Jordana C. Bloom
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View article: Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection
Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection Open
Malignant testicular germ cells tumors (TGCTs) are the most common solid cancers in young men. Current TGCT diagnostics include conventional serum protein markers, but these lack the sensitivity and specificity to serve as accurate markers…
View article: Moving Beyond the Device: Key Lessons in Creating a Positive Patient Experience for a Remote Foot Health Program
Moving Beyond the Device: Key Lessons in Creating a Positive Patient Experience for a Remote Foot Health Program Open
The burden of diabetic foot ulcers is largely underappreciated, even by the healthcare community. Living with advanced, complex chronic diseases can be challenging for the patient and often requires additional time and resource utilization…
View article: Transcriptomic Insights into Hypothalamic Aging During Menopause: A Comparative Analysis of Human and Mouse Models
Transcriptomic Insights into Hypothalamic Aging During Menopause: A Comparative Analysis of Human and Mouse Models Open
Menopause significantly impacts women’s health, yet hypothalamic changes during this transition remain poorly understood. We analyzed gene expression in human hypothalamic samples across menopausal stages, revealing significant changes in …
View article: OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity
OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity Open
Three sisters, born from consanguineous parents, manifested a unique Müllerian anomaly characterized by uterine hypoplasia with thin estrogen-unresponsive endometrium and primary amenorrhea, but with spontaneous tubal pregnancies. Through …
View article: Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection
Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection Open
Malignant testicular germ cells tumors (TGCTs) are the most common solid cancers in young men. Current TGCT diagnostics include conventional serum protein markers, but these lack the sensitivity and specificity to serve as accurate markers…
View article: Imaging optically thick tissues simply and reproducibly: a practical guide to Lightsheet Macroscopy
Imaging optically thick tissues simply and reproducibly: a practical guide to Lightsheet Macroscopy Open
Lightsheet microscopy offers an ideal method for imaging of large (mm-cm scale) biological tissues rendered transparent via optical clearing protocols. However the diversity of clearing technologies and tissue types, and how these are adap…
View article: Sexually dimorphic DNA damage responses and mutation avoidance in the mouse germline
Sexually dimorphic DNA damage responses and mutation avoidance in the mouse germline Open
Germ cells specified during fetal development form the foundation of the mammalian germline. These primordial germ cells (PGCs) undergo rapid proliferation, yet the germline is highly refractory to mutation accumulation compared with somat…
View article: Automating Inference of Binary Microlensing Events with Neural Density\n Estimation
Automating Inference of Binary Microlensing Events with Neural Density\n Estimation Open
Automated inference of binary microlensing events with traditional\nsampling-based algorithms such as MCMC has been hampered by the slowness of the\nphysical forward model and the pathological likelihood surface. Current\nanalysis of such …
View article: Single Cell Analysis Reveals Multi-faceted miR-375 Regulation of the Intestinal Crypt
Single Cell Analysis Reveals Multi-faceted miR-375 Regulation of the Intestinal Crypt Open
Summary The role of individual miRNAs in small intestinal (SI) epithelial homeostasis is under-explored. In this study, we discovered that miR-375 is among the most enriched miRNAs in intestinal crypts and stem cells (ISCs), especially fac…
View article: Sexually Dimorphic DNA Damage Responses and Mutation Avoidance in the Mouse Germline
Sexually Dimorphic DNA Damage Responses and Mutation Avoidance in the Mouse Germline Open
Germ cells specified during fetal development form the foundation of the mammalian germline. These primordial germ cells (PGCs) undergo rapid proliferation, yet the germline is highly refractory to mutation accumulation compared to somatic…
View article: A reporter mouse for in vivo detection of <scp>DNA</scp> damage in embryonic germ cells
A reporter mouse for in vivo detection of <span>DNA</span> damage in embryonic germ cells Open
Summary Maintaining genome integrity in the germline is essential for survival and propagation of a species. In both mouse and human, germ cells originate during fetal development and are hypersensitive to both endogenous and exogenous DNA…
View article: Oocyte Elimination Through DNA Damage Signaling from CHK1/CHK2 to p53 and p63
Oocyte Elimination Through DNA Damage Signaling from CHK1/CHK2 to p53 and p63 Open
Unrepaired DNA damage in mouse oocytes leads to apoptosis, in part via CHK2 signaling to TRP53 and TRP63. Here, Rinaldi, Bloom, and Schimenti provide evidence that CHK1 can also be involved, especially... Eukaryotic organisms have evolved …
View article: SKP1 drives the prophase I to metaphase I transition during male meiosis
SKP1 drives the prophase I to metaphase I transition during male meiosis Open
SKP1 coordinates chromosome synapsis and meiotic recombination with progression through the first meiotic cell division in mouse.
View article: A Reporter Mouse for<i>In Vivo</i>Detection of DNA Damage in Embryonic Germ Cells
A Reporter Mouse for<i>In Vivo</i>Detection of DNA Damage in Embryonic Germ Cells Open
Maintaining genome integrity in the germline is essential for survival and propagation of a species. In both mouse and human, germ cells originate during fetal development and are hypersensitive to both endogenous and exogenous DNA damagin…
View article: Signaling to TRP53 and TAp63 from CHK1/CHK2 is responsible for elimination of most oocytes defective for either chromosome synapsis or recombination
Signaling to TRP53 and TAp63 from CHK1/CHK2 is responsible for elimination of most oocytes defective for either chromosome synapsis or recombination Open
Eukaryotic organisms have evolved mechanisms to prevent the accumulation of cells bearing genetic aberrations. This is especially crucial for the germline, because fecundity, and fitness of progeny would be adversely affected by an excessi…
View article: Germline genome protection: implications for gamete quality and germ cell tumorigenesis
Germline genome protection: implications for gamete quality and germ cell tumorigenesis Open
Background Germ cells have a unique and critical role as the conduit for hereditary information and therefore employ multiple strategies to protect genomic integrity and avoid mutations. Unlike somatic cells, which often respond to DNA dam…
View article: Female-biased embryonic death from inflammation induced by genomic instability
Female-biased embryonic death from inflammation induced by genomic instability Open
Genomic instability can trigger cellular responses that include checkpoint activation, senescence and inflammation1,2. Although genomic instability has been extensively studied in cell culture and cancer paradigms, little is kno…
View article: Female-biased embryonic death from genomic instability-induced inflammation
Female-biased embryonic death from genomic instability-induced inflammation Open
Genomic instability (GIN) can trigger cellular responses including checkpoint activation, senescence, and inflammation. Though extensively studied in cell culture and cancer paradigms, little is known about the impact of GIN during embryon…
View article: Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3
Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3 Open
View article: Whole Mount Immunofluorescence and Follicle Quantification of Cultured Mouse Ovaries
Whole Mount Immunofluorescence and Follicle Quantification of Cultured Mouse Ovaries Open
Research in the field of mammalian reproductive biology often involves evaluating the overall health of ovaries and testes. Specifically, in females, ovarian fitness is often assessed by visualizing and quantifying follicles and oocytes. B…
View article: Mouse Genetics 2016: meeting report
Mouse Genetics 2016: meeting report Open