Jonathan Yeow
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View article: Photo-PISA Driven <i>In Situ</i> Encapsulation of Nanocluster-Based Sensors within Stimuli-Responsive Polymersomes for AND Logic Gate Sensing
Photo-PISA Driven <i>In Situ</i> Encapsulation of Nanocluster-Based Sensors within Stimuli-Responsive Polymersomes for AND Logic Gate Sensing Open
Colorimetric sensing is a widely utilized analytical technique due to its simplicity, accessibility, rapid response, and broad applicability in medical diagnostics. However, improving the sensitivity and specificity of these assays remains…
View article: Wavelength-Dependent Feedback Behaviour in Light-Gated Polymersome Nanoreactors
Wavelength-Dependent Feedback Behaviour in Light-Gated Polymersome Nanoreactors Open
Biological systems integrate multiple feedback processes to regulate their adaptation to evolving stimuli with high specificity. Inspired by wavelength-selective feedback processes in visual signaling, we present a synthetic nanoreactor sy…
View article: The interplay between endothelial glycocalyx maturity and both the toxicity and intracellular uptake of charged nanoparticles
The interplay between endothelial glycocalyx maturity and both the toxicity and intracellular uptake of charged nanoparticles Open
Nanoparticles are widely studied for delivering treatments to target tissues, but few have reached clinical use. Most nanoparticles encounter blood vessels on their way to target tissues. The inner surface of these vessels is lined with en…
View article: Nanoscale Biodegradable Printing for Designed Tuneability of Vaccine Delivery Kinetics
Nanoscale Biodegradable Printing for Designed Tuneability of Vaccine Delivery Kinetics Open
Two‐photon polymerization (2PP) 3D printing enables top–down biomaterial synthesis with nanoscale spatial resolution for de novo design of monodisperse injectable drug delivery systems. Spatiotemporal Controlled Release Inks of Biocompatib…
View article: Unlocking Intracellular Protein Delivery by Harnessing Polymersomes Synthesized at Microliter Volumes using Photo‐PISA
Unlocking Intracellular Protein Delivery by Harnessing Polymersomes Synthesized at Microliter Volumes using Photo‐PISA Open
Efficient delivery of therapeutic proteins and vaccine antigens to intracellular targets is challenging due to generally poor cell membrane permeation and endolysosomal entrapment causing degradation. Herein, these challenges are addressed…
View article: “Nanoscale biodegradable printing for designed tuneability of vaccine delivery kinetics”
“Nanoscale biodegradable printing for designed tuneability of vaccine delivery kinetics” Open
Two photon polymerization (2PP) 3D printing enables top-down biomaterial synthesis with nanoscale spatial resolution for de novo design of monodisperse injectable drug delivery systems. To address the limitations of current 2PP resins, we …
View article: The level of endothelial glycocalyx maturity modulates interactions with charged nanomaterials
The level of endothelial glycocalyx maturity modulates interactions with charged nanomaterials Open
Nanomaterials have been extensively investigated for their potential in delivering therapeutics to target tissues, but few have advanced to clinical application. The luminal surface of endothelial cells that line blood vessels are covered …
View article: Thermally Robust Solvent-Free Liquid Polyplexes for Heat-Shock Protection and Long-Term Room Temperature Storage of Therapeutic Nucleic Acids
Thermally Robust Solvent-Free Liquid Polyplexes for Heat-Shock Protection and Long-Term Room Temperature Storage of Therapeutic Nucleic Acids Open
Nucleic acid therapeutics have attracted recent attention as promising preventative solutions for a broad range of diseases. Nonviral delivery vectors, such as cationic polymers, improve the cellular uptake of nucleic acids without sufferi…
View article: 4D Multimaterial Printing of Soft Actuators with Spatial and Temporal Control
4D Multimaterial Printing of Soft Actuators with Spatial and Temporal Control Open
Soft actuators (SAs) are devices which can interact with delicate objects in a manner not achievable with traditional robotics. While it is possible to design a SA whose actuation is triggered via an external stimulus, the use of a single …
View article: A fully automated platform for photoinitiated RAFT polymerization
A fully automated platform for photoinitiated RAFT polymerization Open
The use of robotic instrumentation and Python scripts allows for fully automated and robust combinatorial polymer synthesis.
