Joohan Woo
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View article: Therapeutic effects of Poncirus fructus on colonic dysfunction and visceral pain in a zymosan-induced irritable bowel syndrome mouse model through interstitial cells of Cajal and ion channel modulation
Therapeutic effects of Poncirus fructus on colonic dysfunction and visceral pain in a zymosan-induced irritable bowel syndrome mouse model through interstitial cells of Cajal and ion channel modulation Open
Purpose Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder with few effective long-term treatments. This study investigated the therapeutic potential of Poncirus fructus extract (PFE) for IBS-like symptoms, focusing on…
View article: Polypharmacological effects of honokiol on allergic rhinitis: Modulation of TMEM16A, TRPV1, and calcium signaling
Polypharmacological effects of honokiol on allergic rhinitis: Modulation of TMEM16A, TRPV1, and calcium signaling Open
Our findings revealed that the therapeutic effect of honokiol stems from its novel polypharmacological action on multiple ion channels and critical immune cells. By suppressing both early- (mast cell-driven) and late-phase (T cell-driven) …
View article: Vitexicarpin suppresses colorectal and non-small cell lung cancer via selective inhibition of Anoctamin 1
Vitexicarpin suppresses colorectal and non-small cell lung cancer via selective inhibition of Anoctamin 1 Open
Colorectal cancer (CRC) and non-small cell lung cancer (NSCLC) remain among the most challenging malignancies to treat due to therapy complexity, adverse events, and dose-limiting toxicities, which often result in treatment failure. NSCLC,…
View article: Structure-based identification of potent modulators from Centella asiatica targeting BACE-1
Structure-based identification of potent modulators from Centella asiatica targeting BACE-1 Open
β-secretase enzyme 1 or BACE-1 is attributed to generating Aβ plaques, a key pathological feature of Alzheimer's disease (AD)-associated dementia, and is an attractive target for AD management. Due to acute side effects and toxicity, some …
View article: Requirement of β subunit for the reduced voltage-gated Na<sup>+</sup> current of a Brugada syndrome patient having novel double missense mutation (p.A385T/R504T) of <i>SCN5A</i>
Requirement of β subunit for the reduced voltage-gated Na<sup>+</sup> current of a Brugada syndrome patient having novel double missense mutation (p.A385T/R504T) of <i>SCN5A</i> Open
Mutations within the SCN5A gene, which encodes the α-subunit 5 (NaV1.5) of the voltage-gated Na+ channel, have been linked to three distinct cardiac arrhythmia disorders: long QT syndrome type 3, Brugada syndrome (BrS), and cardiac conduct…
View article: Atractylodes macrocephala Koidz Alleviates Symptoms in Zymosan-Induced Irritable Bowel Syndrome Mouse Model through TRPV1, NaV1.5, and NaV1.7 Channel Modulation
Atractylodes macrocephala Koidz Alleviates Symptoms in Zymosan-Induced Irritable Bowel Syndrome Mouse Model through TRPV1, NaV1.5, and NaV1.7 Channel Modulation Open
(1) Background: Irritable bowel syndrome (IBS) is a common disease in the gastrointestinal (GI) tract. Atractylodes macrocephala Koidz (AMK) is known as one of the traditional medicines that shows a good efficacy in the GI tract. (2) Metho…
View article: Identifying the Multitarget Pharmacological Mechanism of Action of Genistein on Lung Cancer by Integrating Network Pharmacology and Molecular Dynamic Simulation
Identifying the Multitarget Pharmacological Mechanism of Action of Genistein on Lung Cancer by Integrating Network Pharmacology and Molecular Dynamic Simulation Open
Food supplements have become beneficial as adjuvant therapies for many chronic disorders, including cancer. Genistein, a natural isoflavone enriched in soybeans, has gained potential interest as an anticancer agent for various cancers, pri…
View article: Discovery of a novel natural compound, vitekwangin B, with ANO1 protein reduction properties and anticancer potential
Discovery of a novel natural compound, vitekwangin B, with ANO1 protein reduction properties and anticancer potential Open
Background: Prostate cancer and non-small cell lung cancer (NSCLC) present significant challenges in the development of effective therapeutic strategies. Hormone therapies for prostate cancer target androgen receptors and prostate-specific…
View article: Anticancer Effect of Verteporfin on Non-Small Cell Lung Cancer via Gradual Reduction of ANO1 Protein Levels
Anticancer Effect of Verteporfin on Non-Small Cell Lung Cancer via Gradual Reduction of ANO1 Protein Levels Open
Background and Purpose: Anoctamin 1 (ANO1) is a calcium-activated chloride channel found in various cell types and is overexpressed in non-small cell lung cancer (NSCLC), a major cause of cancer-related mortality. This study aimed to inves…
