Beom Joon Kim
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View article: Differential Effects of Admission Hemoglobin A <sub>1c</sub> by Estimated Glomerular Filtration Rate Stages on Mortality in Acute Ischemic Stroke and Diabetes
Differential Effects of Admission Hemoglobin A <sub>1c</sub> by Estimated Glomerular Filtration Rate Stages on Mortality in Acute Ischemic Stroke and Diabetes Open
Background The relationship between admission hemoglobin A 1c (HbA 1c ) levels, estimated glomerular filtration rate (eGFR) stages, and early outcomes may provide key insights into the need for individualized glycemic control based on kidn…
View article: Extending Dual Antiplatelet Therapy Beyond 3 Months in Acute Ischemic Stroke Due to Large‐Artery Atherosclerosis
Extending Dual Antiplatelet Therapy Beyond 3 Months in Acute Ischemic Stroke Due to Large‐Artery Atherosclerosis Open
Background The optimal duration of dual antiplatelet therapy (DAPT) with aspirin plus clopidogrel following acute ischemic stroke due to large‐artery atherosclerosis remains uncertain. Methods We retrospectively analyzed data from a prospe…
View article: Pea Sprout Extract Promotes Hair Follicle Regeneration via Anagen Phase Prolongation and Dual Modulation of Oxidative and Inflammatory Signaling
Pea Sprout Extract Promotes Hair Follicle Regeneration via Anagen Phase Prolongation and Dual Modulation of Oxidative and Inflammatory Signaling Open
Hair loss is a prevalent condition that affects individuals across all ages and genders. Its causes are multifactorial, involving genetic predisposition, hormonal imbalances, aging, stress and air pollution factors. A previous randomized c…
View article: Supracardiac Atherosclerotic Lesions in Embolic Stroke of Undetermined Source: Predicting Stroke Recurrence and Enhancing Secondary Prevention Strategies
Supracardiac Atherosclerotic Lesions in Embolic Stroke of Undetermined Source: Predicting Stroke Recurrence and Enhancing Secondary Prevention Strategies Open
Background Identifying the potential cause of embolic stroke of undetermined source is essential for secondary prevention. We analyzed retrospectively collected real‐world data from the South Korean cohort with embolic stroke of undetermin…
View article: Comparative validation of automated perfusion analysis software for ischemic penumbra estimation and EVT decision-making
Comparative validation of automated perfusion analysis software for ischemic penumbra estimation and EVT decision-making Open
Background While computed tomography perfusion is widely used in acute stroke imaging, magnetic resonance perfusion-weighted imaging (PWI) offers superior spatial resolution and tissue specificity, particularly when combined with diffusion…
View article: Safety and efficacy of trans esophageal echocardiography using flexible over-tube: multicenter pilot study
Safety and efficacy of trans esophageal echocardiography using flexible over-tube: multicenter pilot study Open
Background A recent review article reported that gastrointestinal complications related to transesophageal echocardiography (TEE)—including visceral perforations, mucosal damage, bleeding, and persistent odynophagia—occur in up to 28% of c…
View article: Distinct spatiotemporal patterns of white matter hyperintensity progression
Distinct spatiotemporal patterns of white matter hyperintensity progression Open
White matter hyperintensity, a key imaging biomarker for brain health, has prognostic implications for stroke. Using a multicenter MRI dataset of 9179 stroke patients plus the UK Biobank (n = 36,210 low/high risk controls), we employ Subty…
View article: Reviewer Comment on Almekhlafi et al. “Adjunctive Intraarterial Thrombolysis after Thrombectomy in Large Vessel Occlusion Stroke: A Meta-Analysis of RCTs”
Reviewer Comment on Almekhlafi et al. “Adjunctive Intraarterial Thrombolysis after Thrombectomy in Large Vessel Occlusion Stroke: A Meta-Analysis of RCTs” Open
View article: Effect of atorvastatin versus no Statin Treatment on major clinical events in Acute CardioEmbolic stroke patients without a definite indication for statin therapy: protocol for the STACE trial
Effect of atorvastatin versus no Statin Treatment on major clinical events in Acute CardioEmbolic stroke patients without a definite indication for statin therapy: protocol for the STACE trial Open
View article: Varying Rates of Hospital Reperfusion Therapy for Stroke: Insights From Analysis of National Stroke Audit Data
Varying Rates of Hospital Reperfusion Therapy for Stroke: Insights From Analysis of National Stroke Audit Data Open