View article: Differences in Human Plasma Protein Interactions between Various Polymersomes and Stealth Liposomes as Observed by Fluorescence Correlation Spectroscopy
Differences in Human Plasma Protein Interactions between Various Polymersomes and Stealth Liposomes as Observed by Fluorescence Correlation Spectroscopy Open
A significant factor hindering the clinical translation of polymersomes as vesicular nanocarriers is the limited availability of comparative studies detailing their interaction with blood plasma proteins compared to liposomes. Here, polyme…
View article: Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors
Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors Open
The circadian rhythm generates out-of-equilibrium metabolite oscillations that are controlled by feedback loops under light/dark cycles. Here we describe a non-equilibrium nanosystem comprising a binary population of enzyme-containing poly…
View article: Microliter Scale Synthesis of Luciferase‐Encapsulated Polymersomes as Artificial Organelles for Optogenetic Modulation of Cardiomyocyte Beating
Microliter Scale Synthesis of Luciferase‐Encapsulated Polymersomes as Artificial Organelles for Optogenetic Modulation of Cardiomyocyte Beating Open
Constructing artificial systems that effectively replace or supplement natural biological machinery within cells is one of the fundamental challenges underpinning bioengineering. At the sub‐cellular scale, artificial organelles (AOs) have …
View article: Potent Virustatic Polymer–Lipid Nanomimics Block Viral Entry and Inhibit Malaria Parasites In Vivo
Potent Virustatic Polymer–Lipid Nanomimics Block Viral Entry and Inhibit Malaria Parasites In Vivo Open
Infectious diseases continue to pose a substantial burden on global populations, requiring innovative broad-spectrum prophylactic and treatment alternatives. Here, we have designed modular synthetic polymer nanoparticles that mimic functio…
View article: Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors
Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors Open
The circadian rhythm generates out-of-equilibrium metabolite oscillations controlled by feedback loops under light/dark cycles. Here we describe a non-equilibrium nanosystem comprising a binary population of enzyme-containing polymersomes …
View article: Polymer formulated self-amplifying RNA vaccine is partially protective against influenza virus infection in ferrets
Polymer formulated self-amplifying RNA vaccine is partially protective against influenza virus infection in ferrets Open
COVID-19 has demonstrated the power of RNA vaccines as part of a pandemic response toolkit. Another virus with pandemic potential is influenza. Further development of RNA vaccines in advance of a future influenza pandemic will save time an…
View article: Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer
Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer Open
Self-amplifying RNA (saRNA) vaccines are highly advantageous, as they result in enhanced protein expression compared to mRNA (mRNA), thus minimizing the required dose. However, previous delivery strategies were optimized for siRNA or mRNA …
View article: An improved synthesis of poly(amidoamine)s for complexation with self-amplifying RNA and effective transfection
An improved synthesis of poly(amidoamine)s for complexation with self-amplifying RNA and effective transfection Open
Aza-Michael addition to synthesise poly(amidoamines) was optimised to minimise appearance of bimodal molecular weight distributions caused by a radical-branching side-reaction. This significantly improved cellular delivery of a model self-…
View article: Emerging Trends in Polymerization-Induced Self-Assembly
Emerging Trends in Polymerization-Induced Self-Assembly Open
In this Perspective, we summarize recent progress in polymerization-induced self-assembly (PISA) for the rational synthesis of block copolymer nanoparticles with various morphologies. Much of the PISA literature has been based on thermally…
View article: Visible Light-Mediated Polymerization-Induced Self-Assembly Using Continuous Flow Reactors
Visible Light-Mediated Polymerization-Induced Self-Assembly Using Continuous Flow Reactors Open
We present the synthesis of polymeric nano-particles of targeted morphology in a continuous process via visible light-mediated aqueous RAFT polymerization-induced self-assembly (PISA). A trithiocarbonate-derived poly-(ethylene glycol) (PEG…
View article: An Oxygen‐Tolerant PET‐RAFT Polymerization for Screening Structure–Activity Relationships
An Oxygen‐Tolerant PET‐RAFT Polymerization for Screening Structure–Activity Relationships Open
The complexity of polymer–protein interactions makes rational design of the best polymer architecture for any given biointerface extremely challenging, and the high throughput synthesis and screening of polymers has emerged as an attractiv…
View article: Up in the air: oxygen tolerance in controlled/living radical polymerisation
Up in the air: oxygen tolerance in controlled/living radical polymerisation Open
In this review, we outline the current strategies for achieving oxygen tolerance in controlled/living radical polymerisation.
View article: Correction: The effects of polymer topology and chain length on the antimicrobial activity and hemocompatibility of amphiphilic ternary copolymers
Correction: The effects of polymer topology and chain length on the antimicrobial activity and hemocompatibility of amphiphilic ternary copolymers Open
Correction for ‘The effects of polymer topology and chain length on the antimicrobial activity and hemocompatibility of amphiphilic ternary copolymers’ by Rashin Namivandi-Zangeneh, et al., Polym. Chem., 2017, DOI: 10.1039/c7py01069a.
View article: The effects of polymer topology and chain length on the antimicrobial activity and hemocompatibility of amphiphilic ternary copolymers
The effects of polymer topology and chain length on the antimicrobial activity and hemocompatibility of amphiphilic ternary copolymers Open
Hyperbranched random copolymers that consist of ethylhexyl hydrophobic groups have the best selectivity compared to linear random and block copolymers.
View article: Photoinitiated Polymerization‐Induced Self‐Assembly (Photo‐PISA): New Insights and Opportunities
Photoinitiated Polymerization‐Induced Self‐Assembly (Photo‐PISA): New Insights and Opportunities Open
The polymerization‐induced self‐assembly (PISA) process is a useful synthetic tool for the efficient synthesis of polymeric nanoparticles of different morphologies. Recently, studies on visible light initiated PISA processes have offered a…
View article: Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst
Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst Open
Presented herein is a protocol for the facile synthesis of worm-like micelles by visible light mediated dispersion polymerization. This approach begins with the synthesis of a hydrophilic poly(oligo(ethylene glycol) methyl ether methacryla…
View article: Macromol. Rapid Commun. 11/2016
Macromol. Rapid Commun. 11/2016 Open
Back Cover: Polymers featuring photoresponsive groups have been exploited as promising drug delivery systems. Light as spatially and temporally controllable external stimulus can be readily tuned and focused to trigger changes in the struc…