Hee‐Won Jung
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View article: Association Between Serum Ferritin Levels and Frailty Risk in Community-Dwelling Older Adults: A Nationwide Population-Based Study
Association Between Serum Ferritin Levels and Frailty Risk in Community-Dwelling Older Adults: A Nationwide Population-Based Study Open
Background Ferritin is a key iron storage protein and a marker of iron metabolism, linked to various health outcomes beyond hematologic conditions. This study examined the association between serum ferritin levels and the frailty index (FI…
View article: Comprehensive approaches to diabetes in the elderly: adapting to evolving trends
Comprehensive approaches to diabetes in the elderly: adapting to evolving trends Open
Background/Aims: The prevalence of diabetes mellitus (DM) is increasing worldwide owing to aging. This nationwide study aimed to investigate the prevalence of DM and its management status among elderly Koreans.Methods: We analyzed data fro…
View article: Effect of a multicomponent intervention on institutionalization-free survival in older adults with sarcopenia: a post-hoc analysis
Effect of a multicomponent intervention on institutionalization-free survival in older adults with sarcopenia: a post-hoc analysis Open
Objectives To assess the effect of a 24-week comprehensive multicomponent intervention on institutionalization-free survival, physical performance, and frailty among older adults with sarcopenia. Design A post-hoc analysis of a prospective…
View article: Acute Care for Elders Risk Score: A Practical Machine Learning–Based Tool for Screening High-Risk Older Inpatients
Acute Care for Elders Risk Score: A Practical Machine Learning–Based Tool for Screening High-Risk Older Inpatients Open
The ACE Risk Score is a practical, interpretable, and scalable tool for early identification of high-risk older inpatients, using data available on the first day of admission. It supports timely, targeted interventions by geriatric teams. …
View article: Impact of a prolonged nationwide residents’ strike on acute ischemic stroke care in a metropolitan city
Impact of a prolonged nationwide residents’ strike on acute ischemic stroke care in a metropolitan city Open
BackgroundAcute ischemic stroke (AIS) requires timely management in both prehospital and in-hospital phases to optimize outcomes. In 2024, South Korea experienced a prolonged nationwide residents’ strike that disrupted the healthcare syste…
View article: Standardized Measurement of Muscle Strength and Physical Performance for Sarcopenia: An Expert-Based Delphi Consensus
Standardized Measurement of Muscle Strength and Physical Performance for Sarcopenia: An Expert-Based Delphi Consensus Open
Background: Despite updated sarcopenia guidelines, inconsistent protocols still cause clinical confusion and may compromise diagnostic and outcome accuracy. This Delphi study aimed to establish expert consensus to support the standardizati…
View article: Detrimental Effects of β2‐Microglobulin on Muscle Metabolism: Evidence From In Vitro, Animal and Human Research
Detrimental Effects of β2‐Microglobulin on Muscle Metabolism: Evidence From In Vitro, Animal and Human Research Open
Background β2‐Microglobulin (B2M) has garnered considerable interest as a potential pro‐ageing factor, leading to speculation about its involvement in muscle metabolism and the development of sarcopenia, a key component of ageing phenotype…
View article: The U-Shaped Association Between Serum Ferritin Levels and Frailty Risk in Older Adults: A Nationwide Population-Based Study (Preprint)
The U-Shaped Association Between Serum Ferritin Levels and Frailty Risk in Older Adults: A Nationwide Population-Based Study (Preprint) Open
BACKGROUND Ferritin, a key iron storage protein in the body, acts as an essential indicator of iron metabolism and is involved in various health conditions beyond hematologic disorders. Clinical evidence suggests that both elevated and re…
View article: Higher serum resistin levels and increased frailty risk in older adults: Implications beyond metabolic function
Higher serum resistin levels and increased frailty risk in older adults: Implications beyond metabolic function Open
These findings suggest that circulating resistin may serve as a candidate blood-based biomarker for frailty, encompassing the multifaceted physical, cognitive, and social dimensions, extending beyond its well-established role in metabolic …
View article: Effect of Exercise and Nutrition Intervention for Older Adults with Impaired Physical Function with Preserved Muscle Mass (Functional Sarcopenia): A Randomized Controlled Trial
Effect of Exercise and Nutrition Intervention for Older Adults with Impaired Physical Function with Preserved Muscle Mass (Functional Sarcopenia): A Randomized Controlled Trial Open
