Jong Bin Bae
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View article: Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia
Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia Open
View article: Procedural Knowledge in Pretraining Drives Reasoning in Large Language Models
Procedural Knowledge in Pretraining Drives Reasoning in Large Language Models Open
The capabilities and limitations of Large Language Models have been sketched out in great detail in recent years, providing an intriguing yet conflicting picture. On the one hand, LLMs demonstrate a general ability to solve problems. On th…
View article: White matter microstructural integrity as a key to effective propagation of gamma entrainment in humans
White matter microstructural integrity as a key to effective propagation of gamma entrainment in humans Open
View article: Construction and validation of a brain magnetic resonance imaging template for normal older Koreans
Construction and validation of a brain magnetic resonance imaging template for normal older Koreans Open
Background Spatial normalization to a standardized brain template is a crucial step in magnetic resonance imaging (MRI) studies. Brain templates made from sufficient sample size have low brain variability, improving the accuracy of spatial…
View article: The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose–response meta-analysis
The influence of n-3 polyunsaturated fatty acids on cognitive function in individuals without dementia: a systematic review and dose–response meta-analysis Open
View article: A Case-Control Clinical Trial on a Deep Learning-Based Classification System for Diagnosis of Amyloid-Positive Alzheimer’s Disease
A Case-Control Clinical Trial on a Deep Learning-Based Classification System for Diagnosis of Amyloid-Positive Alzheimer’s Disease Open
Objective A deep learning-based classification system (DLCS) which uses structural brain magnetic resonance imaging (MRI) to diagnose Alzheimer’s disease (AD) was developed in a previous recent study. Here, we evaluate its performance by c…
View article: Association of estimated white matter hyperintensity age with cognition in hypertensive elderly
Association of estimated white matter hyperintensity age with cognition in hypertensive elderly Open
Background Hypertension is associated with white matter hyperintensity (WMH) and cognitive impairment. Further, WMH is associated with cognitive impairment including executive, attention and visuospatial functions. The aim of this study wa…
View article: What is the impact of one’s chronic illness on his or her spouse’s future chronic illness: a community-based prospective cohort study
What is the impact of one’s chronic illness on his or her spouse’s future chronic illness: a community-based prospective cohort study Open
Background Integrating a joint approach to chronic disease management within the context of a couple has immense potential as a valuable strategy for both prevention and treatment. Although spousal concordance has been reported in specific…
View article: A longitudinal resource for population neuroscience of school-age children and adolescents in China
A longitudinal resource for population neuroscience of school-age children and adolescents in China Open
View article: A Preliminary Study on the Potential Protective Role of the Antioxidative Stress Markers of Cognitive Impairment: Glutathione and Glutathione Reductase
A Preliminary Study on the Potential Protective Role of the Antioxidative Stress Markers of Cognitive Impairment: Glutathione and Glutathione Reductase Open
: The higher the GR, the lower the prevalence of Alzheimer's dementia and incidence of cognitive impairment and the higher the cognitive test scores. Therefore, GR is a potential protective biomarker against Alzheimer's dementia and cognit…
View article: Development of a Gait Feature–Based Model for Classifying Cognitive Disorders Using a Single Wearable Inertial Sensor
Development of a Gait Feature–Based Model for Classifying Cognitive Disorders Using a Single Wearable Inertial Sensor Open
This study provides Class III evidence that gait analysis can accurately distinguish older adults with CDs from healthy controls.
View article: Parental history of dementia and the risk of dementia: A cross‐sectional analysis of a global collaborative study
Parental history of dementia and the risk of dementia: A cross‐sectional analysis of a global collaborative study Open
Background Parental history of dementia appears to increase the risk of dementia, but there have been inconsistent results. We aimed to investigate whether the association between parental history of dementia and the risk of dementia are d…
View article: Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea
Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea Open
Importance Although couples may share many risk factors for depressive disorders in their lifetime, whether these factors mediate the shared risk of depressive disorders has rarely been investigated. Objectives To identify the shared risk …
View article: Association of estimated white matter hyperintensity age with cognition in elderly with controlled hypertension
Association of estimated white matter hyperintensity age with cognition in elderly with controlled hypertension Open
View article: Deep learning-based diagnosis of Alzheimer’s disease using brain magnetic resonance images: an empirical study
Deep learning-based diagnosis of Alzheimer’s disease using brain magnetic resonance images: an empirical study Open
View article: Clinical Data Interchange Standards in Clinical Trials on Alzheimer’s Disease
Clinical Data Interchange Standards in Clinical Trials on Alzheimer’s Disease Open
Objective The Clinical Data Interchange Standards Consortium (CDISC) proposed outcome measures for clinical trials on Alzheimer’s disease (AD) in the Therapeutic Area User Guide for AD (TAUG-AD). To investigate how well the clinical trials…
View article: Development of a gait speed estimation model for healthy older adults using a single inertial measurement unit
