Jong Hoon Ryu
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View article: Effects of an Herbal Medicinal Product Composed of Three Herbal Materials on Lipopolysaccharide-induced Depression-like Behaviors in Mice
Effects of an Herbal Medicinal Product Composed of Three Herbal Materials on Lipopolysaccharide-induced Depression-like Behaviors in Mice Open
An herbal medicinal product consisting of three kinds of herbal materials, Prunella vulgaris L. (Lamiaceae), Clematis chinensis Osbeck (Ranunculaceae) and Trichosanthes kirilowii Max. (Cucurbitaceae) has been prescribed in the clinic for t…
View article: Effects of Icariin and Its Metabolites on GPCR Regulation and MK-801-Induced Schizophrenia-Like Behaviors in Mice
Effects of Icariin and Its Metabolites on GPCR Regulation and MK-801-Induced Schizophrenia-Like Behaviors in Mice Open
Icariin, a major bioactive compound found in the Epimedium genus, has been reported to exert protective effects against neurodegenerative disorders. In the current study, we aimed to investigate the regulatory effect of icariin and its act…
View article: Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice
Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice Open
Haloperidol, one of the representative typical antipsychotics, is on the market for schizophrenia but shows severe adverse effects such as extrapyramidal symptoms (EPS) or cognitive impairments. Oleanolic acid (OA) is known to be effective…
View article: Synthesis and Biological Evaluation of O6-Aminoalkyl-Hispidol Analogs as Multifunctional Monoamine Oxidase-B Inhibitors towards Management of Neurodegenerative Diseases
Synthesis and Biological Evaluation of O6-Aminoalkyl-Hispidol Analogs as Multifunctional Monoamine Oxidase-B Inhibitors towards Management of Neurodegenerative Diseases Open
Oxidative catabolism of monoamine neurotransmitters by monoamine oxidases (MAOs) produces reactive oxygen species (ROS), which contributes to neuronal cells’ death and also lowers monoamine neurotransmitter levels. In addition, acetylcholi…
View article: Review of: "Whole-brain in vivo base editing reverses autistic-like behaviors in mice"
Review of: "Whole-brain in vivo base editing reverses autistic-like behaviors in mice" Open
Potential competing interests: The author(s)
View article: Role of extracellular signal-regulated kinase in rubrofusarin-enhanced cognitive functions and neurite outgrowth
Role of extracellular signal-regulated kinase in rubrofusarin-enhanced cognitive functions and neurite outgrowth Open
Memory-enhancing agents have long been required for various reasons such as for obtaining a good score in a test in the young and for retaining memory in the aged. Although many studies have found that several natural products may be good …
View article: Additional file 2 of The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice
Additional file 2 of The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice Open
Additional file 2: Table S1. Statistical analysis of figures.
View article: In Vitro and In Silico Characterization of G-Protein Coupled Receptor (GPCR) Targets of Phlorofucofuroeckol-A and Dieckol
In Vitro and In Silico Characterization of G-Protein Coupled Receptor (GPCR) Targets of Phlorofucofuroeckol-A and Dieckol Open
Phlorotannins are polyphenolic compounds in marine alga, especially the brown algae. Among numerous phlorotannins, dieckol and phlorofucofuroeckol-A (PFF-A) are the major ones and despite a wider biological activity profile, knowledge of t…
View article: Neuroprotective and anti-neuroinflammatory effects of ethanolic extract from leaves and stems of Aster glehni
Neuroprotective and anti-neuroinflammatory effects of ethanolic extract from leaves and stems of Aster glehni Open
Aster glehni Fr. Schm. has been reported ameliorating effects on cognitive dysfunction. However, the molecular mechanisms underlying neurodegenerative diseases such as Alzheimer’s disease (AD) are poorly understood. Herein, we examined whe…
View article: REDD1 Is Involved in Amyloid β-Induced Synaptic Dysfunction and Memory Impairment
REDD1 Is Involved in Amyloid β-Induced Synaptic Dysfunction and Memory Impairment Open
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by neurological dysfunction, including memory impairment, attributed to the accumulation of amyloid β (Aβ) in the brain. Although several studies reported possible mecha…
View article: Rubrofusarin Attenuates Chronic Restraint Stress-Induced Depressive Symptoms
Rubrofusarin Attenuates Chronic Restraint Stress-Induced Depressive Symptoms Open
The aim of this study was to examine whether rubrofusarin, an active ingredient of the Cassia species, has an antidepressive effect in chronic restraint stress (CRS) mouse model. Although acute treatment using rubrofusarin failed, chronic …
View article: The effect of maslinic acid on cognitive dysfunction induced by cholinergic blockade in mice
The effect of maslinic acid on cognitive dysfunction induced by cholinergic blockade in mice Open
Background and Purpose Alzheimer's disease (AD) is the most prevalent disease associated with cognitive dysfunction. Current AD therapeutic agents have several gastrointestinal or psychological adverse effects and therefore, novel therapeu…
View article: A botanical drug composed of three herbal materials attenuates the sensorimotor gating deficit and cognitive impairment induced by MK-801 in mice
A botanical drug composed of three herbal materials attenuates the sensorimotor gating deficit and cognitive impairment induced by MK-801 in mice Open
Objectives A botanical drug derived from the ethanolic extract composed of Clematis chinensis Osbeck (Ranunculaceae), Trichosanthes kirilowii Maximowicz (Cucurbitaceae) and Prunella vulgaris Linné (Lamiaceae) has been used to ameliorate rh…
View article: Theracurmin Ameliorates Cognitive Dysfunctions in 5XFAD Mice by Improving Synaptic Function and Mitigating Oxidative Stress
Theracurmin Ameliorates Cognitive Dysfunctions in 5XFAD Mice by Improving Synaptic Function and Mitigating Oxidative Stress Open
As the elderly population is increasing, Alzheimer's disease (AD) has become a global issue and many clinical trials have been conducted to evaluate treatments for AD. As these clinical trials have been conducted and have failed, the devel…
View article: The Ameliorating Effects of Bee Pollen on Scopolamine-Induced Cognitive Impairment in Mice
The Ameliorating Effects of Bee Pollen on Scopolamine-Induced Cognitive Impairment in Mice Open
Bee pollen consists of floral pollen mixed with bee secretions and nectar. It has been considered as a functional food and has different kinds of biologically active ingredients, such as flavonoids, polyphenols, phytosterols and minerals. …
View article: Valproic Acid Induces Telomerase Reverse Transcriptase Expression during Cortical Development
Valproic Acid Induces Telomerase Reverse Transcriptase Expression during Cortical Development Open
[This corrects the article on p. 252 in vol. 26, PMID: 29093634.].