The 12-week exercise and nutritional intervention significantly enhanced physical performance, grip strength, and quality of life among community-dwelling older adults with functional sarcopenia. This suggests that strategies commonly reco…
View article: Circulating apelin levels fail to link sarcopenia-related muscle parameters in older adults
Circulating apelin levels fail to link sarcopenia-related muscle parameters in older adults Open
These findings suggest that, contrary to previous studies in cellular and animal models where apelin demonstrated a protective impact on muscle homeostasis, such effects may not translate to the human context, and contribute valuable clini…
View article: Exploring the Barriers and Facilitators of Deprescribing in Older Adults: Qualitative Study of Patients and Geriatrics Experts
Exploring the Barriers and Facilitators of Deprescribing in Older Adults: Qualitative Study of Patients and Geriatrics Experts Open
Addressing barriers to deprescribing in South Korea requires a multifaceted approach, including public awareness campaigns, healthcare provider education, prescription sharing systems, and a geriatric primary care system. Long-term policie…
View article: Elevated Serum IL-6 as a Negative Prognostic Biomarker in Glioblastoma: Integrating Bioinformatics and Clinical Validation
Elevated Serum IL-6 as a Negative Prognostic Biomarker in Glioblastoma: Integrating Bioinformatics and Clinical Validation Open
Background: Glioblastoma multiforme (GBM) is the most lethal type of primary brain tumor, necessitating the discovery of reliable serum prognostic biomarkers. This study aimed to investigate the prognostic value of serum Interleukin…
View article: Circulating BMP-7 Level is Independent of Sarcopenia in Older Asian Adults
Circulating BMP-7 Level is Independent of Sarcopenia in Older Asian Adults Open
Background: In vitro and animal studies have demonstrated that bone morphogenetic protein-7 (BMP-7), renowned for its osteogenic properties, also exerts beneficial effects on muscle metabolism by enhancing myogenesis and reversing muscle a…
View article: Elevated Circulating Sclerostin Levels in Frail Older Adults: Implications beyond Bone Health
Elevated Circulating Sclerostin Levels in Frail Older Adults: Implications beyond Bone Health Open
Background: Sclerostin, initially recognized for its pivotal role in bone metabolism, has gained attention for its multifaceted impact on overall human health. However, its influence on frailty—a condition that best reflects biological age…
View article: Higher serum uric acid as a risk factor for frailty in older adults: A nationwide population‐based study
Higher serum uric acid as a risk factor for frailty in older adults: A nationwide population‐based study Open
Background Uric acid (UA), the terminal breakdown product of purine metabolism, possesses contradictory roles, functioning both as an inflammatory mediator and as an antioxidant. Its clinical relevance, particularly in geriatric population…
View article: Machine learning model reveals roles of interferon‑stimulated genes in sorafenib‑resistant liver cancer
Machine learning model reveals roles of interferon‑stimulated genes in sorafenib‑resistant liver cancer Open
HCC (Hepatocellular carcinoma) is the most common malignant tumor; however, the molecular pathogenesis of these tumors is not well understood. Sorafenib, an approved treatment for HCC, inhibits angiogenesis and tumor cell proliferation. Ho…
View article: A Study on the Muscle Strengthening Properties of High-Protein Texture-Modified Foods (HPTMF) in Elderly Patients With Clinical Frailty
A Study on the Muscle Strengthening Properties of High-Protein Texture-Modified Foods (HPTMF) in Elderly Patients With Clinical Frailty Open
View article: Comparative Analysis of Gait Speed Measurement Protocols: Static Start Versus Dynamic Start in a Cross-Sectional Study Using Light Detection and Ranging
Comparative Analysis of Gait Speed Measurement Protocols: Static Start Versus Dynamic Start in a Cross-Sectional Study Using Light Detection and Ranging Open
Static start underestimates gait speed, while dynamic start aligns better with other physical performance results. An acceleration phase of 0.5 to 1 meter appears sufficient, but further studies are needed to optimize gait measurement meth…
View article: Sarcopenia as the Mobility Phenotype of Aging: Clinical Implications
Sarcopenia as the Mobility Phenotype of Aging: Clinical Implications Open
Sarcopenia, which is characterized by an age-related decline in muscle mass and function, poses significant challenges to geriatric care. Its definition has evolved from muscle-specific criteria to include muscle mass, muscle function, and…
