Explanipedia

Higher adherence to (poly)phenol-rich diet is associated with lower CVD risk in the TwinsUK cohort Open

Yong Li, Xinyu Yan, Robert K. Pope, Tim D. Spector, Mario Falchi , et al. · 2025

Background Previous studies have reported inverse associations between total (poly)phenol intake or specific subclasses of (poly)phenols, estimated from dietary questionnaires, and cardiovascular disease (CVD) risk. However, no studies hav…

DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation Open

Melissa A. Richard, Tianxiao Huan, Symen Ligthart, Rahul Gondalia, Min A. Jhun , et al. · 2025

DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease Open

Lucy Sinke, Thomas Delerue, Rory Wilson, Xueling Lu, Yujing Xia , et al. · 2025

Aims/hypothesis Despite playing critical roles in the pathophysiology of type 2 diabetes and other metabolic disorders, the molecular mechanisms underlying circulating adipokine levels remain poorly understood. By identifying genomic regio…

A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison Open

Xueyi Shen, Miruna C. Barbu, Doretta Caramaschi, Ryan Arathimos, Darina Czamara , et al. · 2025

Major depression (MD) is a leading cause of global disease burden, and both experimental and population-based studies suggest that differences in DNA methylation may be associated with the condition. However, previous DNA methylation studi…

Erratum to “Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic-Resistant Organisms (FERARO): A feasibility randomised controlled trial” [J Infect 91 (2025) 106504] Open

Blair Merrick, Désirée Prossomariti, Elizabeth Allen, Karen Bisnauthsing, Michael Kertanegara , et al. · 2025

The publisher regrets that an error was made with the upload of the supplementary material. The CONSORT 2010 checklist page numbering is incorrect and relates to a previous typesetting of the article. A revised document correcting the page…

Genetic regulation of fatty acid content in adipose tissue Open

Xiaolang Yan, Amy L. Roberts, Julia S. El-Sayed Moustafa, Sergio Villicaña, Maryam Al‐Hilal , et al. · 2025

Fatty acids are important as structural components, energy sources, and signaling mediators. While studies have extensively explored genetic regulation of fatty acids in serum and other bodily fluids, their regulation within adipose tissue…

Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic-Resistant Organisms (FERARO): A feasibility randomised controlled trial Open

Blair Merrick, Désirée Prossomariti, Elizabeth Allen, Karen Bisnauthsing, Michael Kertanegara , et al. · 2025

Progression to a substantive trial is feasible with modifications to the existing FERARO protocol. FMT was safe, well tolerated, and acceptable to patients colonised with MDRO. Microbiome analysis infers that greater donor-recipient microb…

Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids Open

Min-A Jhun, Michael Mendelson, Rory P. Wilson, Rahul Gondalia, Roby Joehanes , et al. · 2025

Twin pair analysis uncovers links between DNA methylation, mitochondrial DNA quantity and obesity Open

Aino Heikkinen, Vivienne F. C. Esser, Seung Hyuk Lee, Sara Lundgren, Antti Hakkarainen , et al. · 2025

Alterations in mitochondrial metabolism in obesity may indicate disrupted communication between mitochondria and nucleus, and DNA methylation may influence this interplay. Here, we leverage data from the Finnish Twin Cohort study subcohort…

Theobromine is Associated with Slower Epigenetic Ageing Open

Ramy Saad, Ricardo Costeira, Pablo Aurelio Gómez-García, Christian Gieger, Karsten Suhre , et al. · 2025

Theobromine, a commonly consumed dietary alkaloid derived from cocoa, has been linked to extended lifespan in model organisms and to health benefits in humans. We examined associations between circulating theobromine intake, measured using…

ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition—implications for COVID-19 Open

Julia S. El-Sayed Moustafa, Anne Jackson, Sarah M. Brotman, Li Guan, Sergio Villicaña , et al. · 2025

Quantification of heavy metal exposure in a British population cohort links total mercury levels in plasma with skin tissue-specific changes in mitochondrial-related gene expression Open

Marcel Van de Streek, Aminah T. Ali, Julia S. El-Sayed Moustafa, Craig A. Glastonbury, Tim D. Spector , et al. · 2025

Heavy metals in our direct environment have profound effects on human health and while some are essential for life, others can be toxic. In vivo studies often focus on clinical features caused by overexposure to, or by deprivation of a hea…

DNA methylation and gene expression trajectories of human postprandial metabolism Open

Ricardo Costeira, Lidia Daimiel, Thies Gehrmann, Fatih A. Bogaards, Sergio Villicaña , et al. · 2024

Human postprandial metabolism is characterised by a highly individualised response to food that is predictive of cardiometabolic health and underexplored at the molecular level. We profiled blood DNA methylation (DNAm) and gene expression …

Epigenetic associations with kidney disease in individuals of African ancestry with APOL1 high-risk genotypes and HIV Open

Rachel Hung, Ricardo Costeira, Junyu Chen, Pascal Schlosser, Franziska Grundner-Culemann , et al. · 2024

Background Apolipoprotein L1 (APOL1) high-risk variants are major determinants of chronic kidney disease (CKD) in people of African ancestry. Previous studies have identified epigenetic changes in relation to kidney function and CKD, but n…

Genetic effects on the skin methylome in healthy older twins Open

Christopher J. Shore, Sergio Villicaña, Julia S. El-Sayed Moustafa, Amy L. Roberts, David A. Gunn , et al. · 2024

Development of a (Poly)phenol Metabolic Signature for Assessing (Poly)phenol-Rich Dietary Patterns Open

