Joo Sang Lee
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View article: AIM2 drives inflammatory cell death and monkeypox pathogenesis
AIM2 drives inflammatory cell death and monkeypox pathogenesis Open
Monkeypox, a zoonotic disease caused by the monkeypox virus (MPXV), has significant global public health implications. Inflammasomes serve as crucial components of the innate immune system, detecting pathogens and triggering cell death in …
View article: Prolonged immune activation in post-acute sequelae of SARS-CoV-2: neutrophil dynamics and therapeutic insights
Prolonged immune activation in post-acute sequelae of SARS-CoV-2: neutrophil dynamics and therapeutic insights Open
View article: Can the tumor neural niche be targeted to re-program cancer?
Can the tumor neural niche be targeted to re-program cancer? Open
Interactions between the peripheral nervous system and solid tumors influence cancer progression and treatment response. Defining the 3D tumor neural niche using spatial omics and AI technologies will identify new opportunities for targete…
View article: Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality
Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality Open
View article: Kinetic organization of the genome revealed by ultra-resolution, multiscale live imaging
Kinetic organization of the genome revealed by ultra-resolution, multiscale live imaging Open
In the last decade, sequencing methods like Hi-C have made it clear the genome is intricately folded, and that this organization contributes significantly to the control of gene expression and thence cell fate and behavior. Single-cell DNA…
View article: Supplementary Figure S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S2 demonstrates the infiltration of mature innate immune cells to the liver during breast carcinogenesis
View article: Supplementary Table S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S4 lists the antibodies used for FACS
View article: Supplementary Table S5 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S5 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S5 lists the antibodies used for CyTOF
View article: Supplementary Figure S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S3 shows that targeting the IL-6-pSTAT-HNF4a pathway preserves liver metabolism and restricts BC growth
View article: Supplementary Figure S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S2 demonstrates the infiltration of mature innate immune cells to the liver during breast carcinogenesis
View article: Supplementary Extended Data 1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Extended Data 1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Extended Data 1 describes the FACS gating startegy
View article: Supplementary Table S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S4 lists the antibodies used for FACS
View article: Supplementary Figure S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S1 demonstrates global metabolic changes in liver metabolism during early BC carcinogenesis
View article: Supplementary Table S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S3 lists the primers used for qPCR
View article: Supplementary Table S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S2 lists the antibodies used for western blots
View article: Supplementary Table S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S3 lists the primers used for qPCR
View article: Supplementary Figure S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S3 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S3 shows that targeting the IL-6-pSTAT-HNF4a pathway preserves liver metabolism and restricts BC growth
View article: Supplementary Table S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S1 details clinical data of PDAC patients
View article: Supplementary Table S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S1 details clinical data of PDAC patients
View article: Supplementary Extended Data 1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Extended Data 1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Extended Data 1 describes the FACS gating startegy
View article: Supplementary Figure S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S4 demonstrates similar transcriptional and metabolic changes following liver infiltration of immune cells to the liver of PDAC mice
View article: Supplementary Figure S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S4 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S4 demonstrates similar transcriptional and metabolic changes following liver infiltration of immune cells to the liver of PDAC mice
View article: Supplementary Table S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S2 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S2 lists the antibodies used for western blots
View article: Supplementary Figure S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S1 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S1 demonstrates global metabolic changes in liver metabolism during early BC carcinogenesis
View article: Supplementary Table S5 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S5 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S5 lists the antibodies used for CyTOF
View article: Supplementary Figure S5 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S5 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S5 demonstrate the significance of our liver score in predicting outcomes of BC and PDAC patients
View article: Supplementary Figure S5 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Figure S5 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Figure S5 demonstrate the significance of our liver score in predicting outcomes of BC and PDAC patients
View article: Supplementary Table S6 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S6 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S6 lists the genes regulated by HNF4a
View article: Supplementary Table S6 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis
Supplementary Table S6 from Early infiltration of innate immune cells to the liver depletes HNF4a and promotes extra-hepatic carcinogenesis Open
Supplementary Table S6 lists the genes regulated by HNF4a
View article: Identification of intracellular bacteria from multiple single-cell RNA-seq platforms using CSI-Microbes
Identification of intracellular bacteria from multiple single-cell RNA-seq platforms using CSI-Microbes Open
The study of the tumor microbiome has been garnering increased attention. We developed a computational pipeline (CSI-Microbes) for identifying microbial reads from single-cell RNA sequencing (scRNA-seq) data and for analyzing differential …