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View article: Quantification of the aperture modulation in radiotherapy treatment plans
Quantification of the aperture modulation in radiotherapy treatment plans Open
Background Many international guidelines, including those from the American Association of Physicists in Medicine (AAPM), emphasize the importance of quantifying plan modulation and recommend clearly documenting the modulation amount and r…
View article: Radiotherapy quality assurance for the PEACE 1 trial: An individual case review analysis
Radiotherapy quality assurance for the PEACE 1 trial: An individual case review analysis Open
gov: NCT01957436.
View article: Intrafraction motion in intra-cranial multi-target stereotactic radiosurgery plans: A multi-institutional investigation on robustness
Intrafraction motion in intra-cranial multi-target stereotactic radiosurgery plans: A multi-institutional investigation on robustness Open
SRS plans with lower complexity, in particular larger mean multi-leaf collimator (MLC) gap and MLC aperture irregularity, were shown to improve plan robustness to intrafraction patient motion.
View article: Studying the prevalence of ApoE Haplotypes in the Caribbean Hispanics from Puerto Rico
Studying the prevalence of ApoE Haplotypes in the Caribbean Hispanics from Puerto Rico Open
Background Among different ethnic groups, Hispanics rank second in Alzheimer’s disease (AD) prevalence. However, most studies on this condition have been conducted in Europeans. To address this bias in representation we interviewed and col…
View article: Multi-institutional investigation into the robustness of intra-cranial multi-target stereotactic radiosurgery plans to patient setup errors
Multi-institutional investigation into the robustness of intra-cranial multi-target stereotactic radiosurgery plans to patient setup errors Open
A higher level of importance should be directed towards plan complexity when considering plan robustness. It is recommended when planning multi-target SRS, larger MLC gaps and lower MLC aperture irregularity be considered during plan optim…
View article: Incorporating plan complexity into the statistical process control of volumetric modulated arc therapy pre‐treatment verifications
Incorporating plan complexity into the statistical process control of volumetric modulated arc therapy pre‐treatment verifications Open
Background Statistical process control (SPC) is a powerful statistical tool for process monitoring that has been highly recommended in healthcare applications, including radiation therapy quality assurance (QA). The AAPM TG‐218 report desc…
View article: A radiotherapy community data‐driven approach to determine which complexity metrics best predict the impact of atypical TPS beam modeling on clinical dose calculation accuracy
A radiotherapy community data‐driven approach to determine which complexity metrics best predict the impact of atypical TPS beam modeling on clinical dose calculation accuracy Open
Purpose To quantify the impact of treatment planning system beam model parameters, based on the actual spread in radiotherapy community data, on clinical treatment plans and determine which complexity metrics best describe the impact beam …
View article: Multileaf collimator characterization and modeling for a 1.5 T MR-linac using static synchronous and asynchronous sweeping gaps
Multileaf collimator characterization and modeling for a 1.5 T MR-linac using static synchronous and asynchronous sweeping gaps Open
Objective. The Elekta unity MR-linac delivers step-and-shoot intensity modulated radiotherapy plans using a multileaf collimator (MLC) based on the Agility MLC used on conventional Elekta linacs. Currently, details of the physical Unity ML…
View article: Multi‐institutional investigation into the robustness of intra‐cranial multi‐target stereotactic radiosurgery plans to delivery errors
Multi‐institutional investigation into the robustness of intra‐cranial multi‐target stereotactic radiosurgery plans to delivery errors Open
Background The use of modulated techniques for intra‐cranial stereotactic radiosurgery (SRS) results in highly modulated fields with small apertures, which may be susceptible to uncertainties in the delivery device. Purpose This study aime…
View article: Universal evaluation of MLC models in treatment planning systems based on a common set of dynamic tests
Universal evaluation of MLC models in treatment planning systems based on a common set of dynamic tests Open
The feasibility of using a common set of tests to assess MLC models in TPSs was demonstrated. Measurements within MLC types were very similar, but TPS dose calculations showed large variations. Standardisation of the MLC configuration in T…
View article: Improving the modeling of the Agility multi-leaf collimator
Improving the modeling of the Agility multi-leaf collimator Open
Robust fine tuning of multi-leaf collimator (MLC) Treatment Planning System (TPS) modeling parameters is crucial for creating an optimal beam model, particularly with the ever-increasing accuracy required for advancing techniques. Challeng…
View article: Dataset related to article "Multicentric evaluation of a machine learning model to streamline the radiotherapy patient specific quality assurance process"
