Jin Seok Kim
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View article: A hierarchical abscission program regulates reproductive allocation in <i>Prunus</i> × <i>yedoensis</i> and <i>Prunus sargentii</i>
A hierarchical abscission program regulates reproductive allocation in <i>Prunus</i> × <i>yedoensis</i> and <i>Prunus sargentii</i> Open
Organ abscission is essential for optimal reproduction, yet its regulation in perennial woody plant species is poorly understood. To investigate how abscission is spatially and temporally regulated during reproduction, we analyzed five seq…
View article: Impact of Cell-of-Origin and MYC/BCL2 Status on the Risk of Central Nervous System Relapse in Primary Breast Diffuse Large B-Cell Lymphoma
Impact of Cell-of-Origin and MYC/BCL2 Status on the Risk of Central Nervous System Relapse in Primary Breast Diffuse Large B-Cell Lymphoma Open
MYC/BCL2 DE and synchronous bilateral breast involvement may help identify patients at higher risk for CNS relapse. Further studies are warranted.
View article: Randomized Phase 3 study of pomalidomide cyclophosphamide dexamethasone versus pomalidomide dexamethasone in relapse or refractory myeloma: an Asian Myeloma Network study (AMN003)
Randomized Phase 3 study of pomalidomide cyclophosphamide dexamethasone versus pomalidomide dexamethasone in relapse or refractory myeloma: an Asian Myeloma Network study (AMN003) Open
Pomalidomide has been shown to improve survival in patients with relapsed/refractory myeloma (RRMM). However, the optimal pomalidomide-based combinations in RRMM are not known. This study compared pomalidomide, cyclophosphamide, dexamethas…
View article: Perspectives on Anti-BCMA Bispecific Antibodies use in Multiple Myeloma–Experience from Asian Countries
Perspectives on Anti-BCMA Bispecific Antibodies use in Multiple Myeloma–Experience from Asian Countries Open
The insights gained will contribute to developing strategic frameworks and consensus guidelines that can effectively guide clinicians in optimizing outcomes for myeloma patients in diverse healthcare settings.
View article: Dual Mechanistic Anti-Obesity Effects of Red Okra and <i>Diospyros lotus</i> Mixture via Fat Binding and AMPK-Mediated Lipid Metabolism
Dual Mechanistic Anti-Obesity Effects of Red Okra and <i>Diospyros lotus</i> Mixture via Fat Binding and AMPK-Mediated Lipid Metabolism Open
Obesity is a major global health issue associated with metabolic dysfunctions including dyslipidemia, insulin resistance, and hepatic steatosis. This study investigated the dual anti-obesity mechanisms of a combined extract of red okra (Ab…
View article: Entropy, Assessed by Homeostatic Dysregulation on Electrocardiograms Predicts Fracture and Mortality
Entropy, Assessed by Homeostatic Dysregulation on Electrocardiograms Predicts Fracture and Mortality Open
Entropy, characterized by increased disorder throughout biological systems, can be quantified by homeostatic dysregulation (HD). One potential measure of HD is the dispersion of points from a normal value, approximated at the individual le…
View article: Management of Atypical Haemolytic Uraemic Syndrome With Triggers: Diagnostic and Treatment Algorithms From an Asia‐Pacific Perspective
Management of Atypical Haemolytic Uraemic Syndrome With Triggers: Diagnostic and Treatment Algorithms From an Asia‐Pacific Perspective Open
Complement‐amplifying events/conditions associated with thrombotic microangiopathy (TMA) include pregnancy/postpartum period, severe hypertension, autoimmune diseases, drug exposures, infections and organ transplantation. Some of these ‘tr…
View article: Functional reorganization and taxonomic shifts in the symbiotic microbiota of the temperate soft coral Eleutherobia rubra under heat stress
Functional reorganization and taxonomic shifts in the symbiotic microbiota of the temperate soft coral Eleutherobia rubra under heat stress Open
Introduction Global ocean warming is known to disrupt interactions between corals and their symbiotic microbiota; however, the temporal sequence of structural and functional changes within microbial communities under thermal stress remains…
View article: Efficacy, safety, and health-related quality of life in transplant-ineligible newly diagnosed multiple myeloma patients receiving bortezomib maintenance therapy: a study of the Korean Multiple Myeloma Working Party (KMMWP-174 study)
Efficacy, safety, and health-related quality of life in transplant-ineligible newly diagnosed multiple myeloma patients receiving bortezomib maintenance therapy: a study of the Korean Multiple Myeloma Working Party (KMMWP-174 study) Open
Not available.
