Jong‐Il Kim
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View article: Micro-scale control of oligodendrocyte morphology and myelination by the intellectual disability-linked protein acyltransferase ZDHHC9
Micro-scale control of oligodendrocyte morphology and myelination by the intellectual disability-linked protein acyltransferase ZDHHC9 Open
Mutations in the X-linked ZDHHC9 gene cause cognitive deficits in humans, with a subset of patients suffering from epilepsy. X-linked intellectual disability (XLID) is often ascribed to neuronal deficits, but here we report that expression…
View article: Defensive tolerance drives the reprogramming and dysfunction of infiltrating pathogenic B cells assuring the maintenance of tolerance
Defensive tolerance drives the reprogramming and dysfunction of infiltrating pathogenic B cells assuring the maintenance of tolerance Open
We previously showed that infiltrating cytotoxic immune cells are reprogrammed to regulatory-like/exhausted cells within accepted kidney allografts through a ‘defensive tolerance’ mechanism. We observed a regulatory B cell (Breg) signature…
View article: Association of high‐dose radioactive iodine therapy with <scp>PPM1D</scp> ‐mutated clonal hematopoiesis in older individuals
Association of high‐dose radioactive iodine therapy with <span>PPM1D</span> ‐mutated clonal hematopoiesis in older individuals Open
While radioactive iodine therapy (RAIT) has been an effective treatment for thyroid cancer, its link to clonal hematopoiesis (CH) has been yet underexplored. In this study, error‐corrected sequencing (median depth: 1926×) of 93 CH‐related …
View article: Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9
Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9 Open
Mutations in the X-linked ZDHHC9 gene cause cognitive deficits in humans, with a subset of patients suffering from epilepsy. X-linked intellectual disability (XLID) is often ascribed to neuronal deficits, but here we report that expression…
View article: Elastic Relaxation of Coherent InGaN/GaN Interfaces at the Microwire LED Sidewall (Adv. Sci. 19/2025)
Elastic Relaxation of Coherent InGaN/GaN Interfaces at the Microwire LED Sidewall (Adv. Sci. 19/2025) Open
Light Emitting Diodes Microwire LEDs offer high luminance and superior pixel density per inch, making them ideal for next‐generation displays. Strain mapping and finite element simulation reveal that interfacial shear strain arises at trac…
View article: Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8<sup>+</sup> T cells
Novel anti-CD73-IL-2v bispecific fusion protein augments antitumor immunity by alleviating immunosuppressive adenosine pathways in CD8<sup>+</sup> T cells Open
Background Adenosine accumulated in the tumor microenvironment functions as an immune-modulating factor, exerting immunosuppressive actions via adenosine A2A/A2B receptor (A2AR/A2BR) in various immune cell types. CD73, a key enzymatic regu…
View article: Elastic Relaxation of Coherent InGaN/GaN Interfaces at the Microwire LED Sidewall
Elastic Relaxation of Coherent InGaN/GaN Interfaces at the Microwire LED Sidewall Open
Elastic relaxation of lattice misfit strain via traction‐free surface results in complex 3D strain distribution and morphological modification at the boundary of epitaxial heterostructure. While this phenomenon is extensively studied, the …
View article: Genomic profiling of intimal sarcoma reveals molecular subtypes with distinct tumor microenvironments and therapeutic implications
Genomic profiling of intimal sarcoma reveals molecular subtypes with distinct tumor microenvironments and therapeutic implications Open
We identified two intimal sarcoma molecular subtypes. Compared with CNV-H, MSI-H-like is enriched in pathways associated with tumor immune responses and TILs. Further efforts and clinical trials to better define these molecular subtypes ar…
View article: Physician–Scientist Training System and Development Strategies in Korea
Physician–Scientist Training System and Development Strategies in Korea Open
Physician-scientists play a pivotal role in bridging clinical practice and biomedical research, advancing medical science, and tackling complex healthcare challenges. In South Korea, the declining number of medical doctors engaging in basi…
View article: Fabrication and High-Temperature Performance Evaluation of Light-Weight Insulation Materials and Coatings for Reusable Thermal Protection Systems
Fabrication and High-Temperature Performance Evaluation of Light-Weight Insulation Materials and Coatings for Reusable Thermal Protection Systems Open
Light-weight ceramic insulation materials and high-emissivity coatings were fabricated for reusable thermal protection systems (TPS). Alumina-silica fibers and boric acid were used to fabricate the insulation, which was heat treated at 125…
View article: Neuroplasticity therapy using glia-like cells derived from human mesenchymal stem cells for the recovery of cerebral infarction sequelae
Neuroplasticity therapy using glia-like cells derived from human mesenchymal stem cells for the recovery of cerebral infarction sequelae Open
Despite a dramatic increase in ischemic stroke incidence worldwide, effective therapies for attenuating sequelae of cerebral infarction are lacking. This study investigates the use of human mesenchymal stem cells (hMSCs) induced toward gli…
