Jong Pil Im
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View article: Asiatic acid inhibits NF-κB signaling and ameliorates experimental acute and chronic colitis in mice
Asiatic acid inhibits NF-κB signaling and ameliorates experimental acute and chronic colitis in mice Open
Objective: This study aimed to elucidate the anti-inflammatory mechanisms of asiatic acid (AA) by focusing on its modulation of the nuclear factor-κB (NF-κB) signaling pathway and to evaluate its therapeutic effects in murine models of bot…
View article: Comparative Efficacy and Safety of 0.8‐L Versus 2‐L Polyethylene Glycol‐Ascorbic Acid Solutions in Colonoscopy Preparation: A Prospective, Multicenter, Randomized, Controlled Trial
Comparative Efficacy and Safety of 0.8‐L Versus 2‐L Polyethylene Glycol‐Ascorbic Acid Solutions in Colonoscopy Preparation: A Prospective, Multicenter, Randomized, Controlled Trial Open
Background and Aim High‐volume polyethylene glycol (PEG) solutions are associated with low patient compliance, whereas low‐volume alternatives pose higher risks of adverse events. We compared a new 0.8‐L PEG–ascorbic acid solution containi…
View article: A real-world comparison of subcutaneous to intravenous administration of infliximab in patients with inflammatory bowel disease
A real-world comparison of subcutaneous to intravenous administration of infliximab in patients with inflammatory bowel disease Open
Background/Aims: We compared intravenous and subcutaneous infliximab (IFX) as treatment for inflammatory bowel disease (IBD). Methods: This retrospective, multicenter, observational study enrolled patients treated with either intravenous o…
View article: AI-powered 3D pathology protocol enhances enteric nervous system visualization and quantification for clinical diagnostics
AI-powered 3D pathology protocol enhances enteric nervous system visualization and quantification for clinical diagnostics Open
Rationale: Accurate diagnosis and understanding of gastrointestinal (GI) diseases such as ulcerative colitis and Hirschsprung's disease remain challenging due to the limitations of traditional two-dimensional (2D) histopathology in capturi…
View article: Clinical Outcome of Inflammatory Bowel Disease with Clostridioides difficile Polymerase Chain Reaction Toxin-Positive/Enzyme Immunoassay Toxin-Negative: A Retrospective Cohort Study
Clinical Outcome of Inflammatory Bowel Disease with Clostridioides difficile Polymerase Chain Reaction Toxin-Positive/Enzyme Immunoassay Toxin-Negative: A Retrospective Cohort Study Open
In patients with IBD with indeterminate CDI, the need for antibiotics should be thoroughly assessed and proper management of underlying IBD such as drug escalation may lead to favorable outcomes.
View article: Early Progression Prediction in Korean Crohn’s Disease Using a Korean-Specific PrediXcan Model
Early Progression Prediction in Korean Crohn’s Disease Using a Korean-Specific PrediXcan Model Open
Crohn’s disease (CD) is a chronic inflammatory disorder with potential progression to stricturing (B2) or penetrating (B3) phenotypes, leading to significant complications. Early identification of patients at risk for these complications i…
View article: P0474 Five-Year Clinical Outcomes and Disease Course of Newly-Diagnosed Moderate-to-Severe Ulcerative Colitis: A Prospective Nationwide Multicentre MOSAIK Cohort Study in Korea
P0474 Five-Year Clinical Outcomes and Disease Course of Newly-Diagnosed Moderate-to-Severe Ulcerative Colitis: A Prospective Nationwide Multicentre MOSAIK Cohort Study in Korea Open
Background While the incidence of moderate-to-severe ulcerative colitis (UC) is rising in Asia, comprehensive data on its long-term disease course in Asian populations remain scarce. Methods The MOSAIK (MOderate-to-Severe ulcerAtive colIti…
View article: P0296 Comparison of clinical characteristics of Montreal classification group A3 patients with Crohn’s disease in Korea: Results from the Prospective and Retrospective CONNECT Study
P0296 Comparison of clinical characteristics of Montreal classification group A3 patients with Crohn’s disease in Korea: Results from the Prospective and Retrospective CONNECT Study Open
Background The CONNECT study, a nationwide multicenter cohort study of Crohn’s disease (CD) in Korea, was designed to investigate the clinical characteristics and long-term prognosis of CD patients. Starting in 2009, the study enrolled pat…
