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View article: Non-invasive diagnosis of invasive fungal disease with cell-free DNA PCR
Non-invasive diagnosis of invasive fungal disease with cell-free DNA PCR Open
Invasive fungal disease (IFD) is a major cause of morbidity and mortality in the immunocompromised population. Early diagnosis is challenging due to the low sensitivity and non-specificity of non-invasive fungal biomarkers, the need for in…
View article: Cloning and expression of recombinant outer membrane protein A of Orientia tsutsugamushi using Escherichia coli expression systems
Cloning and expression of recombinant outer membrane protein A of Orientia tsutsugamushi using Escherichia coli expression systems Open
OmpA of Orientia tsutsugamushi (OtOmpA) plays an important role during multiple stages of scrub typhus pathogenesis. The bacterial expression system which involves cloning, is commonly used for the production of recombinant proteins. The c…
View article: Accuracy of plasma cell-free DNA PCR for non-invasive diagnosis of mucormycosis
Accuracy of plasma cell-free DNA PCR for non-invasive diagnosis of mucormycosis Open
Diagnosis of mucormycosis poses a substantial challenge due to the lack of a non-invasive biomarker and limitations of conventional diagnostics using invasive specimens. The aim of this study was to characterize the performance of Mucorale…
View article: Plasma Microbial Cell-free DNA Metagenomic Sequencing for Diagnosis of Invasive Fungal Diseases Among High-risk Outpatient and Inpatient Immunocompromised Hosts
Plasma Microbial Cell-free DNA Metagenomic Sequencing for Diagnosis of Invasive Fungal Diseases Among High-risk Outpatient and Inpatient Immunocompromised Hosts Open
Background New and minimally invasive tools to aid the diagnosis of invasive fungal diseases (IFD) are urgently needed as the immunocompromised population at highest risk increases. Advancements in molecular technology have rendered new di…
View article: Dynamics and prognostic value of plasma cell-free DNA PCR in patients with invasive aspergillosis and mucormycosis
Dynamics and prognostic value of plasma cell-free DNA PCR in patients with invasive aspergillosis and mucormycosis Open
Aspergillus species and Mucorales agents are the primary etiologies of invasive fungal disease (IFD). Biomarkers that predict outcomes are needed to improve care. Patients diagnosed with invasive aspergillosis and mucormycosis using plasma…
View article: Spectrum of bacterial pathogens in inflammatory and noninflammatory cutaneous ulcers of American tegumentary leishmaniasis
Spectrum of bacterial pathogens in inflammatory and noninflammatory cutaneous ulcers of American tegumentary leishmaniasis Open
Background: Cutaneous leishmaniasis (CL) ulcers exhibiting an inflammatory phenotype, characterized by purulent exudate, erythema, pain, and/or lymphatic involvement, are empirically treated with antibiotics. Objective: The spectrum of bac…
View article: Superior Accuracy of <i>Aspergillus</i> Plasma Cell-Free DNA Polymerase Chain Reaction Over Serum Galactomannan for the Diagnosis of Invasive Aspergillosis
Superior Accuracy of <i>Aspergillus</i> Plasma Cell-Free DNA Polymerase Chain Reaction Over Serum Galactomannan for the Diagnosis of Invasive Aspergillosis Open
Background Invasive aspergillosis (IA) in immunocompromised hosts carries high morbidity and mortality. Diagnosis is often delayed because definitive diagnosis requires invasive specimen collection, while noninvasive testing with galactoma…
View article: Hepatitis E virus seropositivity in an ethnically diverse community blood donor population
Hepatitis E virus seropositivity in an ethnically diverse community blood donor population Open
Background and Objectives Hepatitis E virus (HEV) is an underrecognized and emerging infectious disease that may threaten the safety of donor blood supply in many parts of the world. We sought to elucidate whether our local community blood…
View article: Answer to June 2023 Photo Quiz
Answer to June 2023 Photo Quiz Open
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View article: <i>Mycobacterium marinum</i> Infection after Iguana Bite in Costa Rica
<i>Mycobacterium marinum</i> Infection after Iguana Bite in Costa Rica Open
Infections after reptile bites are uncommon, and microbial etiologies are not well defined. We describe a case of Mycobacterium marinum soft-tissue infection after an iguana bite in Costa Rica that was diagnosed through 16S rRNA sequencing…
View article: Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection
Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection Open
Tissue-resident immunity underlies essential host defenses against pathogens, but analysis in humans has lacked in vitro model systems where epithelial infection and accompanying resident immune cell responses can be observed en bloc. Inde…
