Jordan Ray
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View article: Truncating Titin and Lamin A/C Variants in Anthracycline-Induced Cardiomyopathy
Truncating Titin and Lamin A/C Variants in Anthracycline-Induced Cardiomyopathy Open
Three of 18 anthracycline CCM patients carried likely pathogenic variants in the most common causative genes for idiopathic dilated cardiomyopathy, TTN, and lamin A/C. Rare nonsynonymous variants in ryanodine receptor 2 and other idiopathi…
View article: Concomitant Transthyretin Amyloid Cardiomyopathy in Patients With Multiple Myeloma
Concomitant Transthyretin Amyloid Cardiomyopathy in Patients With Multiple Myeloma Open
ATTR-CM can occur in patients with multiple myeloma. Endomyocardial biopsy is essential to accurately distinguish ATTR-CM from AL-CM in the presence of plasma cell dyscrasia and to ensure appropriate and timely treatment.
View article: Outcomes in Asymptomatic Patients Undergoing Coronary Revascularization Before Liver Transplantation
Outcomes in Asymptomatic Patients Undergoing Coronary Revascularization Before Liver Transplantation Open
Background: Coronary artery disease (CAD) is common among liver transplantation (LT) candidates, yet whether pre-transplant percutaneous coronary intervention (PCI) improves post-LT outcomes remains uncertain. Methods: We conducted a singl…
View article: Percutaneous Removal of Cardiac Papillary Fibroelastomas
Percutaneous Removal of Cardiac Papillary Fibroelastomas Open
Papillary fibroelastomas (PFEs) are primary cardiac tumors associated with significant embolic risk. Surgical excision or medical therapy with antiplatelets and/or anticoagulants have been the treatment options for symptomatic patients. Th…
View article: Mitral Annulus Calcium Score in Patients With Calcific Mitral Stenosis Undergoing Invasive Hemodynamic Assessment
Mitral Annulus Calcium Score in Patients With Calcific Mitral Stenosis Undergoing Invasive Hemodynamic Assessment Open
Background Aortic valve calcium score is associated with hemodynamic severity of aortic stenosis. Whether this association is present in calcific mitral stenosis remains unknown. Methods and Results This study was a retrospective analysis …
View article: Cardio-Oncology for the Primary Care Provider
Cardio-Oncology for the Primary Care Provider Open
Cardiovascular disease is a major cause of mortality among oncologic patients. As cancer therapies continue to evolve and advance, cancer survival rates have been increasing and so has the burden of cardiovascular disease within this popul…
View article: Replication of genetic associations of chemotherapy-related cardiotoxicity in the adjuvant NSABP B-31 clinical trial
Replication of genetic associations of chemotherapy-related cardiotoxicity in the adjuvant NSABP B-31 clinical trial Open
Background The cardiotoxic effects of doxorubicin, trastuzumab, and other anticancer agents are well known, but molecular genetic testing is lacking for the early identification of patients at risk for therapy-related cardiac toxicity. Met…
View article: Prediction of Atrial Arrhythmia after Allogenic Transplantation Using Artificial Intelligence-Enabled ECG
Prediction of Atrial Arrhythmia after Allogenic Transplantation Using Artificial Intelligence-Enabled ECG Open
NKG2D is a major activation receptor on natural killer (NK) cells and a unique receptor on Cd8 T cells and subsets of NKT and γδ T cells. NKG2D is generally absent on CD4 T cells. The ligand of NKG2D (NKG2D-L) is generally absent on normal…
View article: Upregulation of Endothelin-1 May Predict Chemotherapy-Induced Cardiotoxicity in Women with Breast Cancer
Upregulation of Endothelin-1 May Predict Chemotherapy-Induced Cardiotoxicity in Women with Breast Cancer Open
As survival in breast cancer patients from newer therapies increases, concerns for chemotherapy-induced cardiotoxicity (CIC) have offset some of these benefits, manifesting as a decline in left ventricular ejection fraction (LVEF). Patient…
View article: Macrophage Activation Led Acute Heart Failure Managed Successfully with Immunosuppression
Macrophage Activation Led Acute Heart Failure Managed Successfully with Immunosuppression Open
Macrophage activation leading to multi-organ dysfunction/failure has been described in various hematologic disorders like hemophagocytic lympho-histiocytosis (HLH), also known as macrophage activation syndrome (MAS) and macrophage activati…
View article: Association of Genetic Variants at TRPC6 With Chemotherapy-Related Heart Failure
Association of Genetic Variants at TRPC6 With Chemotherapy-Related Heart Failure Open
Background: Our previous GWAS identified genetic variants at six novel loci that were associated with a decline in left ventricular ejection fraction (LVEF), p < 1 × 10-5 in 1,191 early breast cancer patients from the N9831 clinical trial …
View article: Subaortic Membrane Papillary Fibroelastoma
Subaortic Membrane Papillary Fibroelastoma Open
A 61-year-old male presented for an annual exam and received a transthoracic echocardiogram (TTE) which revealed a mobile mass arising from a subaortic membrane. Further investigations with a transesophageal echocardiogram (TEE) and cardia…
View article: Eosinophillic Myocarditis Secondary to Metastatic Melanoma
Eosinophillic Myocarditis Secondary to Metastatic Melanoma Open
Eosinophilic myocarditis is a rare form of myocarditis that may manifest from cancer-mediated inflammation. A case of eosinophilic myocarditis secondary to metastatic melanoma is described; metastatic melanoma can cause a T helper type 2 l…
View article: Eosinophillic Myocarditis Secondary to Metastatic Melanoma
Eosinophillic Myocarditis Secondary to Metastatic Melanoma Open
Eosinophilic myocarditis is a rare form of myocarditis that may manifest from cancer-mediated inflammation. A case of eosinophilic myocarditis secondary to metastatic melanoma is described; metastatic melanoma can cause a T helper type 2 l…