Jopeth Ramis
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View article: A Unified Map of Airway Interactions: Secretome and Mechanotransduction Loops from Development to Disease
A Unified Map of Airway Interactions: Secretome and Mechanotransduction Loops from Development to Disease Open
Human airways maintain homeostasis through intricate cellular interactomes combining secretome-mediated signalling and mechanotransduction feedback loops. This review presents the first unified map of bidirectional mechanobiology–secretome…
View article: Bioprinting of Alginate-Norbornene bioinks to create a versatile platform for kidney in vitro modeling
Bioprinting of Alginate-Norbornene bioinks to create a versatile platform for kidney in vitro modeling Open
Chronic kidney diseases affect a significant portion of the global population and their prevalence is expected to increase in the coming years. Advanced in vitro models are crucial for understanding disease onset and for improving drug tes…
View article: Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release
Mixed polymer and bioconjugate core/shell electrospun fibres for biphasic protein release Open
We report the fabrication of a coaxial electrospun scaffold with a bioactive molecule in the core and a protein conjugated at the surface. To construct the scaffold, we chose polyethylene oxide for the core material and a polycaprolactone/…
View article: LOXL2 Mediates Airway Smooth Muscle Cell Matrix Stiffness and Drives Asthmatic Airway Remodelling
LOXL2 Mediates Airway Smooth Muscle Cell Matrix Stiffness and Drives Asthmatic Airway Remodelling Open
Airway smooth muscle cells (ASM) are fundamental to asthma pathogenesis, influencing bronchoconstriction, airway hyper-responsiveness, and airway remodelling. Extracellular matrix (ECM) can influence tissue remodelling pathways, however, t…
View article: Surface and Morphological Investigation of Synthesized Nanostructured Ridges from Electrospun Polyvinyl Alcohol-Albumin Blend—A Taguchi Design of Experiment Approach
Surface and Morphological Investigation of Synthesized Nanostructured Ridges from Electrospun Polyvinyl Alcohol-Albumin Blend—A Taguchi Design of Experiment Approach Open
We report the synthesis of presumably a “nanoridge” from the electrospinning of a hydrophilic polymer–protein blend. The material exhibits vertical elevation from the substrate, distinct from the morphologies seen in electrospinning. It is…
View article: Growth‐Factor Free Multicomponent Nanocomposite Hydrogels That Stimulate Bone Formation
Growth‐Factor Free Multicomponent Nanocomposite Hydrogels That Stimulate Bone Formation Open
Synthetic osteo‐promoting materials that are able to stimulate and accelerate bone formation without the addition of exogenous cells or growth factors represent a major opportunity for an aging world population. A co‐assembling system that…