Yong Li, Yifan Xu, Mélanie Le Sayec, Xinyu Yan, Tim D. Spector , et al. · 2024

The objective assessment of habitual (poly)phenol-rich diets in nutritional epidemiology studies remains challenging. This study developed and evaluated the metabolic signature of a (poly)phenol-rich dietary score (PPS) using a targeted me…

Blood DNA methylation sites predict death risk in a longitudinal study of 12,300 individuals Open

Elena Colicino, Riccardo E. Marioni, Cavin Ward‐Caviness, Raj Gondalia, Wenqiang Guan , et al. · 2024

DNA methylation has fundamental roles in gene programming and aging that may help predict mortality. However, no large-scale study has investigated whether site-specific DNA methylation predicts all-cause mortality. We used the Illumina-Hu…

Epigenome-wide association study of diet quality in the Women’s Health Initiative and TwinsUK cohort Open

W.L Do, Eric A. Whitsel, Ricardo Costeira, Olatz M. Masachs, Caroline I. Le Roy , et al. · 2024

Background: Diet quality is a risk factor for chronic disease and mortality. Differential DNA methylation across the epigenome has been associated with chronic disease risk. Whether diet quality is associated with differential methylation …

A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids Open

Min-A Jhun, Michael Mendelson, Rory Wilson, Raj Gondalia, Roby Joehanes , et al. · 2024

Here we examine the association between DNA methylation in circulating leukocytes and blood lipids in a multi-ethnic sample of 16,265 subjects. We identify 148, 35, and 4 novel associations among Europeans, African Americans, and Hispanics…

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis Open

Jun Liu, Elena Carnero‐Montoro, Jenny van Dongen, Samantha Lent, Ivana Nedeljković , et al. · 2024

Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pa…

Enhanced resolution profiling in twins reveals differential methylation signatures of type 2 diabetes with links to its complications Open

Colette Christiansen, Louis Potier, Tiphaine Martin, Sergio Villicaña, Juan Castillo‐Fernandez , et al. · 2024

Funding acknowledgements for each cohort can be found in the Supplementary Note.

Serum metabolites reflecting gut microbiome alpha diversity predict type 2 diabetes Open

Cristina Menni, J. Zhu, Caroline Le Roy, Olatz Mompeó, Katherine Young , et al. · 2024

Type 2 diabetes (T2D) is associated with reduced gut microbiome diversity, although the cause is unclear. Metabolites generated by gut microbes also appear to be causative factors in T2D. We therefore searched for serum metabolites predict…

Pulmonary Function and Blood DNA Methylation A Multiancestry Epigenome-Wide Association Meta-analysis Open

M. Lee, Tianxiao Huan, Daniel L. McCartney, Geetha Chittoor, Margreet R. de Vries , et al. · 2024

Rationale: Methylation integrates factors present at birth and modifiable across the lifespan that can influence pulmonary function. Studies are limited in scope and replication. Objectives: To conduct large-scale epigenome-wide meta-analy…

Association of dietary folate and Vitamin B-12 intake with genome-wide DNA methylation in blood: A large-scale epigenome-wide association analysis in 5841 individuals Open

Pooja R. Mandaviya, Roby Joehanes, Jennifer A. Brody, Juan Castillo‐Fernandez, Koen F. Dekkers , et al. · 2024

Background: Folate and vitamin B-12 are essential micronutrients involved in the donation of methyl groups in cellular metabolism. However, associations between intake of these nutrients and genome-wide DNA methylation levels have not been…

Cross-sectional analyses of metabolites across biological samples mediating dietary acid load and chronic kidney disease Open

Ilias Attaye, Beverley Beynon-Cobb, Panayiotis Louca, Ana Nogal, Alessia Visconti , et al. · 2024

Detecting genetic effects on phenotype variability to capture gene-by-environment interactions: a systematic method comparison Open

Xiaopu Zhang, Jordana T. Bell · 2024

Genetically associated phenotypic variability has been widely observed across organisms and traits, including in humans. Both gene-gene and gene-environment interactions can lead to an increase in genetically associated phenotypic variabil…

Usual dietary intake and change in DNA methylation over years: EWAS in KORA FF4 and KORA fit Open

Fabian Hellbach, Dennis Freuer, Christa Meisinger, Annette Peters, Juliane Winkelmann , et al. · 2024

Introduction Changes in DNA methylation can increase or suppress the expression of health-relevant genes. We investigated for the first time the relationship between habitual food consumption and changes in DNA methylation. Methods The Ger…

Quantification of Heavy Metal Exposure in a British Population Cohort Links Blood Levels of Mercury with Skin Tissue-Specific Changes in Mitochondrial-Related Gene Expression Open

Marcel Van de Streek, Aminah T. Ali, Julia S. El-Sayed Moustafa, Craig A. Glastonbury, Tim D. Spector , et al. · 2024

Epigenome-wide Association Study Shows Differential DNA Methylation of MDC1, KLF9, and CUTA in Autoimmune Thyroid Disease Open

Nicole Lafontaine, Christopher J. Shore, Purdey J. Campbell, Benjamin H. Mullin, Suzanne J. Brown , et al. · 2023

Context Autoimmune thyroid disease (AITD) includes Graves disease (GD) and Hashimoto disease (HD), which often run in the same family. AITD etiology is incompletely understood: Genetic factors may account for up to 75% of phenotypic varian…

Trans-ancestry epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use Open

Fang Fang, Bryan C. Quach, Kaitlyn G. Lawrence, Jenny van Dongen, Jesse A. Marks , et al. · 2023

Jordana T. Bell YOU? Author Swipe