Jonathon Heath
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View article: Pilot study of peripheral internal jugular venous catheters on a hospitalist‐run medicine procedure service
Pilot study of peripheral internal jugular venous catheters on a hospitalist‐run medicine procedure service Open
Providers caring for hospitalized patients with difficult intravenous access (DIVA) frequently use central venous catheters (CVCs). One potential alternative is a peripheral internal jugular (PIJ) catheter, which is less traumatic to place…
View article: PS1518 GENOME EDITING OF HBG1/2 PROMOTER LEADS TO ROBUST HBF INDUCTION IN VIVO, WHILE EDITING OF BCL11A ERYTHROID ENHANCER RESULTS IN ERYTHROID DEFECTS
PS1518 GENOME EDITING OF HBG1/2 PROMOTER LEADS TO ROBUST HBF INDUCTION IN VIVO, WHILE EDITING OF BCL11A ERYTHROID ENHANCER RESULTS IN ERYTHROID DEFECTS Open
Background: Induction of fetal hemoglobin (HbF) is an attractive approach to ameliorate disease symptoms in beta hemoglobinopathies. Gene editing by zinc finger or CRISPR‐Cas nucleases to disrupt BCL11A expression, a known mediator of feta…
View article: Digital image‐assisted quantitative nuclear analysis improves diagnostic accuracy of thyroid fine‐needle aspiration cytology
Digital image‐assisted quantitative nuclear analysis improves diagnostic accuracy of thyroid fine‐needle aspiration cytology Open
Background Thyroid fine‐needle aspiration (FNA) plays a key role in triaging thyroid nodules. Yet many cases are assigned to indeterminate categories. The new category “noninvasive follicular thyroid neoplasm with papillary‐like features” …
View article: Neuroendocrine cell proliferations in lungs explanted for fibrotic interstitial lung disease and emphysema
Neuroendocrine cell proliferations in lungs explanted for fibrotic interstitial lung disease and emphysema Open
View article: Mice with Inflammatory Bowel Disease are Susceptible to<i>Clostridium difficile</i>Infection With Severe Disease Outcomes
Mice with Inflammatory Bowel Disease are Susceptible to<i>Clostridium difficile</i>Infection With Severe Disease Outcomes Open
We, for the first time, demonstrate in an animal model that mice with dextran sulfate sodium induced-inflammatory bowel disease are significantly more susceptible to C. difficile infection, and that the bacterial infection led to more seve…
View article: <i>Slc10a2</i> -null mice uncover colon cancer-promoting actions of endogenous fecal bile acids
<i>Slc10a2</i> -null mice uncover colon cancer-promoting actions of endogenous fecal bile acids Open
Although epidemiological evidence in humans and bile acid feeding studies in rodents implicate bile acids as tumor promoters, the role of endogenous bile acids in colon carcinogenesis remains unclear. In this study, we exploited mice defic…