View article: Valproic Acid Induces Telomerase Reverse Transcriptase Expression during Cortical Development
Valproic Acid Induces Telomerase Reverse Transcriptase Expression during Cortical Development Open
The valproic acid (VPA)-induced animal model is one of the most widely utilized environmental risk factor models of autism. Autism spectrum disorder (ASD) remains an insurmountable challenge among neurodevelopmental disorders due to its he…
View article: Transcriptional profiling of <scp>SHR</scp>/<scp>NCrl</scp> prefrontal cortex shows hyperactivity‐associated genes responsive to amphetamine challenge
Transcriptional profiling of <span>SHR</span>/<span>NCrl</span> prefrontal cortex shows hyperactivity‐associated genes responsive to amphetamine challenge Open
Several studies suggest a strong genetic component of attention‐deficit/hyperactivity disorder ( ADHD ), a complex neurodevelopmental disorder characterized by inappropriate levels of hyperactivity, impulsivity and inattention. Determining…
View article: Eupatilin exerts neuroprotective effects in mice with transient focal cerebral ischemia by reducing microglial activation
Eupatilin exerts neuroprotective effects in mice with transient focal cerebral ischemia by reducing microglial activation Open
Microglial activation and its-driven neuroinflammation are characteristic pathogenetic features of neurodiseases, including focal cerebral ischemia. The Artemisia asiatica (Asteraceae) extract and its active component, eupatilin, are well-…
View article: Protection Against Electroshock- and Pentylenetetrazol-induced Seizures by the Water Extract of<i>Rehmannia glutinous</i>can be Mediated through GABA Receptor-chloride Channel Complexes
Protection Against Electroshock- and Pentylenetetrazol-induced Seizures by the Water Extract of<i>Rehmannia glutinous</i>can be Mediated through GABA Receptor-chloride Channel Complexes Open
Epilepsy is a brain disorder that affects millions of people worldwide. It is characterized by recurrent and unpredictable seizures that are usually controlled with antiepileptic/anticonvulsive drugs. However, most antiepileptic drugs prod…
View article: The Seed of <i>Zizyphus jujuba</i> var. <i>spinosa</i> Attenuates Alzheimer’s Disease-Associated Hippocampal Synaptic Deficits through BDNF/TrkB Signaling
The Seed of <i>Zizyphus jujuba</i> var. <i>spinosa</i> Attenuates Alzheimer’s Disease-Associated Hippocampal Synaptic Deficits through BDNF/TrkB Signaling Open
Ziziphus jujuba is a plant, which bears fruits and seeds that are used for medicinal purposes in Traditional oriental medicine. The seed of Zizyphus jujuba var. spinosa (EZJ) has been also traditionally used for psychiatric disorders in Ch…
View article: Echinocystic Acid Facilitates Neurite Outgrowth in Neuroblastoma Neuro2a Cells and Enhances Spatial Memory in Aged Mice
Echinocystic Acid Facilitates Neurite Outgrowth in Neuroblastoma Neuro2a Cells and Enhances Spatial Memory in Aged Mice Open
Aging leads to functional changes in the brain and decreases ability of learning and memory. Neurite outgrowth is important in learning and memory, therefore regulation of neurite outgrowth might be a candidate for treating aged brain. Ech…
View article: Altered Translational Control of Fragile X Mental Retardation Protein on Myelin Proteins in Neuropsychiatric Disorders
Altered Translational Control of Fragile X Mental Retardation Protein on Myelin Proteins in Neuropsychiatric Disorders Open
Myelin is a specialized structure of the nervous system that both enhances electrical conductance and insulates neurons from external risk factors. In the central nervous system, polarized oligodendrocytes form myelin by wrapping processes…
View article: Biflorin Ameliorates Memory Impairments Induced by Cholinergic Blockade in Mice
Biflorin Ameliorates Memory Impairments Induced by Cholinergic Blockade in Mice Open
To examine the effect of biflorin, a component of Syzygium aromaticum, on memory deficit, we introduced a scopolamine-induced cognitive deficit mouse model. A single administration of biflorin increased latency time in the passive avoidanc…