Jong Eun Lee
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View article: The Role of Agmatine in Modulating Autophagy Under Neuroinflammatory Conditions Induced by Metabolic Alteration in Mouse Brain
The Role of Agmatine in Modulating Autophagy Under Neuroinflammatory Conditions Induced by Metabolic Alteration in Mouse Brain Open
Changes in microglia, a specialized population of glial cells found in the central nervous system (CNS), is often associated with hyperglycemic conditions. It has been reported that exogenous administration of agmatine (agm) has neuroprote…
View article: Highly accurate Korean draft genomes reveal structural variation highlighting human telomere evolution
Highly accurate Korean draft genomes reveal structural variation highlighting human telomere evolution Open
Given the presence of highly repetitive genomic regions such as subtelomeric regions, understanding human genomic evolution remains challenging. Recently, long-read sequencing technology has facilitated the identification of complex geneti…
Single-cell RNA sequencing reveals transcriptional changes in circulating immune cells from patients with severe asthma induced by biologics Open
Patients with severe eosinophilic asthma often require systemic medication, including corticosteroids and anti-type 2 (T2) cytokine biologics, to control the disease. While anti-IL5 and anti-IL4Rα antibodies suppress the effects of IL-4, I…
Reconsidering Neurogenetic Indication in the Human Brain: Broad Expression of Doublecortin Transcript in the Hippocampal and Cortical Cell Populations Open
Introduction: Neurogenesis in the adult brain may play an important role in memory and cognition; however, knowledge of neurogenic markers in the human brain remains limited. We compared the single-nucleus transcriptome of the hippocampus …
View article: Minimal Access vs Conventional Nipple-Sparing Mastectomy
Minimal Access vs Conventional Nipple-Sparing Mastectomy Open
Importance While nipple-sparing mastectomy (NSM) for breast cancer was only performed using the open method in the past, its frequency using endoscopic and robotic surgical instruments has been increasing rapidly. However, there are limite…
Development of health promotion program for frail older adults based on the intervention mapping Open
The effectiveness of frailty intervention programs for older adults in Korean communities has been inconsistent, posing challenges for public health nurses (PHNs). This study aims to develop an evidence-based intervention using the Interve…
Identification of the endangered species Haplotropis brunneriana (Insecta: Orthoptera) from South Korea using exuviae Open
Most Pamphagidae species are at risk of being endangered due to their flightlessness, low mobility, and small habitat range. For the same reason, Haplotropis brunneriana (Orthoptera: Pamphagidae) has been designated an endangered species i…
Reconsidering neurogenetic indication in the human brain: Broad expression of doublecortin transcript in hippocampal and cortical cell populations Open
Adult neurogenesis may help overcome Alzheimer’s disease; however, knowledge concerning neurogenic markers in the human brain remains limited. Herein, we compared the hippocampal single-nucleus transcriptome to other cortical regions to ve…
Comparison of different group-level templates in gradient-based multimodal connectivity analysis Open
The study of large-scale brain connectivity is increasingly adopting unsupervised approaches that derive low-dimensional spatial representations from high-dimensional connectomes, referred to as gradient analysis. When translating this app…
View article: SGLT2 and DPP4 inhibitors improve Alzheimer’s disease‐like pathology and cognitive function through distinct mechanisms in T2D‐AD mouse model
SGLT2 and DPP4 inhibitors improve Alzheimer’s disease‐like pathology and cognitive function through distinct mechanisms in T2D‐AD mouse model Open
Background There are common mechanisms between Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2D), such as insulin resistance. As insulin signaling has important roles in regulation of neuronal functions in the brain, the hypothes…
MRI‐Compatible, Transparent PEDOT:PSS Neural Implants for the Alleviation of Neuropathic Pain with Motor Cortex Stimulation Open
Simultaneous monitoring of electrophysiology and magnetic resonance imaging (MRI) could guide the innovative diagnosis and treatment of various neurodegenerative diseases that are previously impossible. However, this technique is difficult…
View article: SGLT2 and DPP4 inhibitors improve Alzheimer’s disease–like pathology and cognitive function through distinct mechanisms in a T2D–AD mouse model
SGLT2 and DPP4 inhibitors improve Alzheimer’s disease–like pathology and cognitive function through distinct mechanisms in a T2D–AD mouse model Open
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2D) share common features, including insulin resistance. Brain insulin resistance has been implicated as a key factor in the pathogenesis of AD. Recent studies have demonstrated that …
FLT4 as a marker for predicting prognostic risk of refractory acute myeloid leukemia Open
Treating patients with refractory acute myeloid leukemia (AML) remains challenging. Currently there is no effective treatment for refractory AML. Increasing evidence has demonstrated that refractory/relapsed AML is associated with leukemic…
Analysis of antibiotic resistance gene cassettes in a newly identified Salmonella enterica serovar Gallinarum strain in Korea Open
Antimicrobial resistant pathogens are a global health threat driven by the indiscriminate use of antimicrobials. Antimicrobial resistance can be acquired by resistance genes encoded by mobile genetic elements. In this study, we identified …
Hyperpolarized [1-<sup>13</sup>C]pyruvate Magnetic Resonance Spectroscopy Shows That Agmatine Increased Lactate Production in the Brain of Type 2 Diabetic Mice Open
Agmatine influences the NADH/NAD+ redox state in the brains of T2DM mice, which may be connected with enhanced cognitive performance and increased conversion of HP [1-13C]pyruvate to HP [1-13C]lactate.
Neural Stem Cells Overexpressing Arginine Decarboxylase Improve Functional Recovery from Spinal Cord Injury in a Mouse Model Open
Current therapeutic strategies for spinal cord injury (SCI) cannot fully facilitate neural regeneration or improve function. Arginine decarboxylase (ADC) synthesizes agmatine, an endogenous primary amine with neuroprotective effects. Trans…
View article: Unbound IRF2 to IRF2BP2 mediates KLF4 signaling leading to anti-inflammatory phenotype of microglia
Unbound IRF2 to IRF2BP2 mediates KLF4 signaling leading to anti-inflammatory phenotype of microglia Open
Background Following central nervous system (CNS) injury, the investigation for neuroinflammation is vital because of its pleiotropic role in both acute injury and long-term recovery. Agmatine (Agm) is well known for its neuroprotective ef…
Comparison of Wound Closure Using Acellular Dermal Matrix With Primary Wound Closure After Breast Conserving Surgery in Breast Cancer Patients Open
Purpose: As breast-conserving surgery has become a standard treatment for patients with breast cancer, several approaches have been devised to achieve desirable cosmetic results, including a method using a patient’s own tissues or organs o…
View article: CCR4 and CCR5 Involvement in Monocyte-Derived Macrophage Migration in Neuroinflammation
CCR4 and CCR5 Involvement in Monocyte-Derived Macrophage Migration in Neuroinflammation Open
Microglia, resident macrophages in the brain, play major roles in neuroinflammation after an acute many neurological diseases, including stroke. Our recent animal stroke model showed that interleukin (IL)-4 and IL-13 released by microglia …
Clinical Significance of Peritumoral Adipose Tissue PET/CT Imaging Features for Predicting Axillary Lymph Node Metastasis in Patients with Breast Cancer Open
We investigated whether textural parameters of peritumoral breast adipose tissue (AT) based on F-18 fluorodeoxyglucose (FDG) PET/CT could predict axillary lymph node metastasis in patients with breast cancer. A total of 326 breast cancer p…