View article: P0176 Single-cell RNA sequencing reveals the immunological mechanisms underlying Anti-saccharomyces cerevisiae antibody positivity in both non-inflamed and inflamed mucosal tissues of IBD patients
P0176 Single-cell RNA sequencing reveals the immunological mechanisms underlying Anti-saccharomyces cerevisiae antibody positivity in both non-inflamed and inflamed mucosal tissues of IBD patients Open
Background Previous studies have shown anti-saccharomyces cerevisiae antibody (ASCA) positivity in inflammatory bowel disease (IBD) patients is associated with increased risk of developing IBD and poor prognosis. However, no comprehensive …
View article: A Chronic Psoriasis Model Using Long-Term Imiquimod Application in IL-10-Deficient Mice: Recapitulating Skin Inflammation, Comorbidities, and Gut–Skin Axis Alterations
A Chronic Psoriasis Model Using Long-Term Imiquimod Application in IL-10-Deficient Mice: Recapitulating Skin Inflammation, Comorbidities, and Gut–Skin Axis Alterations Open
The 6-week IMQ-applied IL-10 KO model may better reflect chronic and severe psoriasis with gut-related comorbidities, offering a valuable platform to investigate the gut-skin axis.
View article: Toll-like receptor 3 signaling attenuated colitis-associated cancer development in mice
Toll-like receptor 3 signaling attenuated colitis-associated cancer development in mice Open
Inflammatory bowel disease is associated with a high risk of colitis-associated cancer (CAC). We evaluated the role of TLR3 in CAC using a murine model. Wild-type (WT) and TLR3-knockout (TLR3-/-) mice received azoxymethane (AOM) 12.5 mg/kg…
View article: OD32 Single Nucleotide Polymorphism Marker Analysis In Donor-Derived Cell-Free DNA For Solid Organ Transplantation (Next-Generation Sequencing): Systematic Review
OD32 Single Nucleotide Polymorphism Marker Analysis In Donor-Derived Cell-Free DNA For Solid Organ Transplantation (Next-Generation Sequencing): Systematic Review Open
Introduction Single nucleotide polymorphism marker analysis in donor-derived cell-free (dd-cf ) DNA for solid organ transplantation is a technique for post-transplantation monitoring, including early detection of injury to the transplanted…
View article: Predictors of histologic remission in patients with biologic-naïve, moderate-to-severe ulcerative colitis treated with first-line biologic agents and small-molecule drugs: a single-center, retrospective cohort study
Predictors of histologic remission in patients with biologic-naïve, moderate-to-severe ulcerative colitis treated with first-line biologic agents and small-molecule drugs: a single-center, retrospective cohort study Open
We confirmed that the overweight category was a predictor of histological remission after first-line treatment with a biological agent. However, as BMI does not account for skeletal muscle mass, future studies are required to confirm the c…
View article: Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea, 2010-2018
Recent trends in the epidemiology and clinical outcomes of inflammatory bowel disease in South Korea, 2010-2018 Open
BACKGROUND Inflammatory bowel disease (IBD) was previously regarded as a Western disease; however, its incidence is increasing in the East. The epidemiology of IBD in Asia differs significantly from the patterns in the West. AIM To compreh…
View article: P472 A Real World Practice of Intestinal Ultrasound in the Monitoring of Disease Activity in Ulcerative Colitis
P472 A Real World Practice of Intestinal Ultrasound in the Monitoring of Disease Activity in Ulcerative Colitis Open
Background Intestinal ultrasound (IUS) has emerged as an important monitoring tool in the clinical course of ulcerative colitis (UC). Previously known factors about UC have been considered in terms of the associations with IUS. However, a …
View article: P1107 Clinical characteristics and prognosis of very young adult-onset Crohn's disease: Results from the Prospective CONNECT Study
P1107 Clinical characteristics and prognosis of very young adult-onset Crohn's disease: Results from the Prospective CONNECT Study Open
