Jordi García
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View article: New UB006 Derivatives With Higher Solubility and Cytotoxic Activity in Ovarian Cancer Cells
New UB006 Derivatives With Higher Solubility and Cytotoxic Activity in Ovarian Cancer Cells Open
Background/Objectives: The compound (±)-UB006 ((4SR,5SR)-4-(hydroxymethyl)-3-methylene-5-octyldihydrofuran-2(3H)-one) is a promising anti-cancer molecule. The enantiomer (–)-UB006 displays a potent cytotoxic effect in several tumor cell li…
View article: 20403. NIVELES SÉRICOS DE NEUROFILAMENTOS DE CADENA LIGERA COMO FACTOR PREDICTOR DE RESPUESTA EN UNA COHORTE MULTICÉNTRICA DE PACIENTES CON ESCLEROSIS MÚLTIPLE TRATADOS CON OCRELIZUMAB
20403. NIVELES SÉRICOS DE NEUROFILAMENTOS DE CADENA LIGERA COMO FACTOR PREDICTOR DE RESPUESTA EN UNA COHORTE MULTICÉNTRICA DE PACIENTES CON ESCLEROSIS MÚLTIPLE TRATADOS CON OCRELIZUMAB Open
View article: 20930. EL FENÓMENO DE DISFOTOPSIA, SECUELAS VISUALES ASOCIADAS A CIRUGÍA REFRACTIVA
20930. EL FENÓMENO DE DISFOTOPSIA, SECUELAS VISUALES ASOCIADAS A CIRUGÍA REFRACTIVA Open
View article: CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst Open
View article: Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance
Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling the energy balance Open
Targeting brain lipid metabolism using polymeric-based nanomedicine is a promising strategy to regulate the energy balance and fight metabolic diseases such as obesity.
View article: A next generation therapy to treat obesity throughthe brain
A next generation therapy to treat obesity throughthe brain Open
Obesity has become an important health problem and its prevalence is highlyincreasing. Pharmacotherapy alone or in combination with either lifestylemodification or surgery, is consistent in maintaining a healthy body weight, andpreventing …
View article: Degradation of Fatty Acid Phase-Change Materials (PCM): New Approach for Its Characterization
Degradation of Fatty Acid Phase-Change Materials (PCM): New Approach for Its Characterization Open
The use of adequate thermal energy storage (TES) systems is an efficient way to achieve thermal comfort in buildings reducing the cooling and heating demand. Besides, deploy phase change materials (PCM) to meet and enhance the TES needs is…
View article: CCDC 2038593: Experimental Crystal Structure Determination
CCDC 2038593: Experimental Crystal Structure Determination Open
View article: Pyridine- and Quinoline-Derived Imines as <i>N</i>,<i>N</i>-Bidentate Directing Groups in Palladium versus Platinum C–H Bond Activation Reactions
Pyridine- and Quinoline-Derived Imines as <i>N</i>,<i>N</i>-Bidentate Directing Groups in Palladium versus Platinum C–H Bond Activation Reactions Open
The C-H activation by Pd(II) and Pt(II) compounds of a wide range of imines related to 2-pyridinecarboxaldehyde, ArCH═NCH2(CH2)nPh (Ar = 2-pyridinyl, 2-picolinyl, 2-quinolinyl, n = 0, 1), which can be useful for bond functionalization assi…
View article: CCDC 2038592: Experimental Crystal Structure Determination
CCDC 2038592: Experimental Crystal Structure Determination Open
View article: A New Meaning of the Expression s.t-wr.t.: Place where the King is Crowned and Receives the Signs of the Sed-Festival
A New Meaning of the Expression s.t-wr.t.: Place where the King is Crowned and Receives the Signs of the Sed-Festival Open
The present article proposes a new connotation to the expression s.t-wr.t, “Great Place”, that could be added to the several meanings that Egyptology has already bestowed on this term. It will be shown that the s.t-wr.t could also refer to…
View article: An Enantioselective Approach to 4-Substituted Proline Scaffolds: Synthesis of (S)-5-(tert-Butoxy carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic Acid
An Enantioselective Approach to 4-Substituted Proline Scaffolds: Synthesis of (S)-5-(tert-Butoxy carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic Acid Open
A catalytic and enantioselective preparation of the (S)-4-methyleneproline scaffold is described. The key reaction is a one-pot double allylic alkylation of an imine analogue of glycine in the presence of a chinchonidine-derived catalyst u…
View article: A New Nanomedicine Platform to Deliver a Carnitine Palmitoyl-Transferase 1 (CPT1) Inhibitor into Glioma Cells and Neurons
A New Nanomedicine Platform to Deliver a Carnitine Palmitoyl-Transferase 1 (CPT1) Inhibitor into Glioma Cells and Neurons Open
Obesity and glioblastoma multiforme (GB) are two unmet medical needs where effective therapies are lacking. Carnitine palmitoyl transferase 1 (CPT1), an enzyme catalyzing the rate-limiting step in fatty acid oxidation (FAO), is a viable ta…
View article: Essentiality of Managing the Resource Information in the Coordinated Fog-to-Cloud Paradigm
Essentiality of Managing the Resource Information in the Coordinated Fog-to-Cloud Paradigm Open
Fog-to-Cloud (F2C) computing is an emerging computational platform. By combing the cloud, fog, and IoT, it provides an excellent framework for managing and coordinating the resources in any smart computing domain. Efficient management of t…
