Jörg C. Prinz
YOU?
Author Swipe
View article: Down-Regulation of HLA-C Expression on Melanocytes May Contribute to the Therapeutic Efficacy of UVB Phototherapy in Psoriasis
Down-Regulation of HLA-C Expression on Melanocytes May Contribute to the Therapeutic Efficacy of UVB Phototherapy in Psoriasis Open
UVB phototherapy effectively treats psoriasis. Although it suppresses both innate and adaptive immunity, it remains unclear why UVB irradiation is primarily effective for T-cell-mediated but not inflammatory skin diseases of other etiologi…
View article: Revisiting the Need for mRNA Nucleoside Modification in CAR T Cell Engineering
Revisiting the Need for mRNA Nucleoside Modification in CAR T Cell Engineering Open
mRNA-based chimeric antigen receptor (CAR)-T cells offer the promise of enhanced safety and simplified manufacturing. However, in vitro-transcribed (IVT) mRNA is known to trigger antiviral immune responses, inflammatory signaling, and apop…
View article: Generalized pustular psoriasis of the ‘von Zumbusch’-type: a sepsis mimic with low PCT values
Generalized pustular psoriasis of the ‘von Zumbusch’-type: a sepsis mimic with low PCT values Open
View article: Multiple environmental antigens may trigger autoimmunity in psoriasis through T-cell receptor polyspecificity
Multiple environmental antigens may trigger autoimmunity in psoriasis through T-cell receptor polyspecificity Open
Introduction Psoriasis is a T-cell mediated autoimmune skin disease. HLA-C*06:02 is the main psoriasis-specific risk gene. Using a Vα3S1/Vβ13S1 T-cell receptor (TCR) from a lesional psoriatic CD8 + T-cell clone we had discovered that, as a…
View article: 002 Gene flow from archaic hominins causes psoriasis, ankylosing spondylitis, and Behçet's disease
002 Gene flow from archaic hominins causes psoriasis, ankylosing spondylitis, and Behçet's disease Open
View article: Global consensus on the clinical course, treatment and management of generalized pustular psoriasis (GPP)
Global consensus on the clinical course, treatment and management of generalized pustular psoriasis (GPP) Open
View article: Immunogenic self-peptides - the great unknowns in autoimmunity: Identifying T-cell epitopes driving the autoimmune response in autoimmune diseases
Immunogenic self-peptides - the great unknowns in autoimmunity: Identifying T-cell epitopes driving the autoimmune response in autoimmune diseases Open
HLA-associated autoimmune diseases likely arise from T-cell-mediated autoimmune responses against certain self-peptides from the broad HLA-presented immunopeptidomes. The limited knowledge of the autoimmune target peptides has so far compr…
View article: Generalized pustular psoriasis: A global Delphi consensus on clinical course, diagnosis, treatment goals and disease management
Generalized pustular psoriasis: A global Delphi consensus on clinical course, diagnosis, treatment goals and disease management Open
Background Generalized pustular psoriasis (GPP) is a rare and highly heterogeneous skin disease, characterized by flares of neutrophilic pustules and erythema. As a rare disease with few clinical studies and no standardized management appr…
View article: Prevalence, comorbidities and mortality of generalized pustular psoriasis: A literature review
Prevalence, comorbidities and mortality of generalized pustular psoriasis: A literature review Open
Generalized pustular psoriasis (GPP) is a rare auto‐inflammatory skin disease characterised by acute episodes of sterile pustule formation. Diagnosis and treatment of the disease have historically been complicated by a lack of awareness, a…
View article: International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis
International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis Open
Importance A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the t…
View article: „Freude und Freundschaft durch Forschung“
„Freude und Freundschaft durch Forschung“ Open
View article: ERAP1 Controls the Autoimmune Response against Melanocytes in Psoriasis by Generating the Melanocyte Autoantigen and Regulating Its Amount for HLA-C*06:02 Presentation
ERAP1 Controls the Autoimmune Response against Melanocytes in Psoriasis by Generating the Melanocyte Autoantigen and Regulating Its Amount for HLA-C*06:02 Presentation Open
Autoimmune diseases develop when autoantigens activate previously quiescent self-reactive lymphocytes. Gene–gene interaction between certain HLA class I risk alleles and variants of the endoplasmic reticulum aminopeptidase ERAP1 controls t…
View article: Lesional activation of T <sub>c</sub> 17 cells in Behçet disease and psoriasis supports HLA class I‐mediated autoimmune responses*
Lesional activation of T <sub>c</sub> 17 cells in Behçet disease and psoriasis supports HLA class I‐mediated autoimmune responses* Open
In BD, the genetic predisposition may mediate antigen-specific activation and differentiation of a Tc 17 response, possibly targeting endothelial (auto)antigens. Neutrophils recruited by IL-17A in this process may enhance tissue…
View article: Genetic Analysis of MPO Variants in Four Psoriasis Subtypes in Patients from Germany
Genetic Analysis of MPO Variants in Four Psoriasis Subtypes in Patients from Germany Open
