Jong Hwee Park
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View article: Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice
Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice Open
Type I interferons (IFNs) exert a broad range of biological effects important in coordinating immune responses, which have classically been studied in the context of pathogen clearance. Yet, whether immunomodulatory bacteria operate throug…
View article: Single-cell RNA sequencing of 76,535 capillary PBMCs from 3 donors across 28 samples, freshly isolated or on ice for 24h with manual 4-layer annotation hierarchy
Single-cell RNA sequencing of 76,535 capillary PBMCs from 3 donors across 28 samples, freshly isolated or on ice for 24h with manual 4-layer annotation hierarchy Open
Sample Procurement Samples were collected directly from participants as part of ImYoo's "Single-cell immune profiling from self-collected capillary blood" study, approved by Advarra IRB (Protocol #Pro00057361). Sample Processing Whole capi…
View article: Single-cell RNA sequencing of 76,535 capillary PBMCs from 3 donors across 28 samples, freshly isolated or on ice for 24h with manual 4-layer annotation hierarchy
Single-cell RNA sequencing of 76,535 capillary PBMCs from 3 donors across 28 samples, freshly isolated or on ice for 24h with manual 4-layer annotation hierarchy Open
Sample Procurement Samples were collected directly from participants as part of ImYoo's "Single-cell immune profiling from self-collected capillary blood" study, approved by Advarra IRB (Protocol #Pro00057361). Sample Processing Whole capi…
View article: Commensal bacteria promote type I interferon signaling to maintain immune tolerance
Commensal bacteria promote type I interferon signaling to maintain immune tolerance Open
Type I interferons (IFN) exert a broad range of biological effects important in coordinating immune responses. Host and microbial factors regulate IFN production, triggering a signaling cascade that has classically been studied in the cont…
View article: Enabling out-of-clinic human immunity studies via single-cell profiling of capillary blood
Enabling out-of-clinic human immunity studies via single-cell profiling of capillary blood Open
An individual’s immune system is driven by both genetic and environmental factors that vary over time. To better understand the temporal and inter-individual variability of gene expression within distinct immune cell types, we developed a …
View article: Highly Multiplexed Single-Cell RNA-seq for Defining Cell Population and Transcriptional Spaces
Highly Multiplexed Single-Cell RNA-seq for Defining Cell Population and Transcriptional Spaces Open
We describe a universal sample multiplexing method for single-cell RNA-seq in which cells are chemically labeled with identifying DNA oligonucleotides. Analysis of a 96-plex perturbation experiment revealed changes in cell population struc…