View article: CCDC 1918188: Experimental Crystal Structure Determination
CCDC 1918188: Experimental Crystal Structure Determination Open
View article: CCDC 1918190: Experimental Crystal Structure Determination
CCDC 1918190: Experimental Crystal Structure Determination Open
View article: CCDC 1918187: Experimental Crystal Structure Determination
CCDC 1918187: Experimental Crystal Structure Determination Open
View article: CCDC 1918189: Experimental Crystal Structure Determination
CCDC 1918189: Experimental Crystal Structure Determination Open
View article: An Architectural Schema for Performance Prediction using Machine Learning in the Fog-to-Cloud Paradigm
An Architectural Schema for Performance Prediction using Machine Learning in the Fog-to-Cloud Paradigm Open
The Fog-to-Cloud (F2C) paradigm is emerging to both provide higher functional efficiency for latency-sensitive services and also help modern computing systems to be more intelligent. As it is still in its infancy, the biggest challenge for…
View article: CCDC 1883868: Experimental Crystal Structure Determination
CCDC 1883868: Experimental Crystal Structure Determination Open
View article: Synthesis of new Carnitine Palmitoyltransferase I inhibitors derivatives of C75
Synthesis of new Carnitine Palmitoyltransferase I inhibitors derivatives of C75 Open
Carnitine Palmitoyltransferase (CPT1) is an enzyme that catalyzes the transport of fatty acids from the cytosol into the mitochondria. CPT1 inhibition in the hypothalamus increases fatty acid levels, which produces an increased expression …
View article: Synthesis of new C75 derivatives, Fatty Acid Synthase inhibitors with cytotoxic properties
Synthesis of new C75 derivatives, Fatty Acid Synthase inhibitors with cytotoxic properties Open
The fatty-acid synthase (FAS) is the key enzyme that executes de novo fatty acid synthesis and is overexpressed in some human cancer tissues. C75 is a synthetic FAS inhibitor, which produces the death of cancer cells. In this work, we synt…
View article: Access to indolines from primary phenylethylamines by an unexpected palladium-catalyzed C–H functionalization process
Access to indolines from primary phenylethylamines by an unexpected palladium-catalyzed C–H functionalization process Open
A new method for the preparation of 2,2-disubstituted indolines from 2-phenylethylamines was developed under Pd catalysis and PhI(OAc)2 as oxidant.
View article: Designed asymmetric coordination helicates with bis-β-diketonate ligands
Designed asymmetric coordination helicates with bis-β-diketonate ligands Open
Through chemical design, an asymmetric bis-β-diketonate ligand has been prepared and engineered to form triple-stranded dinuclear supramolecular helicates, exhibiting structural asymmetry.
View article: Do we really need cloud? Estimating the fog computing capacities in the city of Barcelona
Do we really need cloud? Estimating the fog computing capacities in the city of Barcelona Open
Fog computing has emerged as a novel and challenging technology intended to complement the features of the cloud computing paradigm by exploiting the opportunities of locality. Moving some computation to the edge of the network is especial…
View article: A Literature Survey on Ontology of Different Computing Platforms in\n Smart Environments
A Literature Survey on Ontology of Different Computing Platforms in\n Smart Environments Open
Smart environments integrates various types of technologies, including cloud\ncomputing, fog computing, and the IoT paradigm. In such environments, it is\nessential to organize and manage efficiently the broad and complex set of\nheterogen…
View article: A Magneto‐optical Molecular Device: Interplay of Spin Crossover, Luminescence, Photomagnetism, and Photochromism
A Magneto‐optical Molecular Device: Interplay of Spin Crossover, Luminescence, Photomagnetism, and Photochromism Open
A bis(pyrazolylpyridyl) ligand, L, containing a central photochromic dithienylethene spacer predictably forms a ferrous [Fe 2 L 3 ] 4+ helicate exhibiting spin crossover (SCO). In solution, the compound [Fe 2 L 3 ](ClO 4 ) 4 ( 1 ) preserve…
View article: Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer.
Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer. Open
Fatty acid synthase (FASN) is a key lipogenic enzyme for de novo fatty acid biosynthesis and a druggable metabolic oncoprotein that is activated in most human cancers. We evaluated whether the HER2-driven lipogenic phenotype might represen…
View article: Molecules Designed to Contain Two Weakly Coupled Spins with a Photoswitchable Spacer
Molecules Designed to Contain Two Weakly Coupled Spins with a Photoswitchable Spacer Open
Controlling the charges and spins of molecules lies at the heart of spintronics. A photoswitchable molecule consisting of two independent spins separated by a photoswitchable moiety was designed in the form of new ligand H 4 L, which featu…
View article: Stereoselective preparation of quaternary 2-vinyl sphingosines and ceramides and their effect on basal sphingolipid metabolism
Stereoselective preparation of quaternary 2-vinyl sphingosines and ceramides and their effect on basal sphingolipid metabolism Open