View article: Comparison of anticholinergic burden with chronic polypharmacy on functional decline and mortality in Korean older people: a retrospective nationwide cohort study
Comparison of anticholinergic burden with chronic polypharmacy on functional decline and mortality in Korean older people: a retrospective nationwide cohort study Open
Background We aimed to evaluate the association of anticholinergic burden and chronic polypharmacy with the incidence of functional decline and all-cause mortality, and to determine the difference between anticholinergic burden and chronic…
View article: Future Blood Debt: Projecting Blood Supply and Demand of Korea Based on Subnational Population Projections (2021–2050)
Future Blood Debt: Projecting Blood Supply and Demand of Korea Based on Subnational Population Projections (2021–2050) Open
The findings emphasize the urgent need for targeted strategies to mitigate national and regional blood supply shortages in South Korea. Encouraging frequent donations from experienced donors and broadening eligibility criteria are critical…
View article: Geriatric Medicine in South Korea: A Stagnant Reality amidst an Aging Population
Geriatric Medicine in South Korea: A Stagnant Reality amidst an Aging Population Open
In the face of an ever-increasing wave of an aging population, this paper provides an update on the current status of geriatric medicine in Korea, comparing it with global initiatives and suggesting future directions. Older adults require …
View article: Neurocritical Care Nutrition: Unique Considerations and Strategies for Optimizing Energy Supply and Metabolic Support in Critically Ill Patients
Neurocritical Care Nutrition: Unique Considerations and Strategies for Optimizing Energy Supply and Metabolic Support in Critically Ill Patients Open
Neuro-critically ill patients face unique challenges in nutritional support due to varying metabolic and energy demands arising from clinical situations such as elevated intracranial pressure, trauma, stroke, epilepsy, targeted temperature…
View article: Higher Plasma Stromal Cell-Derived Factor 1 Is Associated with Lower Risk for Sarcopenia in Older Asian Adults
Higher Plasma Stromal Cell-Derived Factor 1 Is Associated with Lower Risk for Sarcopenia in Older Asian Adults Open
Background: Despite the protective effects of stromal cell-derived factor 1 (SDF-1) in stimulating muscle regeneration shown in experimental research, there is a lack of clinical studies linking circulating SDF-1 concentrations with muscle…
View article: Unmet Needs and Barriers in Providing Hospital Care for Older Adults: A Qualitative Study Using the Age-Friendly Health System Framework
Unmet Needs and Barriers in Providing Hospital Care for Older Adults: A Qualitative Study Using the Age-Friendly Health System Framework Open
The study highlighted the need for improvements in inpatient care for older adults at an academic hospital in Korea. Identified unmet needs and barriers can be used to guide a more patient-centered approaches for an age-friendly inpatient …
View article: The Clinical Frailty Scale as a Risk Assessment Tool for Dysphagia in Older Inpatients: A Cross-Sectional Study
The Clinical Frailty Scale as a Risk Assessment Tool for Dysphagia in Older Inpatients: A Cross-Sectional Study Open
Background: Dysphagia is a common problem with potentially serious consequences including malnutrition, dehydration, pneumonia, and death. However, there are challenges in screening for dysphagia in older adults. We assessed the feasibilit…
View article: Associations of social interactions during the COVID-19 pandemic with cognitive function among the South Korean older adults
Associations of social interactions during the COVID-19 pandemic with cognitive function among the South Korean older adults Open
View article: Comparative Study of the Accuracy of At-Point Clinical Frailty Scale and Morse Fall Scale in Identifying High-Risk Fall Patients among Hospitalized Adults
Comparative Study of the Accuracy of At-Point Clinical Frailty Scale and Morse Fall Scale in Identifying High-Risk Fall Patients among Hospitalized Adults Open
Background: Falls are a major concern among hospitalized adults, and it is essential to identify high-risk patients to prevent falls. This retrospective cohort study conducted at the Asan Medical Center, Korea, compared the screening abili…
View article: Lack of association between serum myonectin levels and sarcopenia in older Asian adults
Lack of association between serum myonectin levels and sarcopenia in older Asian adults Open
Myonectin is a muscle-secreted factor that helps maintain homeostasis in the body by regulating several functions, including lipid metabolism. Previous studies suggested that myonectin may play a role in muscle health in an autocrine manne…