Jordan D. Carelli
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View article: An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes
An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes Open
View article: Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes
Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes Open
Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity-determining reaction is facilitated by the GTPase elongation factor-…
View article: Author response: Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes
Author response: Didemnin B and ternatin-4 differentially inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Rapid and accurate mRN…
View article: Didemnin B and ternatin-4 inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes
Didemnin B and ternatin-4 inhibit conformational changes in eEF1A required for aminoacyl-tRNA accommodation into mammalian ribosomes Open
Rapid and accurate mRNA translation requires efficient codon-dependent delivery of the correct aminoacyl-tRNA (aa-tRNA) to the ribosomal A site. In mammals, this fidelity-determining reaction is facilitated by the GTPase elongation factor-…
View article: Reversible lysine-targeted probes reveal residence time-based kinase selectivity
Reversible lysine-targeted probes reveal residence time-based kinase selectivity Open
View article: CCDC 2099722: Experimental Crystal Structure Determination
CCDC 2099722: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer
Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer Open
Control of the cell cycle through selective pharmacological inhibition of CDK4/6 has proven beneficial in the treatment of breast cancer. Extending this level of control to additional cell cycle CDK isoforms represents an opportunity to ex…
View article: Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex
Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex Open
Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic varian…
View article: Author response: Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex
Author response: Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex Open
Full text Figures and data Side by side Abstract eLife digest Introduction Results and discussion Materials and methods Chemical synthesis References Decision letter Author response Article and author information Metrics Abstract Cyclic pe…