JongHoon Ha
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View article: Adaptive design of mRNA-loaded extracellular vesicles for targeted immunotherapy of cancer
Adaptive design of mRNA-loaded extracellular vesicles for targeted immunotherapy of cancer Open
The recent success of mRNA therapeutics against pathogenic infections has increased interest in their use for other human diseases including cancer. However, the precise delivery of the genetic cargo to cells and tissues of interest remain…
View article: Combination Cancer Immunotherapy: Immunogenic Cell Death Inducing Fluorinated Mitochondria‐Disrupting Helical Polypeptide Synergizes with PD‐L1 Immune Checkpoint Blockade (Adv. Sci. 7/2021)
Combination Cancer Immunotherapy: Immunogenic Cell Death Inducing Fluorinated Mitochondria‐Disrupting Helical Polypeptide Synergizes with PD‐L1 Immune Checkpoint Blockade (Adv. Sci. 7/2021) Open
In article number 2001308, Chae‐Ok Yun, Yeu‐Chun Kim, and co‐workers develop endoplasmic reticulum (ER) stress‐mediated immunogenic cell death (ICD) inducing fluorinated mitochondria‐disrupting helical polypeptides (MDHPs). These helical p…
View article: Drug Development: A Helical Polypeptide‐Based Potassium Ionophore Induces Endoplasmic Reticulum Stress‐Mediated Apoptosis by Perturbing Ion Homeostasis (Adv. Sci. 14/2019)
Drug Development: A Helical Polypeptide‐Based Potassium Ionophore Induces Endoplasmic Reticulum Stress‐Mediated Apoptosis by Perturbing Ion Homeostasis (Adv. Sci. 14/2019) Open
In article number of 1801995, Chae‐Ok Yun, Yeu‐Chun Kim, and co‐workers develop helical polypeptide‐based potassium ionophores that can drive out potassium ions from the cytosol. The perturbed potassium homeostasis strongly inflicts endopl…