Jonathan Vuong
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View article: Challenging the preclinical paradigm: Adverse effects of antiseizure medicines in male rats with drug‐resistant epilepsy
Challenging the preclinical paradigm: Adverse effects of antiseizure medicines in male rats with drug‐resistant epilepsy Open
Background and Purpose Drug‐resistant epilepsy affects 30% of patients who have uncontrolled seizures despite current antiseizure medications (ASMs). Preclinical drug screening often uses acute dosing and evoked seizures, which may not ful…
View article: Temporal relationship between levetiracetam nonadherence and breakthrough seizures in a preclinical model of temporal lobe epilepsy
Temporal relationship between levetiracetam nonadherence and breakthrough seizures in a preclinical model of temporal lobe epilepsy Open
Objective Poor medication adherence remains a concern for individuals managing their epilepsy with antiseizure medicines (ASMs); however, ethical concerns around withholding medication make it impossible to study the causal relationship be…
View article: Perampanel’s forgiveness factor in a variable medication adherence paradigm in a rat model of chronic epilepsy
Perampanel’s forgiveness factor in a variable medication adherence paradigm in a rat model of chronic epilepsy Open
Background:Poor medication adherence contributes to increased morbidity and mortality in patients with epilepsy and may be under-addressed in clinical practice. Ethical concerns make it impossible to study the impact of medication nonadher…