View article: Evaluation of a Semiautomated System for the Quantitation of Human Adenovirus DNA from Clinical Samples
Evaluation of a Semiautomated System for the Quantitation of Human Adenovirus DNA from Clinical Samples Open
Accurate quantification of human adenovirus DNA in the peripheral blood plays a critical role in the management of adenovirus infections in transplant recipients. Many laboratories utilize in-house laboratory-based PCR assays for the quant…
View article: Primary varicella in 2 adult immigrants to Canada
Primary varicella in 2 adult immigrants to Canada Open
KEY POINTSA 50-year-old man presented to the emergency department with 3 days of acute severe chest pain that radiated to his back, subjective fever and decreased oral intake. He had a history of diabetes, hypertension and dyslipidemia, fo…
View article: Case report: Immune profiling links neutrophil and plasmablast dysregulation to microvascular damage in post-COVID-19 Multisystem Inflammatory Syndrome in Adults (MIS-A)
Case report: Immune profiling links neutrophil and plasmablast dysregulation to microvascular damage in post-COVID-19 Multisystem Inflammatory Syndrome in Adults (MIS-A) Open
Despite surviving a SARS-CoV-2 infection, some individuals experience an intense post-infectious Multisystem Inflammatory Syndrome (MIS) of uncertain etiology. Children with this syndrome (MIS-C) can experience a Kawasaki-like disease, but…
View article: Microbiological Characterization of Actinotignum schaalii Strains Causing Invasive Infections during a Multiyear Period in a Large Canadian Health Care Region
Microbiological Characterization of Actinotignum schaalii Strains Causing Invasive Infections during a Multiyear Period in a Large Canadian Health Care Region Open
Actinotignum schaalii is an underrecognized Gram-positive bacillus due to its special growth requirements and prior phenotypic identification methods, and it is often mistaken as a contaminant. It has been associated with various clinical …
View article: The impact of the COVID-19 pandemic on malaria in returning travellers in Canada: a retrospective population-based cohort study
The impact of the COVID-19 pandemic on malaria in returning travellers in Canada: a retrospective population-based cohort study Open
In high-income, low-prevalence settings, travel patterns largely govern malaria transmission; the COVID-19 pandemic has led to travel restrictions resulting in a decrease in malaria case incidence. The proportion of travellers seeking pre-…
View article: Isolated Pulmonary Emergomycosis in an Immunocompetent Patient in Alberta, Canada
Isolated Pulmonary Emergomycosis in an Immunocompetent Patient in Alberta, Canada Open
Emergomyces canadensis pulmonary infection was incidentally diagnosed in an asymptomatic patient suspected to have metastatic osteosarcoma. Molecular diagnosis was imperative to fungal identification given overlapping histopathological fea…
View article: A case of disseminated strongyloidiasis after multiple courses of immunosuppression
A case of disseminated strongyloidiasis after multiple courses of immunosuppression Open
KEY POINTS A 71-year-old man presented to the emergency department with a 4-month history of weight loss, anorexia and constipation, and a 2-week history of abdominal pain. He had biopsy-proven immunoglobulin G4 (IgG4)-related disease invo…
View article: A case of multisystem inflammatory syndrome in adults following natural infection and subsequent immunization
A case of multisystem inflammatory syndrome in adults following natural infection and subsequent immunization Open
Multisystem inflammatory syndrome in adults is a rare and life-threatening complication that follows natural COVID-19 infection and primarily affects young unvaccinated adults. This complication is seldom described following vaccination, w…
View article: 1361. <i>Actinotignum schaalii</i> an Under-recognized Cause of Infections: A Case Series in Calgary from 2012 - 2020
1361. <i>Actinotignum schaalii</i> an Under-recognized Cause of Infections: A Case Series in Calgary from 2012 - 2020 Open
Background Actinotignum schaalii is a gram-positive rod that is a fastidious commensal of the urogenital tract. Infections with A. schaalii are underdiagnosed previously because phenotypic methods fail to identify it. Both MALDI-TOF mass s…
View article: Comparison of hospitalized patients with COVID-19 who did and did not live in residential care facilities in Montréal: a retrospective case series
Comparison of hospitalized patients with COVID-19 who did and did not live in residential care facilities in Montréal: a retrospective case series Open
During the first wave of the COVID-19 epidemic in Montréal, more than one-third of RCF residents hospitalized with SARS-CoV-2 infection died during hospitalization. Policies and practices that prevent future outbreaks of SARS-CoV-2 infecti…