Jonathan Y. Lam
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Comparing High-Flow Nasal Cannula and Non-Invasive Ventilation in Critical Care: Insights from Deep Counterfactual Inference Open
Randomized trials comparing high-flow nasal cannula (HFNC) and non-invasive positive pressure ventilation (NIV) for acute respiratory failure (ARF) offer population-level guidance but often fail to capture individual variability in treatme…
Development, deployment, and continuous monitoring of a machine learning model to predict respiratory failure in critically ill patients Open
Objectives This study describes the development and deployment of a machine learning (ML) model called Vent.io to predict mechanical ventilation (MV). Materials and Methods We trained Vent.io using electronic health record data of adult pa…
Development and validation of a deep learning algorithm for the prediction of serum creatinine in critically ill patients Open
Objectives Serum creatinine (SCr) is the primary biomarker for assessing kidney function; however, it may lag behind true kidney function, especially in instances of acute kidney injury (AKI). The objective of the work is to develop Nephro…
The impact of laboratory data missingness on sepsis diagnosis timeliness Open
Objective To investigate the impact of missing laboratory measurements on sepsis diagnostic delays. Materials and Methods In adult patients admitted to 2 University of California San Diego (UCSD) hospitals from January 1, 2021 to June 30, …
CCDC 2221328: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
CCDC 2221331: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
Intravenous immunoglobulin resistance in Kawasaki disease patients: prediction using clinical data Open
Background About 10–20% of Kawasaki disease (KD) patients are resistant to the initial infusion of intravenous immunoglobin (IVIG). The aim of this study was to assess whether IVIG resistance in KD patients could be predicted using standar…
View article: Multicenter Validation of a Machine Learning Algorithm for Diagnosing Pediatric Patients with Multisystem Inflammatory Syndrome and Kawasaki Disease
Multicenter Validation of a Machine Learning Algorithm for Diagnosing Pediatric Patients with Multisystem Inflammatory Syndrome and Kawasaki Disease Open
Background Multisystem inflammatory syndrome in children (MIS-C) is a novel disease identified during the COVID-19 pandemic characterized by systemic inflammation following SARS-CoV-2 infection. Delays in diagnosing MIS-C may lead to more …
Cryopreservation and post-thaw characterization of dissociated human islet cells Open
The objective of this study is to optimize the cryopreservation of dissociated islet cells and obtain functional cells that can be used in single-cell transcriptome studies on the pathology and treatment of diabetes. Using an iterative gra…
Implementation of KIDMATCH: A Clinical Decision Support Tool for Diagnosing Pediatric Patients with Multisystem Inflammatory Syndrome and Kawasaki Disease. Open
Multisystem inflammatory syndrome in children (MIS-C) is a novel disease identified during the COVID-19 pandemic that may lead to cardiac dysfunction or death in pediatric patients. Early detection of MIS-C remains a challenge given the la…
SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells Open
The physiological functions of many vital tissues and organs continue to mature after birth, but the genetic mechanisms governing this postnatal maturation remain an unsolved mystery. Human pancreatic β cells produce and secrete insulin in…
SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells Open
The physiological functions of many vital tissues and organs continue to mature after birth, but the genetic mechanisms governing this postnatal maturation remain an unsolved mystery. Human pancreatic β-cells produce and secrete insulin in…
Molecular and genetic regulation of pig pancreatic islet cell development Open
Reliance on rodents for understanding pancreatic genetics, development and islet function could limit progress in developing interventions for human diseases such as diabetes mellitus. Similarities of pancreas morphology and function sugge…
Molecular and genetic regulation of pig pancreatic islet cell development Open
Reliance on rodents for understanding pancreatic genetics, development and islet function could limit progress in developing interventions for human diseases like diabetes mellitus. Similarities of pancreas morphology and function suggest …