View article: Dermatologische Fortbildung in Corona-Zeiten und danach
Dermatologische Fortbildung in Corona-Zeiten und danach Open
View article: Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases
Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases Open
View article: Psoriasis pustulosa und Chamäleon Syphilis
Psoriasis pustulosa und Chamäleon Syphilis Open
View article: Psoriasis bei Dupilumab-behandeltem atopischem Ekzem
Psoriasis bei Dupilumab-behandeltem atopischem Ekzem Open
View article: The Woronoff Ring in Psoriasis and the Mechanisms of Postinflammatory Hypopigmentation
The Woronoff Ring in Psoriasis and the Mechanisms of Postinflammatory Hypopigmentation Open
The Woronoff ring is a ring-like hypopigmentation zone around regressing psoriasis lesions. Although it was first described more than 100 years ago, its aetiology has remained a mystery. Recent insights into the pathogenesis of psoriasis c…
View article: Clonality of CD4+ Blood T Cells Predicts Longer Survival With CTLA4 or PD-1 Checkpoint Inhibition in Advanced Melanoma
Clonality of CD4+ Blood T Cells Predicts Longer Survival With CTLA4 or PD-1 Checkpoint Inhibition in Advanced Melanoma Open
Recognition of cancer antigens drives the clonal expansion of cancer-reactive T cells, which is thought to contribute to restricted T-cell receptor (TCR) repertoires in tumor-infiltrating lymphocytes (TILs). To understand how tumors escape…
View article: Intracellular Streptococcal Uptake and Persistence: A Potential Cause of Erysipelas Recurrence
Intracellular Streptococcal Uptake and Persistence: A Potential Cause of Erysipelas Recurrence Open
Erysipelas is a severe streptococcal infection of the skin primarily spreading through the lymphatic vessels. Penicillin is the treatment of choice. The most common complication consists in relapses which occur in up to 40% or more of pati…
View article: Renal clearance and intracellular half-life essentially determine methotrexate toxicity: A case series
Renal clearance and intracellular half-life essentially determine methotrexate toxicity: A case series Open
View article: Dr. Jörg Christoph Prinz
Dr. Jörg Christoph Prinz Open
Jörg C. Prinz is Full Professor of Dermatology and Venereology at the Clinic for Dermatology and Allergology of the Ludwig-Maximilian University (LMU) in Munich, Germany. He graduated with a medical degree from the University of Innsbruck …
View article: Human Leukocyte Antigen-Class I Alleles and the Autoreactive T Cell Response in Psoriasis Pathogenesis
Human Leukocyte Antigen-Class I Alleles and the Autoreactive T Cell Response in Psoriasis Pathogenesis Open
Psoriasis is a complex immune-mediated inflammatory skin disease characterized by T-cell-driven epidermal hyperplasia. It occurs on a strong genetic predisposition. The human leukocyte antigen (HLA)-class I allele HLA-C*06:02 on pso…
View article: Unopposed IL-36 Activity Promotes Clonal CD4+ T-Cell Responses with IL-17A Production in Generalized Pustular Psoriasis
Unopposed IL-36 Activity Promotes Clonal CD4+ T-Cell Responses with IL-17A Production in Generalized Pustular Psoriasis Open
View article: Entwicklung und Validierung eines neuen Zuweiserfragebogens für Psoriasisarthritis
Entwicklung und Validierung eines neuen Zuweiserfragebogens für Psoriasisarthritis Open
Einleitung: Die korrekte Zuweisung von Psoriasisarthritis-Patienten durch erstversorgende Dermatologen stellt im klinischen Alltag eine Herausforderung dar. Methoden: Anhand der Caspar-Kriterien wurde ein Fragebogen entwickelt, bei dem fol…
View article: The genetic basis for most patients with pustular skin disease remains elusive
The genetic basis for most patients with pustular skin disease remains elusive Open
The identification of IL36RN mutation carriers harbouring additional rare variants in CARD14 or AP1S3 indicates a more complex mode of inheritance of pustular psoriasis. Our results suggest that, in heterozygous IL36RN mutation carriers, t…
View article: Autoimmune aspects of psoriasis: Heritability and autoantigens
Autoimmune aspects of psoriasis: Heritability and autoantigens Open
Chronic immune-mediated disorders (IMDs) constitute a major health burden. Understanding IMD pathogenesis is facing two major constraints: Missing heritability explaining familial clustering, and missing autoantigens. Pinpointing IMD risk …
View article: The role of <scp>IL</scp>‐23 and the <scp>IL</scp>‐23/<scp>T<sub>H</sub></scp>17 immune axis in the pathogenesis and treatment of psoriasis
The role of <span>IL</span>‐23 and the <span>IL</span>‐23/<span>T<sub>H</sub></span>17 immune axis in the pathogenesis and treatment of psoriasis Open
Psoriasis is a chronic, immune‐mediated disease affecting more than 100 million people worldwide and up to 2.2% of the UK population. The aetiology of psoriasis is thought to originate from an interplay of genetic, environmental, infectiou…
View article: CTLA4 as Immunological Checkpoint in the Development of Multiple Sclerosis
CTLA4 as Immunological Checkpoint in the Development of Multiple Sclerosis Open
We investigated a patient who developed multiple sclerosis (MS) during treatment with the CTLA4‐blocking antibody ipilimumab for metastatic melanoma. Initially he showed subclinical magnetic resonance imaging (MRI) changes (radiologically …