View article: Methanol Extract of <i>Petasites japonicus</i> Promotes Apoptosis via the MAPK and ROS-dependent Signaling Pathways
Methanol Extract of <i>Petasites japonicus</i> Promotes Apoptosis via the MAPK and ROS-dependent Signaling Pathways Open
Background: Petasites japonicus (PJ), also known as Butterbur, has a rich history as a traditional healing remedy across numerous countries. Objectives: This study was designed to evaluate the potential anti-cancer properties of the methan…
View article: Translation reinitiation in c.453delC frameshift mutation of <i>KCNH2</i> producing functional hERG K+ channels with mild dominant negative effect in the heterozygote patient-derived iPSC cardiomyocytes
Translation reinitiation in c.453delC frameshift mutation of <i>KCNH2</i> producing functional hERG K+ channels with mild dominant negative effect in the heterozygote patient-derived iPSC cardiomyocytes Open
The c.453delC (p.Thr152Profs*14) frameshift mutation in KCNH2 is associated with an elevated risk of Long QT syndrome (LQTS) and fatal arrhythmia. Nevertheless, the loss-of-function mechanism underlying this mutation remains unexplored and…
View article: ANO1-downregulation induced by schisandrathera D: a novel therapeutic target for the treatment of prostate and oral cancers
ANO1-downregulation induced by schisandrathera D: a novel therapeutic target for the treatment of prostate and oral cancers Open
Anoctamin 1 (ANO1), a drug target for various cancers, including prostate and oral cancers, is an intracellular calcium-activated chloride ion channel that plays various physiopathological roles, especially in the induction of cancer growt…
View article: Unveiling the Potentiality of Shikonin Derivatives Inhibiting SARS-CoV-2 Main Protease by Molecular Dynamic Simulation Studies
Unveiling the Potentiality of Shikonin Derivatives Inhibiting SARS-CoV-2 Main Protease by Molecular Dynamic Simulation Studies Open
Shikonin, a phytochemical present in the roots of Lithospermum erythrorhizon, is well-known for its broad-spectrum activity against cancer, oxidative stress, inflammation, viruses, and anti-COVID-19 agents. A recent report based on a cryst…
View article: Binding mechanisms of Shikonin derivatives targeting SARS‐CoV‐2 main protease
Binding mechanisms of Shikonin derivatives targeting SARS‐CoV‐2 main protease Open
Shikonin, a well‐known bioactive chemical present in the dried roots of Lithospermum erthrorhizon, is recognized for its broad‐spectrum activities against cancer, oxidative stress, inflammation, virus, and anti‐COVID‐19 agent. In recent di…
View article: Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling
Lower troponin expression in the right ventricle of rats explains interventricular differences in E–C coupling Open
Despite distinctive functional and anatomic differences, a precise understanding of the cardiac interventricular differences in excitation–contraction (E–C) coupling mechanisms is still lacking. Here, we directly compared rat right and lef…
View article: [6]-Gingerol induces Caspase-Dependent Apoptosis in Bladder Cancer cells via MAPK and ROS Signaling
[6]-Gingerol induces Caspase-Dependent Apoptosis in Bladder Cancer cells via MAPK and ROS Signaling Open
The anti-cancer effects of [6]-gingerol ([6]-GIN), the main active polyphenol of ginger (Zingiber officinale), were investigated in the human bladder cancer cell line 5637. [6]-GIN inhibited cell proliferation, increased sub‑G1 phase ratio…
View article: Dual Mechanisms of Cardiac Action Potential Prolongation by 4-Oxo-Nonenal Increasing the Risk of Arrhythmia; Late Na+ Current Induction and hERG K+ Channel Inhibition
Dual Mechanisms of Cardiac Action Potential Prolongation by 4-Oxo-Nonenal Increasing the Risk of Arrhythmia; Late Na+ Current Induction and hERG K+ Channel Inhibition Open
4-Oxo-nonenal (4-ONE) is an endogenous lipid peroxidation product that is more reactive than 4-hydroxy-nonenal (4-HNE). We previously reported the arrhythmic potential of 4-HNE by suppression of cardiac human Ether-a-go-go Related Gene (hE…
View article: Diethylstilbestrol, a Novel ANO1 Inhibitor, Exerts an Anticancer Effect on Non-Small Cell Lung Cancer via Inhibition of ANO1
Diethylstilbestrol, a Novel ANO1 Inhibitor, Exerts an Anticancer Effect on Non-Small Cell Lung Cancer via Inhibition of ANO1 Open
Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related mortality; thus, therapeutic targets continue to be developed. Anoctamin1 (ANO1), a novel drug target considered for the treatment of NSCLC, is a Ca2+-activa…
View article: Nootkatol prevents ultraviolet radiation-induced photoaging <i>via</i> ORAI1 and TRPV1 inhibition in melanocytes and keratinocytes