View article: A hierarchical abscission program regulates reproductive allocation in <i>Prunus yedoensis</i> and <i>Prunus sargentii</i>
A hierarchical abscission program regulates reproductive allocation in <i>Prunus yedoensis</i> and <i>Prunus sargentii</i> Open
Summary organ abscission is essential for optimal reproduction, yet its regulation in perennial woody plant species is poorly understood. To investigate how abscission is spatially and temporally regulated during reproduction, we analyzed …
View article: Targeting anemia-induced CD71 <sup>+</sup> reticulocytes protects mice from <i>Plasmodium</i> infection
Targeting anemia-induced CD71 <sup>+</sup> reticulocytes protects mice from <i>Plasmodium</i> infection Open
Malaria, caused by Plasmodium spp., is a global health concern linked to anemia and increased mortality. Compensatory erythropoiesis seen during acute anemia results in an increased circulating reticulocyte count (i.e., immature RBC), a ke…
View article: Review of Randomized Controlled Trials on Herbal Medicine for Influenza Prevention
Review of Randomized Controlled Trials on Herbal Medicine for Influenza Prevention Open
Objective: The purpose of this study was to review randomized controlled trials (RCTs) on herbal medicine for the prevention of influenza.Methods: Literature searches were performed on eight databases: PubMed, EMBASE, Cochrane Library, CNK…
View article: Gut Feelings: How Microbes, Diet, and Host Immunity Shape Disease
Gut Feelings: How Microbes, Diet, and Host Immunity Shape Disease Open
The human gut microbiome is intricately linked to systemic and organ-specific immune responses and is highly responsive to dietary modulation. As metagenomic techniques enable in-depth study of an ever-growing number of gut microbial speci…
View article: Simulation of harmful cyanobacterial blooms under weir operations and climate change scenarios: A data-driven study of the Nakdong River
Simulation of harmful cyanobacterial blooms under weir operations and climate change scenarios: A data-driven study of the Nakdong River Open
Climate change has caused widespread harmful cyanobacterial blooms (HCBs) worldwide. Although the hydraulic retention time affects the proliferation of cyanobacteria, changes in the frequency and intensity of HCBs under climate change in r…
View article: Real-World Use of carfilzomib-lenalidomide-dexamethasone (KRd) and carfilzomib-dexamethasone (Kd) in Relapsed/Refractory Multiple Myeloma in the Asia Pacific Region: A Prospective Multicenter Observational Study
Real-World Use of carfilzomib-lenalidomide-dexamethasone (KRd) and carfilzomib-dexamethasone (Kd) in Relapsed/Refractory Multiple Myeloma in the Asia Pacific Region: A Prospective Multicenter Observational Study Open
Carfilzomib administered as either KRd or Kd was effective and well tolerated, even in patients with multiple prior LOTs, confirming the safety and response rates observed from clinical trials and real-world studies.
