Jonathan Vöglein
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View article: The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology
The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology Open
BACKGROUND Tau‐derived cerebrospinal fluid (CSF) biomarkers correlate with amyloid‐beta (Aβ) plaques or tau tangles in Alzheimer's disease (AD). This study assessed the effects of long‐term anti‐Aβ antibodies on amyloid plaques, tau tangle…
View article: Patient attitude towards lecanemab: results from a survey within the European Alzheimer’s disease consortium (EADC), the German memory clinic network (DNG) and Austrian memory centers
Patient attitude towards lecanemab: results from a survey within the European Alzheimer’s disease consortium (EADC), the German memory clinic network (DNG) and Austrian memory centers Open
INTRODUCTION Lecanemab approval was long pending in the EU but has now been granted. European patient attitudes towards anti-amyloid therapies are insufficiently assessed and reported. METHODS We conducted an anonymous, multicenter survey …
View article: Ubiquitin–proteasome system in the different stages of dominantly inherited Alzheimer's disease
Ubiquitin–proteasome system in the different stages of dominantly inherited Alzheimer's disease Open
INTRODUCTION This study investigated the role of the ubiquitin–proteasome system (UPS) in dominantly inherited Alzheimer's disease (DIAD) by examining cerebrospinal fluid (CSF) levels of UPS proteins. METHOD The SOMAscan assay was used to …
View article: Correlation of early-phase β-amyloid positron-emission-tomography and neuropsychological testing in patients with Alzheimer’s disease
Correlation of early-phase β-amyloid positron-emission-tomography and neuropsychological testing in patients with Alzheimer’s disease Open
Purpose Clinical staging in individuals with Alzheimer’s disease (AD) typically relies on neuropsychological testing. Recognizing the imperative for an objective measure of clinical AD staging, regional perfusion in early-phase β-amyloid-P…
View article: The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset
The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset Open
We present a comprehensive global analysis of genetic variants associated with autosomal-dominant Alzheimer’s disease (ADAD). A total of 550 variants in the APP, PSEN1 and PSEN2 genes were identified, of which 279 were classified as pathog…
View article: Lewy body pathology in autosomal dominant and sporadic Alzheimer’s disease – neuropathological distribution patterns and associated survival and genetic findings
Lewy body pathology in autosomal dominant and sporadic Alzheimer’s disease – neuropathological distribution patterns and associated survival and genetic findings Open
Background Lewy body pathology (LBP) is common in autosomal dominant (ADAD) or sporadic Alzheimer disease (sAD). LBP seems to be the most frequent co‐pathology in sAD and even in the relatively young ADAD population, where other co‐patholo…
View article: Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease
Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease Open
Disease-modifying therapies for Alzheimer’s disease (AD) are likely to be most beneficial when initiated in the presymptomatic phase. To track the benefit of such interventions, fluid biomarkers are of great importance, with neurofilament …
View article: Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia
Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia Open
We identified multiple clusters of behavioral and neuropsychiatric symptoms in participants with genetic FTD that relate to distinct cerebral atrophy patterns. Their severity depends on time, affected gene, sex, and education. These clinic…
View article: Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer’s Disease
Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer’s Disease Open
This study explored the role of the ubiquitin-proteasome system (UPS) in dominantly inherited Alzheimer’s disease (DIAD) by examining changes in cerebrospinal fluid (CSF) levels of UPS proteins along with disease progression, AD imaging bi…
View article: α‐Synuclein seed amplification assay detects Lewy body co‐pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden
α‐Synuclein seed amplification assay detects Lewy body co‐pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden Open
INTRODUCTION Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer's disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50% of AD and ADAD brains. METHODS Using an α‐synuclein s…
View article: Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging
Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging Open
This research was supported by the Knight Alzheimer Disease Research Center (Knight ADRC, NIH grants P30AG066444, P01AG026276, P01AG003991), Dominantly Inherited Alzheimer Network (DIAN, NIH grants U01AG042791, U19AG03243808, R01AG052550-0…
View article: Measurement properties of the German version of the Cambridge examination for mental disorders of older people with Down syndrome and others with intellectual disabilities (CAMDEX-DS)
Measurement properties of the German version of the Cambridge examination for mental disorders of older people with Down syndrome and others with intellectual disabilities (CAMDEX-DS) Open
Currently, the CAMDEX-DS including the CAMCOG-DS are the outcome assessments for assessing dementia in Down syndrome with the best psychometric properties; however, revision is recommended.