Background and Purpose Disparities in stroke care exist globally. While reperfusion therapy is a standard treatment for acute ischemic stroke, variations in its implementation may exist across hospitals.Methods We analyzed data from 75,870…
View article: Deep Learning–Based Automatic Classification of Stroke Size in Patients With Atrial Fibrillation
Deep Learning–Based Automatic Classification of Stroke Size in Patients With Atrial Fibrillation Open
View article: Automated ischemic stroke lesion detection on non-contrast brain CT: a large-scale clinical feasibility test AI stroke lesion detection on NCCT
Automated ischemic stroke lesion detection on non-contrast brain CT: a large-scale clinical feasibility test AI stroke lesion detection on NCCT Open
Background Non-contrast CT (NCCT) is widely used imaging modality for acute stroke imaging but often fails to detect subtle early ischemic changes. Such underestimation can lead clinicians to overlook tissue-level information. This study a…
View article: Timing of Initiation and Efficacy of Dual Antiplatelet Therapy in Minor Stroke or High-Risk TIA
Timing of Initiation and Efficacy of Dual Antiplatelet Therapy in Minor Stroke or High-Risk TIA Open
Background Dual antiplatelet therapy (DAPT) with aspirin and clopidogrel is recommended within 24 hours for patients with minor ischemic stroke or high-risk transient ischemic attack (TIA). However, the optimal timing for initiating DAPT i…
View article: Temporal Patterns of Antithrombotic Therapy and Clinical Outcomes After Atrial Fibrillation-Related Stroke
Temporal Patterns of Antithrombotic Therapy and Clinical Outcomes After Atrial Fibrillation-Related Stroke Open
Background There is clinical equipoise in relation to the optimal timing and strategy for antithrombotic therapy in acute ischemic stroke (AIS) patients with atrial fibrillation (AF) who may be eligible for non-vitamin K antagonist oral an…
View article: Multicenter Validation of Artificial Intelligence Predicting Anterior Circulation Large Vessel Occlusion Using Noncontrast Head CT
Multicenter Validation of Artificial Intelligence Predicting Anterior Circulation Large Vessel Occlusion Using Noncontrast Head CT Open
Background To validate an artificial intelligence software (JLK CTL) for predicting anterior circulation large vessel occlusion (LVO) using noncontrast computed tomography (NCCT) and to investigate its clinical implications regarding both …
View article: Deep learning to identify stroke within 4.5 h using DWI and FLAIR in a prospective multicenter study
Deep learning to identify stroke within 4.5 h using DWI and FLAIR in a prospective multicenter study Open
To enhance thrombolysis eligibility in acute ischemic stroke, we developed a deep learning model to estimate stroke onset within 4.5 h using diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR) images. Given the…
View article: Isokinetic muscle function, dynamic balance, and injury risk in dominant and non-dominant lower extremities of adolescent taekwondo athletes
Isokinetic muscle function, dynamic balance, and injury risk in dominant and non-dominant lower extremities of adolescent taekwondo athletes Open
Background Adolescent Taekwondo athletes are exposed to distinct musculoskeletal demands, where imbalances in muscle function and deficiencies in dynamic balance may increase their risk of injury. Objective This study aimed to assess the e…
View article: Efficacy and Safety of <scp>CKDB</scp>‐<scp>501A</scp> in Treating Moderate‐To‐Severe Glabellar Lines: A Randomized, Double‐Blind, Active‐Controlled, Multi‐Center Phase <scp>III</scp> Trial
Efficacy and Safety of <span>CKDB</span>‐<span>501A</span> in Treating Moderate‐To‐Severe Glabellar Lines: A Randomized, Double‐Blind, Active‐Controlled, Multi‐Center Phase <span>III</span> Trial Open
Background Botulinum toxin is a key treatment for dynamic wrinkles. Objective This study evaluates CKDB‐501A, a botulinum toxin completely free from animal‐derived components including human‐serum albumin, comparing its efficacy and safety…
View article: Temporal changes in symptomatic intracranial arterial disease: a longitudinal high-resolution vessel wall imaging study
Temporal changes in symptomatic intracranial arterial disease: a longitudinal high-resolution vessel wall imaging study Open
Introduction The temporal dynamics of the vessel wall in intracranial arterial disease (ICAD) may differ depending on the etiology. We investigated temporal changes in narrowed intracranial arteries after ischemic stroke using serial high-…