View article: Efficacy and safety of rituximab biosimilar (DRL_RI) versus MabThera <sup>®</sup> in low-tumor-burden follicular lymphoma: the FLINTER study
Efficacy and safety of rituximab biosimilar (DRL_RI) versus MabThera <sup>®</sup> in low-tumor-burden follicular lymphoma: the FLINTER study Open
Background and objectives: This phase III study (RI-01-006; FLINTER) was conducted to demonstrate equivalent efficacy of DRL_RI to EU-approved rituximab (MabThera ® ) in patients with previously untreated Stage II–IV, CD20-positive, low-tu…
View article: Odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma: primary efficacy and safety analysis in phase 2 ELM-2 trial
Odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma: primary efficacy and safety analysis in phase 2 ELM-2 trial Open
The phase 2, multicohort, ongoing ELM-2 study evaluates odronextamab, a CD20×CD3 bispecific antibody, in patients with relapsed/refractory (R/R) B cell non-Hodgkin lymphoma after ≥2 lines of therapy. Here primary analysis of the diffuse la…
View article: Prevention and Management of Thromboembolism in Patients with Paroxysmal Nocturnal Hemoglobinuria in Asia: A Narrative Review
Prevention and Management of Thromboembolism in Patients with Paroxysmal Nocturnal Hemoglobinuria in Asia: A Narrative Review Open
Thromboembolism (TE) is a major cause of morbidity and mortality in patients with paroxysmal nocturnal hemoglobinuria (PNH). This narrative review summarizes available evidence on TE in Asian patients with PNH and discusses practical consi…
View article: Targeting anemia-induced CD71<sup>+</sup>reticulocytes protects mice from<i>Plasmodium</i>infection
Targeting anemia-induced CD71<sup>+</sup>reticulocytes protects mice from<i>Plasmodium</i>infection Open
Malaria, caused by Plasmodium spp., is a global health concern linked to anemia and increased mortality. Compensatory erythropoiesis seen during acute anemia results in an increased circulating reticulocyte count ( i.e. , immature RBC) a k…
View article: Monitoring and Treatment of Paroxysmal Nocturnal Hemoglobinuria in Patients with Aplastic Anemia in Asia: An Expert Consensus
Monitoring and Treatment of Paroxysmal Nocturnal Hemoglobinuria in Patients with Aplastic Anemia in Asia: An Expert Consensus Open
Paroxysmal nocturnal hemoglobinuria (PNH) clones can be identified in a significant proportion of patients with aplastic anemia (AA). Screening for PNH clones at the time of an AA diagnosis is recommended by national and international guid…
View article: Phase III COMMODORE 1 Trial: 2-Year Efficacy and Safety of Crovalimab in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Switched from Ravulizumab
Phase III COMMODORE 1 Trial: 2-Year Efficacy and Safety of Crovalimab in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Switched from Ravulizumab Open
Introduction Crovalimab (crova; PiaSky®), a novel C5 inhibitor (C5i) allowing for maintenance subcutaneous (SC) injection every 4 wks (Q4W), was evaluated in the global, randomized, Phase III COMMODORE 1 and 2 trials (NCT04432584; NCT04434…
View article: Global outcomes and prognosis for relapsed/refractory mature T-cell and NK-cell lymphomas: results from the PETAL consortium
Global outcomes and prognosis for relapsed/refractory mature T-cell and NK-cell lymphomas: results from the PETAL consortium Open
Variances in global access to drugs and treatment practices make it challenging to understand the benefit of contemporary therapies in patients with relapsed and refractory (R/R) mature T-cell and natural killer–cell lymphomas (MTCL and MN…
View article: Physicochemical Properties of Low-Molecular-Weight Homogalacturonan Pectin from Enzyme-Hydrolyzed Red Okra
Physicochemical Properties of Low-Molecular-Weight Homogalacturonan Pectin from Enzyme-Hydrolyzed Red Okra Open
In this study, we focused on reducing the molecular weight of purified red okra pectin using various hydrolytic enzymes and evaluating its physicochemical properties or characterization. The enzyme treatments targeted both the main pectin …
View article: A Case Report of Korean Medicine Treatment for Chronic Obstructive Pulmonary Disease Patient with Dyspepsia and Anorexia after Surgery for Colon Cancer and Chemotherapy
A Case Report of Korean Medicine Treatment for Chronic Obstructive Pulmonary Disease Patient with Dyspepsia and Anorexia after Surgery for Colon Cancer and Chemotherapy Open
Objectives: The purpose of this case study was to report the therapeutic effect of Korean medicine treatment for chronic obstructive pulmonary disease (COPD) patient with dyspepsia and anorexia after surgery for colon cancer and chemothera…
View article: Phase 3 randomized COMMODORE 1 trial: Crovalimab versus eculizumab in complement inhibitor‐experienced patients with paroxysmal nocturnal hemoglobinuria
Phase 3 randomized COMMODORE 1 trial: Crovalimab versus eculizumab in complement inhibitor‐experienced patients with paroxysmal nocturnal hemoglobinuria Open
Crovalimab, a novel C5 inhibitor, allows for low‐volume, every‐4‐ week, subcutaneous self‐administration. COMMODORE 1 (NCT04432584) is a phase 3, global, randomized trial evaluating crovalimab versus eculizumab in C5 inhibitor‐experienced …
View article: Variation in immunoglobulin use and impact on survival in myeloma
Variation in immunoglobulin use and impact on survival in myeloma Open
Serious infection is common in patients with multiple myeloma due to immune deficiency from the underlying disease and/or its treatment. Immunoglobulin replacement is one approach to reduce infection risk in these patients. However, few re…