Nootkatol prevents ultraviolet radiation-induced photoaging <i>via</i> ORAI1 and TRPV1 inhibition in melanocytes and keratinocytes Open
Skin photoaging occurs due to chronic exposure to solar ultraviolet radiation (UV), the main factor contributing to extrinsic skin aging. Clinical signs of photoaging include the formation of deep, coarse skin wrinkles and hyperpigmentatio…
View article: Dual regulatory effects of PI(4,5)P<sub>2</sub> on TREK-2 K<sup>+</sup> channel through antagonizing interaction between the alkaline residues (K<sup>330</sup> and R<sup>355-357</sup>) in the cytosolic C-terminal helix
Dual regulatory effects of PI(4,5)P<sub>2</sub> on TREK-2 K<sup>+</sup> channel through antagonizing interaction between the alkaline residues (K<sup>330</sup> and R<sup>355-357</sup>) in the cytosolic C-terminal helix Open
TWIK-related two-pore domain K+ channel-2 (TREK-2) has voltageindependent activity and shows additional activation by acidic intracellular pH (pHi) via neutralizing the E332 in the cytoplasmic C terminal (Ct). We reported opposite regulati…
View article: The agonistic action of URO-K10 on Kv7.4 and 7.5 channels is attenuated by co-expression of KCNE4 ancillary subunit
The agonistic action of URO-K10 on Kv7.4 and 7.5 channels is attenuated by co-expression of KCNE4 ancillary subunit Open
KCNQ family constitutes slowly-activating potassium channels among voltage-gated potassium channel superfamily. Recent studies suggested that KCNQ4 and 5 channels are abundantly expressed in smooth muscle cells, especially in lower urinary…
View article: Thermosensitivity of the voltage-dependent activation of calcium homeostasis modulator 1 (calhm1) ion channel
Thermosensitivity of the voltage-dependent activation of calcium homeostasis modulator 1 (calhm1) ion channel Open
Calcium homeostasis modulator 1 (calhm1) proteins form an outwardly rectifying nonselective ion channel having exceedingly slow kinetics and low sensitivity to voltage that is shifted by lowering extracellular Ca 2+ ([Ca 2+ ] e ). Here we …
View article: Luteolin reduces fluid hypersecretion by inhibiting TMEM16A in interleukin-4 treated Calu-3 airway epithelial cells
Luteolin reduces fluid hypersecretion by inhibiting TMEM16A in interleukin-4 treated Calu-3 airway epithelial cells Open
Rhinorrhea in allergic rhinitis (AR) is characterized by the secretion of electrolytes in the nasal discharge. The secretion of Cl- and HCO3- is mainly regulated by cystic fibrosis transmembrane conductance regulator (CFTR) or via the calc…
View article: <i>Gardenia jasminoides</i> extract and its constituent, genipin, inhibit activation of CD3/CD28 co-stimulated CD4<sup>+</sup> T cells <i>via</i> ORAI1 channel
<i>Gardenia jasminoides</i> extract and its constituent, genipin, inhibit activation of CD3/CD28 co-stimulated CD4<sup>+</sup> T cells <i>via</i> ORAI1 channel Open
Gardenia jasminoides (GJ) is a widely used herbal medicine with antiinflammatory properties, but its effects on the ORAI1 channel, which is important in generating intracellular calcium signaling for T cell activation, remain unknown. In t…
View article: Teaching cardiac excitation-contraction coupling using a mathematical computer simulation model of human ventricular myocytes
Teaching cardiac excitation-contraction coupling using a mathematical computer simulation model of human ventricular myocytes Open
To understand the excitation-contraction (E-C) coupling of cardiomyocytes, including the electrophysiological mechanism of their characteristically long action potential duration, is one of the major learning goals in medical physiology. H…
View article: Triple arginine residues in the proximal C-terminus of TREK K<sup>+</sup> channels are critical for biphasic regulation by phosphatidylinositol 4,5-bisphosphate
Triple arginine residues in the proximal C-terminus of TREK K<sup>+</sup> channels are critical for biphasic regulation by phosphatidylinositol 4,5-bisphosphate Open
TWIK-related two-pore domain K + channels (TREKs) are activated by acidic intracellular pH (pH i ), membrane stretch, temperature, and arachidonic acid (AA). Phosphatidylinositol 4,5-bisphosphate (PIP 2 ) exerts concentration-dependent bip…
View article: EP02.06: Umbilical artery Doppler study at 28–30 weeks of gestation as a predictive marker of adverse pregnancy outcomes
EP02.06: Umbilical artery Doppler study at 28–30 weeks of gestation as a predictive marker of adverse pregnancy outcomes Open
To evaluate the clinical utility of umbilical artery Doppler study in early third trimester scan for predicting adverse perinatal outcomes. A total of 102 patients with singleton pregnancies who received antenatal umbilical artery Doppler …