Jonathan So
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View article: Development and evaluation of an artificial intelligence-based workflow for the prioritization of patient portal messages
Development and evaluation of an artificial intelligence-based workflow for the prioritization of patient portal messages Open
Objectives Accelerating demand for patient messaging has impacted the practice of many providers. Messages are not recommended for urgent medical issues, but some do require rapid attention. This presents an opportunity for artificial inte…
View article: 657. Impact of Oral Vancomycin Duration on <i>Clostridioides difficile</i> Recurrence in Patients Requiring Concurrent Systemic Antibiotics
657. Impact of Oral Vancomycin Duration on <i>Clostridioides difficile</i> Recurrence in Patients Requiring Concurrent Systemic Antibiotics Open
Background IDSA guidelines for the treatment (TX) of Clostridioides difficile infection (CDI) do not provide specific guidance for total duration of oral vancomycin (VAN) TX in patients requiring prolonged concomitant systemic antibiotics …
View article: 1187. Evaluation of an Antimicrobial Stewardship (AS) Bundle for Uncomplicated Gram-Negative Bloodstream Infections (GN-BSI) in Adults at a Large Academic Health System
1187. Evaluation of an Antimicrobial Stewardship (AS) Bundle for Uncomplicated Gram-Negative Bloodstream Infections (GN-BSI) in Adults at a Large Academic Health System Open
Background AS bundles provide concise steps to clinicians at the point of care to guide antibiotic decision-making. At NYULH GN-BSI bundle was implemented in the electronic health record of the microbiology report. The purpose of this proj…
View article: 2949. Emergency Department (ED) Discharge Antibiotic Prescription Review by Hospital Pharmacists at a Large Academic Medical Center
2949. Emergency Department (ED) Discharge Antibiotic Prescription Review by Hospital Pharmacists at a Large Academic Medical Center Open
Background Direct patient discharge from the Emergency Department (ED) presents an ideal time to promote antimicrobial stewardship (AS). On March 1, 2021 we initiated a pilot program where ED pharmacists conduct a review of discharge antib…
Integrated molecular analysis reveals hypermethylation and overexpression of HOX genes to be poor prognosticators in isocitrate dehydrogenase mutant glioma Open
Background Diffuse gliomas represent over 80% of malignant brain tumors ranging from low-grade to aggressive high-grade lesions. Within isocitrate dehydrogenase (IDH)-mutant gliomas, there is a high variability in survival and a need to mo…
Treatment of Piperacillin-Tazobactam–Nonsusceptible/Ceftriaxone-Susceptible Infections With Carbapenem Versus Carbapenem-Sparing Antimicrobials Open
Background Escherichia coli and Klebsiella pneumoniae with a piperacillin-tazobactam–nonsusceptible/ceftriaxone-susceptible (TZP-NS/CRO-S) phenotype have been increasingly identified, with limited available literature evaluating treatment …
VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system Open
Collateral lethality occurs when loss of a gene/protein renders cancer cells dependent on its remaining paralog. Combining genome-scale CRISPR/Cas9 loss-of-function screens with RNA sequencing in over 900 cancer cell lines, we found that c…
CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies Open
Metastatic castration-resistant prostate cancers (mCRPCs) are treated with therapies that antagonize the androgen receptor (AR). Nearly all patients develop resistance to AR-targeted therapies (ARTs). Our previous work identified CREB5 as …
VRK1 is required in VRK2-methylated cancers of the nervous system Open
Collateral lethality occurs when loss of one paralog renders cancer cells dependent on the remaining paralog. Combining genome scale CRISPR/Cas9 screens coupled with RNA-sequencing in over 900 cancer cell lines, we found that cancers of ne…
CREB5 reprograms nuclear interactions to promote resistance to androgen receptor targeting therapies Open
Metastatic castration resistant prostate cancers (mCRPC) are treated with therapies that antagonize the androgen receptor (AR). Nearly all patients develop resistance to AR-targeted therapies (ART). Our previous work identified CREB5 as an…
p38 MAPK Inhibition Mitigates Hypoxia-Induced AR Signaling in Castration-Resistant Prostate Cancer Open
Background: Aberrant androgen receptor (AR) signaling is a major driver of castration-resistant prostate cancer (CRPC). Tumor hypoxia increases AR signaling and is associated with treatment resistance in prostate cancer. Heat shock protein…
Transcription factor networks of oligodendrogliomas treated with adjuvant radiotherapy or observation inform prognosis Open
Background Recent international sequencing efforts have allowed for the molecular taxonomy of lower-grade gliomas (LGG). We sought to analyze The Cancer Genome Atlas (TCGA, 2015) gene expression datasets on molecularly defined oligodendrog…
Genomic Amplification and Functional Dependency of the Gamma Actin Gene ACTG1 in Uterine Cancer Open
Sarcomere and cytoskeleton genes, or actomyosin genes, regulate cell biology including mechanical stress, cell motility, and cell division. While actomyosin genes are recurrently dysregulated in cancers, their oncogenic roles have not been…
CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer Open
Androgen-receptor (AR) inhibitors, including enzalutamide, are used for treatment of all metastatic castration-resistant prostate cancers (mCRPCs). However, some patients develop resistance or never respond. We find that the transcription …
RTHP-07. TRANSCRIPTION FACTOR NETWORKS OF OLIGODENDROGLIOMAS (IDH-MUTANT AND 1p/19q CODELETED) TREATED WITH ADJUVANT RADIOTHERAPY OR OBSERVATION INFORMS PROGNOSIS Open
Multicentre sequencing efforts have allowed for the molecular characterization of low-grade gliomas (LGG)(The Cancer Genome Atlas (TCGA), 2015). We sought to analyze TCGA gene expression datasets on oligodendrogliomas patients treated with…
Refractory Hypercalcemia in a Jamaican Woman Open
The two common differential diagnoses for hypercalcemia are malignancy and hyperparathyroidism. In this case of a young woman with hypercalcemia refractory to bisphosphonate treatment, Vitamin D and parathyroid hormone releasing peptide (P…
Refractory Hypercalcemia in a Jamaican Woman Open
Summary The two common differential diagnoses for hypercalcemia are malignancy and hyper-parathyroidism. In this case of a young woman with hypercalcemia refractory to bisphosphonate treatment, Vitamin D and parathyroid hormone releasing p…