for Multiple Generation Mechanisms Open
View article: Revisiting gender, race, and ear differences in peripheral auditory function
Revisiting gender, race, and ear differences in peripheral auditory function Open
Various measures of auditory function are reported to be superior in females as compared to males, in African American compared to Caucasian individuals, and in right compared to left ears. We re-examined the influence of these subject var…
View article: Does reticular lamina active gain explain broad suppression tuning of SFOAEs?
Does reticular lamina active gain explain broad suppression tuning of SFOAEs? Open
Stimulus frequency otoacoustic emissions (SFOAEs) appear to originate primarily in the cochlear region of the CF place of the evoking probe tone. It is commonly believed that SFOAE generation is a byproduct of the cochlear amplifier that e…
View article: Differentiating Middle Ear and Medial Olivocochlear Effects on Transient-Evoked Otoacoustic Emissions
Differentiating Middle Ear and Medial Olivocochlear Effects on Transient-Evoked Otoacoustic Emissions Open
View article: Using Cochlear Microphonic Potentials to Localize Peripheral Hearing Loss
Using Cochlear Microphonic Potentials to Localize Peripheral Hearing Loss Open
The cochlear microphonic (CM) is created primarily by the receptor currents of outer hair cells (OHCs) and may therefore be useful for identifying cochlear regions with impaired OHCs. However, the CM measured across the frequency range wit…
View article: Identifying the Origin of Effects of Contralateral Noise on Transient Evoked Otoacoustic Emissions in Unanesthetized Mice
Identifying the Origin of Effects of Contralateral Noise on Transient Evoked Otoacoustic Emissions in Unanesthetized Mice Open
View article: Tuning of SFOAEs Evoked by Low-Frequency Tones Is Not Compatible with Localized Emission Generation
Tuning of SFOAEs Evoked by Low-Frequency Tones Is Not Compatible with Localized Emission Generation Open
View article: Examining the role of the tectorial membrane in otoacoustic emission generation
Examining the role of the tectorial membrane in otoacoustic emission generation Open
A mouse lacking CEACAM16, a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family of proteins, shows changes in tectorial membrane (TM) structure including loss of a defined striated-sheet matrix, absence of…
View article: Effect of middle-ear pathology on high-frequency ear-canal reflectance measurements in the frequency and time domains
Effect of middle-ear pathology on high-frequency ear-canal reflectance measurements in the frequency and time domains Open
Wideband immittance and reflectance have not been well described at frequencies above 6-8 kHz, and past analyses of these measurements have focused on the responses to stimulus frequencies below 3-4 kHz, while ignoring high-frequency or ti…
View article: Low-frequency tone-pip-evoked otoacoustic emissions originate over a broad cochlear region in chinchillas
Low-frequency tone-pip-evoked otoacoustic emissions originate over a broad cochlear region in chinchillas Open
Otoacoustic emissions evoked with transient sounds (TEOAEs) are believed to originate within the tonotopic region of the stimulus in the cochlea via the same mechanisms as emissions evoked with single tones. However, we found that emission…
View article: High-frequency tone-pip-evoked otoacoustic emissions in chinchillas
High-frequency tone-pip-evoked otoacoustic emissions in chinchillas Open
We measured otoacoustic emissions in anesthetized chinchillas evoked by short (1 ms) high-frequency (4 kHz) tone-pips (TEOAE) using either a compression or suppression method to separate the stimulus from the emission. Both methods reveale…
View article: Modeling OAE responses to short tones
Modeling OAE responses to short tones Open
In 1999 Shera and Guinan postulated that otoacoustic emissions evoked by low-level transient stimuli are generated by coherent linear reflection (CRF or CLR). This hypothesis was tested experimentally, e.g., by Siegel and Charaziak[10] by …