View article: Automated Ischemic Stroke Lesion Detection On Non-Contrast Brain CT: A Large-Scale Clinical Feasibility Test
Automated Ischemic Stroke Lesion Detection On Non-Contrast Brain CT: A Large-Scale Clinical Feasibility Test Open
Background Non-contrast CT (NCCT) is widely used imaging modality for acute stroke imaging but often fails to detect subtle early ischemic changes. Such underestimation can lead clinicians to overlook tissue-level information. This study a…
View article: Segmentation of Leukoaraiosis on Noncontrast Head CT Using CT‐MRI Paired Data Without Human Annotation
Segmentation of Leukoaraiosis on Noncontrast Head CT Using CT‐MRI Paired Data Without Human Annotation Open
Objective Evaluating leukoaraiosis (LA) on CT is challenging due to its low contrast and similarity to parenchymal gliosis. We developed and validated a deep learning algorithm for LA segmentation using CT‐MRIFLAIR paired data from a multi…
View article: Switch to Rosuvastatin Plus Ezetimibe From Statin Monotherapy to Achieve Target LDL-Cholesterol Goal: A Multi-Center, Open-Label, Single-Arm Trial
Switch to Rosuvastatin Plus Ezetimibe From Statin Monotherapy to Achieve Target LDL-Cholesterol Goal: A Multi-Center, Open-Label, Single-Arm Trial Open
View article: Clinical Outcomes of Follicular Thyroid Carcinoma Did Not Significantly Differ according to Tumor Size in an Iodine-Excessive Country
Clinical Outcomes of Follicular Thyroid Carcinoma Did Not Significantly Differ according to Tumor Size in an Iodine-Excessive Country Open
Background: Follicular thyroid carcinoma (FTC) measuring TERT) promoter mutations based on tumor size were evaluated.Results: While the rates of DM, R/SP, and CSD and the frequency of TERT promoter mutations did not differ among…
View article: Machine learning-driven strategies for enhanced pediatric wheezing detection
Machine learning-driven strategies for enhanced pediatric wheezing detection Open
Background Auscultation is a critical diagnostic feature of lung diseases, but it is subjective and challenging to measure accurately. To overcome these limitations, artificial intelligence models have been developed. Methods In this prosp…
View article: Personalized Visual Perceptual Learning Digital Therapy for Visual Field Defects Following Stroke
Personalized Visual Perceptual Learning Digital Therapy for Visual Field Defects Following Stroke Open
Importance Effective treatments for restoring visual field defects (VFDs) in patients with stroke necessitate validation through randomized clinical trials. Objective To evaluate the efficacy and safety of a personalized digital therapeuti…
View article: Comparing two deep learning algorithms for acute infarct segmentation on diffusion-weighted imaging in routine clinical practice
Comparing two deep learning algorithms for acute infarct segmentation on diffusion-weighted imaging in routine clinical practice Open
Objectives Infarct volumes on diffusion-weighted imaging (DWI) are critical for predicting stroke outcomes and guiding late-window endovascular thrombectomy. Although 3D U-Net-based deep learning achieves high sensitivity, it often yields …
View article: Sex Differences in the Clinical and Imaging Characteristics of Korean CADASIL Patients: A Korean Nationwide Retrospective Study
Sex Differences in the Clinical and Imaging Characteristics of Korean CADASIL Patients: A Korean Nationwide Retrospective Study Open
Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small vessel disease caused by NOTCH3 mutations. While CADASIL affects both sexes, differences in clinical pres…
View article: Comparison of various prediction equations for glomerular filtration rate in Korean pediatric cancer patients: a retrospective study
Comparison of various prediction equations for glomerular filtration rate in Korean pediatric cancer patients: a retrospective study Open
Purpose: Assessment of kidney function is essential in the management and follow-up of children with cancer. However, the best method to assess the kidney function in children with cancer is unknown.Methods: The study compared glomerular f…
View article: Tenecteplase for Minor Stroke: Does Sex Matter?
Tenecteplase for Minor Stroke: Does Sex Matter? Open
View article: Deep learning-based automatic segmentation of cerebral infarcts on diffusion MRI
Deep learning-based automatic segmentation of cerebral infarcts on diffusion MRI Open
We explored effects of (1) training with various sample sizes of multi-site vs. single-site training data, (2) cross-site domain adaptation, and (3) data sources and features on the performance of algorithms segmenting cerebral infarcts on…