Background Although the A2 group according to the Montreal classification accounts for the largest proportion among patients with Crohn’s disease (CD),1 there has been a lack of studies comparing the clinical characteristics and prognosis …
View article: Enrichment of Activated Fibroblasts as a Potential Biomarker for a Non-Durable Response to Anti-Tumor Necrosis Factor Therapy in Patients with Crohn’s Disease
Enrichment of Activated Fibroblasts as a Potential Biomarker for a Non-Durable Response to Anti-Tumor Necrosis Factor Therapy in Patients with Crohn’s Disease Open
We investigated whether the response to anti-tumor necrosis factor (anti-TNF) treatment varied according to inflammatory tissue characteristics in Crohn’s disease (CD). Bulk RNA sequencing (RNA-seq) data were obtained from inflamed and non…
View article: Regulation of psoriasis, colitis, and the intestinal microbiota by clusterin
Regulation of psoriasis, colitis, and the intestinal microbiota by clusterin Open
Psoriasis, a chronic and systemic inflammatory disorder characterized by activation of the interleukin (IL)-23/IL-17 axis, may be associated with the intestinal microbiota through the so-called “gut–skin axis.” Clusterin is a glycoprotein …
View article: Migraine Is Associated with the Development of Inflammatory Bowel Disease: A Nationwide, Population-Based Study
Migraine Is Associated with the Development of Inflammatory Bowel Disease: A Nationwide, Population-Based Study Open
Background: It has been reported that migraine is more common in patients with inflammatory bowel disease (IBD) than in general. However, the impact of migraine on the development of IBD has not yet been elucidated. The aim of this study w…
View article: Infectious complications in patients with inflammatory bowel disease in Asia: the results of a multinational web-based survey in the 8th Asian Organization for Crohn’s and Colitis meeting
Infectious complications in patients with inflammatory bowel disease in Asia: the results of a multinational web-based survey in the 8th Asian Organization for Crohn’s and Colitis meeting Open
Background/Aims: Infectious complications are major concerns when treating patients with inflammatory bowel disease (IBD). This study evaluated clinical differences across countries/regions in the management of infectious diseases in patie…
View article: Changes in fecal metabolic and lipidomic features by anti-TNF treatment and prediction of clinical remission in patients with ulcerative colitis
Changes in fecal metabolic and lipidomic features by anti-TNF treatment and prediction of clinical remission in patients with ulcerative colitis Open
Background: Therapeutic targets for ulcerative colitis (UC) and prediction models of antitumor necrosis factor (TNF) therapy outcomes have not been fully reported. Objective: Investigate the characteristic metabolite and lipid profiles of …
View article: Association between severe hepatic steatosis examined by Fibroscan and the risk of high-risk colorectal neoplasia
Association between severe hepatic steatosis examined by Fibroscan and the risk of high-risk colorectal neoplasia Open
The prevalence of colorectal neoplasm in patients with non-alcoholic fatty liver disease has increased twice as high as that in the general population. FibroScan is a new modality for evaluating hepatic steatosis. This study aimed to inves…
View article: Association of Waist Circumference with the Risk of Inflammatory Bowel Disease: a Nationwide Cohort Study of 10 Million Individuals in Korea
Association of Waist Circumference with the Risk of Inflammatory Bowel Disease: a Nationwide Cohort Study of 10 Million Individuals in Korea Open
Background and Aims Metabolic syndrome may share the pathophysiology of adipose tissue dysregulation and inadequate immune response with inflammatory bowel disease [IBD]. We determined the association of abdominal obesity [AO] with the ris…
View article: Impact of Crohn’s Disease on the Survival of Patients with Small-Bowel Adenocarcinoma in Korea: A Bicenter Cohort Study
Impact of Crohn’s Disease on the Survival of Patients with Small-Bowel Adenocarcinoma in Korea: A Bicenter Cohort Study Open
The overall survival of patients with CD-associated SBA did not differ from that of patients with sporadic SBA. However, as CD is an independent risk factor for mortality, vigilant surveillance in high-risk patients may be crucial.