Jongwon Im
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View article: DDDR-45. Probiotics Engineered for Specificity and Reduced Immunogenicity Improve Survival in a Glioma Model
DDDR-45. Probiotics Engineered for Specificity and Reduced Immunogenicity Improve Survival in a Glioma Model Open
Glioblastoma multiforme (GBM) is an aggressive cancer with a dismal prognosis despite standard care—maximal safe resection, chemotherapy, and radiation. GBM’s highly immunosuppressive environment has limited immunotherapy approaches. Bacte…
View article: Probiotic neoantigen delivery vectors for precision cancer immunotherapy
Probiotic neoantigen delivery vectors for precision cancer immunotherapy Open
Microbial systems have been synthetically engineered to deploy therapeutic payloads in vivo1,2. With emerging evidence that bacteria naturally home in on tumours3,4 and modulate antitumour immunity5,6, one promising application is the deve…
View article: Chronic Opioid Treatment Arrests Neurodevelopment and Alters Synaptic Activity in Human Midbrain Organoids
Chronic Opioid Treatment Arrests Neurodevelopment and Alters Synaptic Activity in Human Midbrain Organoids Open
Understanding the impact of long‐term opioid exposure on the embryonic brain is critical due to the surging number of pregnant mothers with opioid dependency. However, this has been limited by human brain inaccessibility and cross‐species …
View article: Probiotic-guided CAR-T cells for solid tumor targeting
Probiotic-guided CAR-T cells for solid tumor targeting Open
A major challenge facing tumor-antigen targeting therapies such as chimeric antigen receptor (CAR)–T cells is the identification of suitable targets that are specifically and uniformly expressed on heterogeneous solid tumors. By contrast, …
View article: Probiotic neoantigen delivery vectors for precision cancer immunotherapy
Probiotic neoantigen delivery vectors for precision cancer immunotherapy Open
Microbial systems have been synthetically engineered to deploy therapeutic payloads in vivo 1–4 . With emerging evidence that bacteria naturally home to tumors 5–7 and modulate anti-tumor immunity 8,9 , one promising application is the dev…
View article: Colorectal cancer detection and treatment with engineered probiotics
Colorectal cancer detection and treatment with engineered probiotics Open
Bioengineered probiotics enable new opportunities to improve colorectal cancer (CRC) screening, prevention and treatment strategies. Here, we demonstrate the phenomenon of selective, long-term colonization of colorectal adenomas after oral…
View article: A programmable probiotic encapsulation system enhances therapeutic delivery <i>in vivo</i>
A programmable probiotic encapsulation system enhances therapeutic delivery <i>in vivo</i> Open
Recent advances in therapeutic modulation of human microbiota have driven new efforts to engineer living microbial medicines using synthetic biology. However, a long-standing challenge for live bacterial therapies is balancing the high dos…
View article: Chronic opioid treatment arrests neurodevelopment and alters synaptic activity in human midbrain organoids
Chronic opioid treatment arrests neurodevelopment and alters synaptic activity in human midbrain organoids Open
Summary The impact of long-term opioid exposure on the embryonic brain is crucial to healthcare due to the surging number of pregnant mothers with an opioid dependency. Current studies on the neuronal effects are limited due to human brain…