Jong Youl Kim
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View article: The Role of Agmatine in Modulating Autophagy Under Neuroinflammatory Conditions Induced by Metabolic Alteration in Mouse Brain
The Role of Agmatine in Modulating Autophagy Under Neuroinflammatory Conditions Induced by Metabolic Alteration in Mouse Brain Open
Changes in microglia, a specialized population of glial cells found in the central nervous system (CNS), is often associated with hyperglycemic conditions. It has been reported that exogenous administration of agmatine (agm) has neuroprote…
View article: Ischemic stroke outcome after promoting CD4+CD25+ Treg cell migration through CCR4 overexpression in a tMCAO animal model
Ischemic stroke outcome after promoting CD4+CD25+ Treg cell migration through CCR4 overexpression in a tMCAO animal model Open
The importance of neuroinflammation during the ischemic stroke has been extensively studied. The role of CD4+CD25+ regulatory T (Treg) cells during the recovery phase have shown infarct size reduction and functional improvement, possibly t…
View article: SGLT2 and DPP4 inhibitors improve Alzheimer’s disease‐like pathology and cognitive function through distinct mechanisms in T2D‐AD mouse model
SGLT2 and DPP4 inhibitors improve Alzheimer’s disease‐like pathology and cognitive function through distinct mechanisms in T2D‐AD mouse model Open
Background There are common mechanisms between Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2D), such as insulin resistance. As insulin signaling has important roles in regulation of neuronal functions in the brain, the hypothes…
View article: SGLT2 and DPP4 inhibitors improve Alzheimer’s disease–like pathology and cognitive function through distinct mechanisms in a T2D–AD mouse model
SGLT2 and DPP4 inhibitors improve Alzheimer’s disease–like pathology and cognitive function through distinct mechanisms in a T2D–AD mouse model Open
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2D) share common features, including insulin resistance. Brain insulin resistance has been implicated as a key factor in the pathogenesis of AD. Recent studies have demonstrated that …
View article: Use of Botulinum Toxin for Limb Immobilization for Rehabilitation in Rats with Experimental Stroke
Use of Botulinum Toxin for Limb Immobilization for Rehabilitation in Rats with Experimental Stroke Open
Motor rehabilitation strategies after unilateral stroke suggest that the immobilization of the healthy, unimpaired limb can promote the functional recovery of a paretic limb. In rodents, this has been modeled using casts, harnesses, and ot…
View article: Unbound IRF2 to IRF2BP2 mediates KLF4 signaling leading to anti-inflammatory phenotype of microglia
Unbound IRF2 to IRF2BP2 mediates KLF4 signaling leading to anti-inflammatory phenotype of microglia Open
Background Following central nervous system (CNS) injury, the investigation for neuroinflammation is vital because of its pleiotropic role in both acute injury and long-term recovery. Agmatine (Agm) is well known for its neuroprotective ef…
View article: Therapeutic hypothermia for stroke: Unique challenges at the bedside
Therapeutic hypothermia for stroke: Unique challenges at the bedside Open
Therapeutic hypothermia has shown promise as a means to improving neurological outcomes at several neurological conditions. At the clinical level, it has been shown to improve outcomes in comatose survivors of cardiac arrest and in neonata…
View article: CCR4 and CCR5 Involvement in Monocyte-Derived Macrophage Migration in Neuroinflammation
CCR4 and CCR5 Involvement in Monocyte-Derived Macrophage Migration in Neuroinflammation Open
Microglia, resident macrophages in the brain, play major roles in neuroinflammation after an acute many neurological diseases, including stroke. Our recent animal stroke model showed that interleukin (IL)-4 and IL-13 released by microglia …
View article: Role of DPP-4 and SGLT2 Inhibitors Connected to Alzheimer Disease in Type 2 Diabetes Mellitus
Role of DPP-4 and SGLT2 Inhibitors Connected to Alzheimer Disease in Type 2 Diabetes Mellitus Open
Alzheimer’s disease (AD) is characterized by memory loss and cognitive decline. Additionally, abnormal extracellular amyloid plaques accumulation and nerve damage caused by intracellular neurofibrillary tangles, and tau protein are charact…
View article: Carbon Nanotubes Impregnated with Subventricular Zone Neural Progenitor Cells Promotes Recovery from Stroke [Corrigendum]
Carbon Nanotubes Impregnated with Subventricular Zone Neural Progenitor Cells Promotes Recovery from Stroke [Corrigendum] Open
[This corrects the article DOI: 10.2147/IJN.S30273.].
View article: Role of agmatine in the application of neural progenitor cell in central nervous system diseases: therapeutic potentials and effects
Role of agmatine in the application of neural progenitor cell in central nervous system diseases: therapeutic potentials and effects Open
Agmatine, the primary decarboxylation product of L-arginine, generated from arginine decarboxylase. Since the discovery of agmatine in the mammalian brain in the 1990s, an increasing number of agmatine-mediated effects have been discovered…
View article: Maintenance of the Neuroprotective Function of the Amino Group Blocked Fluorescence-Agmatine
Maintenance of the Neuroprotective Function of the Amino Group Blocked Fluorescence-Agmatine Open
Agmatine, an endogenous derivative of arginine, has been found to be effective in treating idiopathic pain, convulsion, stress-mediated behavior, and attenuate the withdrawal symptoms of drugs like morphine. In the early stages of ischemic…
View article: Corrigendum: Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?
Corrigendum: Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke? Open
[This corrects the article DOI: 10.3389/fneur.2020.578003.].
View article: Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke?
Monocyte Transmodulation: The Next Novel Therapeutic Approach in Overcoming Ischemic Stroke? Open
The immune response following neuroinflammation is a vital element of ischemic stroke pathophysiology. After the onset of ischemic stroke, a specialized vasculature system that effectively protects central nervous system tissues from the i…
View article: Adiponectin: The Potential Regulator and Therapeutic Target of Obesity and Alzheimer’s Disease
Adiponectin: The Potential Regulator and Therapeutic Target of Obesity and Alzheimer’s Disease Open
Animal and human mechanistic studies have consistently shown an association between obesity and Alzheimer’s disease (AD). AD, a degenerative brain disease, is the most common cause of dementia and is characterized by the presence of extrac…
View article: Heat Shock Protein 70 (HSP70) Induction: Chaperonotherapy for Neuroprotection after Brain Injury
Heat Shock Protein 70 (HSP70) Induction: Chaperonotherapy for Neuroprotection after Brain Injury Open
The 70 kDa heat shock protein (HSP70) is a stress-inducible protein that has been shown to protect the brain from various nervous system injuries. It allows cells to withstand potentially lethal insults through its chaperone functions. Its…