Development of a gait speed estimation model for healthy older adults using a single inertial measurement unit Open
Although gait speed changes are associated with various geriatric conditions, standard gait analysis systems, such as laboratory-based motion capture systems or instrumented walkways, are too expensive, spatially limited, and difficult to …
View article: Publisher Correction: Brain charts for the human lifespan
Publisher Correction: Brain charts for the human lifespan Open
In the version of this article initially published, there were errors in the affiliations for K. Im (missing affiliation, Division of Newborn Medicine and Neuroradiology, Fetal Neonatal Neuroimaging and Developmental Science Center, Boston…
View article: Optimal flickering light stimulation for entraining gamma rhythms in older adults
Optimal flickering light stimulation for entraining gamma rhythms in older adults Open
View article: Association of Low Emotional and Tangible Support With Risk of Dementia Among Adults 60 Years and Older in South Korea
Association of Low Emotional and Tangible Support With Risk of Dementia Among Adults 60 Years and Older in South Korea Open
Importance The association between social support and dementia risk has been debated. Most previous prospective studies have not differentiated the subtypes of social support. Objective To examine whether the association between social sup…
View article: Altered resting state brain metabolic connectivity in dementia with Lewy bodies
Altered resting state brain metabolic connectivity in dementia with Lewy bodies Open
Although dementia with Lewy bodies (DLB) have Parkinsonism in common with Parkinson's disease (PD) or PD dementia (PDD), they have different neuropathologies that underlie Parkinsonism. Altered brain functional connectivity that may corres…
View article: Association Between Retinal Layer Thickness and Cognitive Decline in Older Adults
Association Between Retinal Layer Thickness and Cognitive Decline in Older Adults Open
In this study, macular RNFL thickness could be used as a prognostic biomarker of long-term cognitive decline in adults 60 years or older. However, to confirm these results, further large-scale population-based studies should be performed.
View article: Association between serum free hemoglobin level and cerebral white matter hyperintensity volume in older adults
Association between serum free hemoglobin level and cerebral white matter hyperintensity volume in older adults Open
The association between serum free hemoglobin (sfHb) level and white matter hyperintensity (WMH) volume is controversial. This study is to examine this association considering nonlinearity, sex dimorphism, and WMH type. We enrolled 704 old…
View article: Association of Estimated White Matter Hyperintensity Age with Cognition in Elderly with Controlled Hypertension
Association of Estimated White Matter Hyperintensity Age with Cognition in Elderly with Controlled Hypertension Open
View article: Exploration of Cognitive Outcomes and Risk Factors for Cognitive Decline Shared by Couples
Exploration of Cognitive Outcomes and Risk Factors for Cognitive Decline Shared by Couples Open
These findings suggest that the risk factors shared within couples may mediate approximately three-quarters of the spousal risk of cognitive disorders. Identification of and intervention in the shared risk factors of dementia within couple…
View article: The impact of the COVID-19 pandemic on depression in community-dwelling older adults: a prospective cohort study
The impact of the COVID-19 pandemic on depression in community-dwelling older adults: a prospective cohort study Open
Background There are growing concerns about the impact of the COVID-19 pandemic on the mental health of older adults. We examined the effect of the pandemic on the risk of depression in older adults. Methods We analyzed data from the prosp…
View article: The relationship between alcohol use and dementia in adults aged over 60 years: A combined analysis of prospective, individual-participant data from 15 international studies
The relationship between alcohol use and dementia in adults aged over 60 years: A combined analysis of prospective, individual-participant data from 15 international studies Open
Objective: To synthesise international findings on the alcohol-dementia relationship and provide a cross-national comparison of the alcohol-dementia relationship with critical evidence for the relationship between alcohol use and dementia …
View article: Association of Thyroid Dysfunction With Cognitive Function
Association of Thyroid Dysfunction With Cognitive Function Open
In this individual participant data analysis of more than 74 000 adults, subclinical hypothyroidism and hyperthyroidism were not associated with cognitive function, cognitive decline, or incident dementia. No rigorous conclusions can be dr…
View article: A case-control clinical trial on the diagnostic performance for Alzheimer’s Disease of a deep learning-based classification system using brain magnetic resonance imaging
A case-control clinical trial on the diagnostic performance for Alzheimer’s Disease of a deep learning-based classification system using brain magnetic resonance imaging Open
Objective To investigate diagnostic performance of a deep learning-based classification system using structural brain MRI (DLCS) for Alzheimer’s disease (AD). Methods A single-center, case-control clinical trial was conducted. T1-weighted …
View article: Reliability and Validity of Alzheimer's Disease Screening With a Semi-automated Smartphone Application Using Verbal Fluency
Reliability and Validity of Alzheimer's Disease Screening With a Semi-automated Smartphone Application Using Verbal Fluency Open
Introduction: This study aimed to examine the reliability and validity of Alzheimer's disease (AD) screening with a self-administered categorical verbal fluency test using a semi-automated Android application (app; tCVFT). Furthermore, its…