View article: Presenilin‐1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage
Presenilin‐1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage Open
INTRODUCTION Amyloidosis, including cerebral amyloid angiopathy, and markers of small vessel disease (SVD) vary across dominantly inherited Alzheimer's disease (DIAD) presenilin‐1 ( PSEN1) mutation carriers. We investigated how mutation po…
View article: Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease
Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease Open
Background “Brain-predicted age” estimates biological age from complex, nonlinear features in neuroimaging scans. The brain age gap (BAG) between predicted and chronological age is elevated in sporadic Alzheimer disease (AD), but is undere…
View article: Refinement of Neurofilament light Dynamics in CSF and Blood for familial Alzheimer’s Disease
Refinement of Neurofilament light Dynamics in CSF and Blood for familial Alzheimer’s Disease Open
Background Disease‐modifying therapies for Alzheimer’s Disease (AD) are likely most beneficial when initiated in the pre‐symptomatic phase. To track success of such interventions fluid biomarkers became instrumental, with neurofilament lig…
View article: Precision of clinical diagnosis in neurodegenerative diseases: an investigation of 455 autopsied cases
Precision of clinical diagnosis in neurodegenerative diseases: an investigation of 455 autopsied cases Open
Background Accuracy of clinical diagnosis in neurodegenerative diseases is critically important for patient care and study recruitment. We aimed to investigate the precision of clinical diagnosis of various neurodegenerative conditions usi…
View article: Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission
Metabolic network alterations as a supportive biomarker in dementia with Lewy bodies with preserved dopamine transmission Open
View article: <scp>T1</scp> and <scp>FLAIR</scp> signal intensities are related to tau pathology in dominantly inherited Alzheimer disease
<span>T1</span> and <span>FLAIR</span> signal intensities are related to tau pathology in dominantly inherited Alzheimer disease Open
Carriers of mutations responsible for dominantly inherited Alzheimer disease provide a unique opportunity to study potential imaging biomarkers. Biomarkers based on routinely acquired clinical MR images, could supplement the extant invasiv…
View article: Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease Open
View article: Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN)
Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN) Open
View article: Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort
Sex difference in evolution of cognitive decline: studies on mouse model and the Dominantly Inherited Alzheimer Network cohort Open
View article: Cross‐sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle‐aged individuals with a parental history of either autosomal dominant or late‐onset Alzheimer's disease
Cross‐sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle‐aged individuals with a parental history of either autosomal dominant or late‐onset Alzheimer's disease Open
Background Comparisons of late‐onset Alzheimer's disease (LOAD) and autosomal dominant AD (ADAD) are confounded by age. Methods We compared biomarkers from cerebrospinal fluid (CSF), magnetic resonance imaging, and amyloid imaging with Pit…
View article: Symptomatology in 4-repeat tauopathies is associated with data-driven topology of [18F]-PI-2620 tau-PET signal
Symptomatology in 4-repeat tauopathies is associated with data-driven topology of [18F]-PI-2620 tau-PET signal Open
In recent years in vivo visualization of tau deposits has become possible with various PET radiotracers. The tau tracer [18F]PI-2620 proved high affinity both to 3-repeat/4-repeat tau in Alzheimer's disease as well as to 4-repea…
View article: Issue Information
Issue Information Open
View article: Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan
Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan Open
The temporal evolutions and relative orderings of Alzheimer disease biomarkers, including CSF amyloid-β42 (Aβ42), Aβ40, total tau (Tau) and phosphorylated tau181 (pTau181), standardized uptake value ratio (SUVR) from the molecular imaging …
View article: Covariance-based vs. correlation-based functional connectivity dissociates healthy aging from Alzheimer disease
Covariance-based vs. correlation-based functional connectivity dissociates healthy aging from Alzheimer disease Open
View article: Comparative Analysis of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers Measurement by Multiplex SOMAscan Platform and Immunoassay-Based Approach
Comparative Analysis of Alzheimer’s Disease Cerebrospinal Fluid Biomarkers Measurement by Multiplex SOMAscan Platform and Immunoassay-Based Approach Open
Background: The SOMAscan assay has an advantage over immunoassay-based methods because it measures a large number of proteins in a cost-effective manner. However, the performance of this technology compared to the routinely used immunoassa…
View article: Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease
Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease Open
Introduction As knowledge about neurological examination findings in autosomal dominant Alzheimer disease (ADAD) is incomplete, we aimed to determine the frequency and significance of neurological examination findings in ADAD. Methods Freq…
View article: Kardinalbefunde zur Differenzialdiagnose zerebrale Vaskulitis vs. reversibles zerebrales Vasokonstriktionssyndrom
Kardinalbefunde zur Differenzialdiagnose zerebrale Vaskulitis vs. reversibles zerebrales Vasokonstriktionssyndrom Open
View article: Autosomal dominant and sporadic late onset Alzheimer's disease share a common<i>in vivo</i>pathophysiology
Autosomal dominant and sporadic late onset Alzheimer's disease share a common<i>in vivo</i>pathophysiology Open
The extent to which the pathophysiology of autosomal dominant Alzheimer's disease corresponds to the pathophysiology of ‘sporadic’ late onset Alzheimer's disease is unknown, thus limiting the extrapolation of study findings and clinical tr…