Jooyeon Oh
YOU?
Author Swipe
View article: Adult K18-hACE2 mice are suitable for studying intranasal SARS-CoV-2 infection but not direct-contact transmission
Adult K18-hACE2 mice are suitable for studying intranasal SARS-CoV-2 infection but not direct-contact transmission Open
The rapid global spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) since 2019 emphasizes the need to understand its transmission routes, which mainly comprise airborne and contact transmission. Contact transmission, wh…
View article: Discovery of a new long COVID mouse model via systemic histopathological comparison of SARS-CoV-2 intranasal and inhalation infection
Discovery of a new long COVID mouse model via systemic histopathological comparison of SARS-CoV-2 intranasal and inhalation infection Open
Intranasal infection is commonly used to establish a SARS-CoV-2 mouse model due to its non-invasive procedures and a minimal effect from the operation itself. However, mice intranasally infected with SARS-CoV-2 have a high mortality rate, …
View article: Immune Cells Are Differentially Affected by SARS-CoV-2 Viral Loads in K18-hACE2 Mice
Immune Cells Are Differentially Affected by SARS-CoV-2 Viral Loads in K18-hACE2 Mice Open
Viral load and the duration of viral shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are important determinants of the transmission of coronavirus disease 2019. In this study, we examined the effects of viral doses…
View article: How Deep Learning in Antiviral Molecular Profiling Identified Anti-SARS-CoV-2 Inhibitors
How Deep Learning in Antiviral Molecular Profiling Identified Anti-SARS-CoV-2 Inhibitors Open
The integration of artificial intelligence (AI) into drug discovery has markedly advanced the search for effective therapeutics. In our study, we employed a comprehensive computational–experimental approach to identify potential anti-SARS-…
View article: SARS-CoV-2 Infection Induces HMGB1 Secretion Through Post-Translational Modification and PANoptosis
SARS-CoV-2 Infection Induces HMGB1 Secretion Through Post-Translational Modification and PANoptosis Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces excessive pro-inflammatory cytokine release and cell death, leading to organ damage and mortality. High-mobility group box 1 (HMGB1) is one of the damage-associ…
View article: Corrigendum: Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits
Corrigendum: Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits Open
[This corrects the article DOI: 10.3389/fimmu.2022.1055811.].
View article: Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits
Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) has been a global health concern since 2019. The viral spike protein infects the host by binding to angiotensin-converting enzyme 2 (A…
View article: Temporal Transcriptome Analysis of SARS-CoV-2-Infected Lung and Spleen in Human ACE2-Transgenic Mice
Temporal Transcriptome Analysis of SARS-CoV-2-Infected Lung and Spleen in Human ACE2-Transgenic Mice Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and potentially fatal virus. So far, most comprehensive analyses encompassing clinical and transcriptional manifestation have concentrated on the lungs.…
View article: Comparison of the pathogenesis of SARS-CoV-2 infection in K18-hACE2 mouse and Syrian golden hamster models
Comparison of the pathogenesis of SARS-CoV-2 infection in K18-hACE2 mouse and Syrian golden hamster models Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, causes life-threatening disease. This novel coronavirus enters host cells via the respiratory tract, promoting the formation of severe pulmona…
View article: <i>In vitro</i> validation of neoantigen prediction algorithm for developing personalized cancer vaccine therapy
<i>In vitro</i> validation of neoantigen prediction algorithm for developing personalized cancer vaccine therapy Open
Background The development of personalized neoantigen-based therapeutic cancer vaccines relies on computational algorithm-based pipelines. One of the critical issues in the pipeline is obtaining higher positive predictive value (PPV) perfo…
View article: In vitro validation of the immunogenicity of the predicted neoepitopes from high-risk estrogen receptor-positive breast cancer
In vitro validation of the immunogenicity of the predicted neoepitopes from high-risk estrogen receptor-positive breast cancer Open
Whether estrogen receptor-positive (ER+) breast cancer (BC) can be a target for therapeutic neoepitope vaccination is not clear due to its low mutation burden. We tested the immunogenicity of predicted neoepitopes from exome and RNA-seq da…