View article: Effect of TiO2 Content on High-Temperature Degradation Behavior of Nd2O3 and Yb2O3–Doped YSZ Composite Materials
Effect of TiO2 Content on High-Temperature Degradation Behavior of Nd2O3 and Yb2O3–Doped YSZ Composite Materials Open
Hot section components of gas turbines are exposed to a high operating temperature environment. To protect these components, thermal barrier coatings (TBC) are applied to their surfaces. Yttria-stabilized zirconia (YSZ), which is widely us…
View article: Inter-laminar Strength of NITE-SiC/SiC Composites with Various Fiber Reinforcing Architecture
Inter-laminar Strength of NITE-SiC/SiC Composites with Various Fiber Reinforcing Architecture Open
The mechanical performance of SiC/SiC composites is significantly influenced by the architecture of fiber reinforcement. Among the various fabrication methods, the nano-powder infiltration transition/eutectic (NITE) process is a promising …
View article: Assembly of glioblastoma tumoroids and cerebral organoids: a <scp>3D</scp><i>in vitro</i> model for tumor cell invasion
Assembly of glioblastoma tumoroids and cerebral organoids: a <span>3D</span><i>in vitro</i> model for tumor cell invasion Open
Glioblastoma (GBM) has a fatal prognosis because of its aggressive and invasive characteristics. Understanding the mechanism of invasion necessitates an elucidation of the relationship between tumor cells and the tumor microenvironment. Ho…
View article: Supplementary Tables and Figures from Triple-negative breast cancer-derived extracellular vesicles promote a hepatic pre-metastatic niche via a cascade of microenvironment remodeling
Supplementary Tables and Figures from Triple-negative breast cancer-derived extracellular vesicles promote a hepatic pre-metastatic niche via a cascade of microenvironment remodeling Open
Supplementary Table 1. Information about patients derived xenograft models and derived patient. Supplementary Table 2. Ontology of differentially expressed genes in metastasis-harboring liver of PDX models. Supplementary Table 3. Different…
View article: Supplementary Tables and Figures from Triple-negative breast cancer-derived extracellular vesicles promote a hepatic pre-metastatic niche via a cascade of microenvironment remodeling
Supplementary Tables and Figures from Triple-negative breast cancer-derived extracellular vesicles promote a hepatic pre-metastatic niche via a cascade of microenvironment remodeling Open
Supplementary Table 1. Information about patients derived xenograft models and derived patient. Supplementary Table 2. Ontology of differentially expressed genes in metastasis-harboring liver of PDX models. Supplementary Table 3. Different…
View article: Data from Triple-negative breast cancer-derived extracellular vesicles promote a hepatic pre-metastatic niche via a cascade of microenvironment remodeling
Data from Triple-negative breast cancer-derived extracellular vesicles promote a hepatic pre-metastatic niche via a cascade of microenvironment remodeling Open
Triple negative breast cancer (TNBC) patients often develop metastases in visceral organs including the liver but the detailed molecular mechanisms of TNBC liver metastasis is not clearly understood. In this study, we tried to dissect the …
View article: Blockade of STING activation alleviates microglial dysfunction and a broad spectrum of Alzheimer’s disease pathologies
Blockade of STING activation alleviates microglial dysfunction and a broad spectrum of Alzheimer’s disease pathologies Open
Abnormal glial activation promotes neurodegeneration in Alzheimer’s disease (AD), the most common cause of dementia. Stimulation of the cGAS-STING pathway induces microglial dysfunction and sterile inflammation, which exacerbates AD. We sh…
View article: Micro-scale control of oligodendrocyte morphology and myelination by the intellectual disability-linked protein acyltransferase ZDHHC9
Micro-scale control of oligodendrocyte morphology and myelination by the intellectual disability-linked protein acyltransferase ZDHHC9 Open
Mutations in the X-linked ZDHHC9 gene cause cognitive deficits in humans, with a subset of patients suffering from epilepsy. X-linked intellectual disability (XLID) is often ascribed to neuronal deficits, but here we report that expression…
View article: Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9
Micro-Scale Control of Oligodendrocyte Morphology and Myelination by the Intellectual Disability-Linked Protein Acyltransferase ZDHHC9 Open
Mutations in the X-linked ZDHHC9 gene cause cognitive deficits in humans, with a subset of patients suffering from epilepsy. X-linked intellectual disability (XLID) is often ascribed to neuronal deficits, but here we report that expression…
View article: Harnessing Institutionally Developed Clinical Targeted Sequencing to Improve Patient Survival in Breast Cancer: A Seven-Year Experience
Harnessing Institutionally Developed Clinical Targeted Sequencing to Improve Patient Survival in Breast Cancer: A Seven-Year Experience Open
Purpose Considering the high disease burden and unique features of Asian patients with breast cancer (BC), it is essential to have a comprehensive view of genetic characteristics in this population. An institutional targeted sequencing pla…