Dataset related to article "Multicentric evaluation of a machine learning model to streamline the radiotherapy patient specific quality assurance process" Open
This record contains raw data related to article “Multicentric evaluation of a machine learning model to streamline the radiotherapy patient specific quality assurance process" Purpose: Patient-specific quality assurance (PSQA) is performe…
View article: Dataset related to article "Multicentric evaluation of a machine learning model to streamline the radiotherapy patient specific quality assurance process"
Dataset related to article "Multicentric evaluation of a machine learning model to streamline the radiotherapy patient specific quality assurance process" Open
This record contains raw data related to article “Multicentric evaluation of a machine learning model to streamline the radiotherapy patient specific quality assurance process" Purpose: Patient-specific quality assurance (PSQA) is performe…
View article: Intraoperative electron radiation therapy after salvage surgery in gynecological cancers and retroperitoneal sarcomas: outcomes and adverse effects
Intraoperative electron radiation therapy after salvage surgery in gynecological cancers and retroperitoneal sarcomas: outcomes and adverse effects Open
IOERT could have a role in the treatment of retroperitoneal sarcomas in primary tumors after EBRT, as it may suggest a benefit in local control or recurrences after surgical resection in those at high risk of microscopic residual disease. …
View article: Challenges in modeling the Agility multileaf collimator in treatment planning systems and current needs for improvement
Challenges in modeling the Agility multileaf collimator in treatment planning systems and current needs for improvement Open
Background The Agility multileaf collimator (MLC) mounted in Elekta linear accelerators features some unique design characteristics, such as large leaf thickness, eccentric curvature at the leaf tip, and defocused leaf sides (‘tilting'). T…
View article: Tetraploidy-Associated Genetic Heterogeneity Confers Chemo-Radiotherapy Resistance to Colorectal Cancer Cells
Tetraploidy-Associated Genetic Heterogeneity Confers Chemo-Radiotherapy Resistance to Colorectal Cancer Cells Open
Tetraploidy, or whole-genome duplication, is a common phenomenon in cancer and preludes chromosome instability, which strongly correlates with disease progression, metastasis, and treatment failure. Therefore, it is reasonable to hypothesi…
View article: A novel procedure for determining the optimal MLC configuration parameters in treatment planning systems based on measurements with a Farmer chamber
A novel procedure for determining the optimal MLC configuration parameters in treatment planning systems based on measurements with a Farmer chamber Open
Modelling of the multi-leaf collimator (MLC) in treatment planning systems (TPS) is crucial for the dose calculation accuracy of intensity-modulated radiation therapy plans. However, no standardised methodology for their configuration exis…
View article: On the need for tuning the dosimetric leaf gap for stereotactic treatment plans in the Eclipse treatment planning system
On the need for tuning the dosimetric leaf gap for stereotactic treatment plans in the Eclipse treatment planning system Open
The dosimetric leaf gap (DLG) and tongue‐and‐groove (T&G) effects are critical aspects in the modeling of multileaf collimators (MLC) in the treatment planning system (TPS). In this study, we investigated the dosimetric impact of limitatio…
View article: MRI in medical practice and its future use in radiation oncology. Resume of XXV GOCO Congress (Montpellier) 2017
MRI in medical practice and its future use in radiation oncology. Resume of XXV GOCO Congress (Montpellier) 2017 Open
This publication is a resume of the GOCO Congress (Montpellier 2017). A part of this congress was about the use of MRI in clinical practice, focused on the oncology field. The role of this tool was described in diagnosis, staging of tumors…
View article: Treatment plan complexity does not predict IROC Houston anthropomorphic head and neck phantom performance
Treatment plan complexity does not predict IROC Houston anthropomorphic head and neck phantom performance Open
Previous works indicate that intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) plans that are highly complex may produce more errors in dose calculation and treatment delivery. Multiple complexity metrics …
View article: Is anti-inflammatory radiotherapy an effective treatment in trochanteritis?
Is anti-inflammatory radiotherapy an effective treatment in trochanteritis? Open
Low-dose anti-inflammatory radiation may be used in the treatment of the recurrent cases of relapse or no response of trochanteritis to conventional treatments, with a high probability of remission of pain. These preliminary results indica…
View article: Hypofractionated 3D radiotherapy for inoperable T1-3 N0-1 non-small-cell lung cancer
Hypofractionated 3D radiotherapy for inoperable T1-3 N0-1 non-small-cell lung cancer Open
OBJECTIVE: This study assessed the toxicity and clinical outcomes of three-dimensional (3D) hypofractionated radiotherapy (HFRT) for medically inoperable T1-3 N0-1 non-small-cell lung cancer (NSCLC). METHODS: 34 patients with inoperable ea…