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View article: Maternal body composition and the placental-fetal unit under maternal high-fat feeding partially improve by metformin treatment or lifestyle interventions during pregnancy in a mouse model
Maternal body composition and the placental-fetal unit under maternal high-fat feeding partially improve by metformin treatment or lifestyle interventions during pregnancy in a mouse model Open
Although all tested interventions had beneficial effects on the mother and the placental-fetal unit, NI seems to be most promising. Our findings highlight that preventive strategies for women with obesity should aim for pre-counseling advi…
View article: Fetal Growth Restriction. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/080, October 2024)
Fetal Growth Restriction. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/080, October 2024) Open
Purpose The purpose of this official guideline, updated and published by the German Society for Gynecology (Deutsche Gesellschaft für Gynäkologie und Geburtshilfe, DGGG) and coordinated by the joint guidelines program of the DGGG, Austrian…
View article: “A word that describes it well is ‘lonely’” – Experiencing preterm birth during the first COVID-19 lockdown in Germany: A qualitative study
“A word that describes it well is ‘lonely’” – Experiencing preterm birth during the first COVID-19 lockdown in Germany: A qualitative study Open
It is crucial to include scientific, pediatric expertise in future pandemic response planning to rapidly visualize and prevent negative consequences of mitigations measures, such as those described in this study. Protecting elements of fam…
View article: Kidney lipid metabolism: impact on pediatric kidney diseases and modulation by early-life nutrition
Kidney lipid metabolism: impact on pediatric kidney diseases and modulation by early-life nutrition Open
Our review summarizes and evaluates the current state of knowledge on lipid metabolism in relation to the pathomechanisms of kidney disease with a focus on common pediatric kidney diseases. In addition, we discuss how nutrition in early ch…
View article: Perspectives and involvement of children and adolescents during the decision-making process of their Covid-19 vaccination
Perspectives and involvement of children and adolescents during the decision-making process of their Covid-19 vaccination Open
Our study highlights the need to include young people`s perspectives in vaccine research, -development and -education campaigns. Future research should develop instruments to structurally embed and promote children and youth participation …
View article: The expanding clinical and genetic spectrum of <i>DYNC1H1</i>-related disorders
The expanding clinical and genetic spectrum of <i>DYNC1H1</i>-related disorders Open
Intracellular trafficking involves an intricate machinery of motor complexes, including the dynein complex, to shuttle cargo for autophagolysosomal degradation. Deficiency in dynein axonemal chains, as well as cytoplasmic light and interme…
View article: Exploring adolescent mental health during the COVID-19 crisis – strengths and difficulties
Exploring adolescent mental health during the COVID-19 crisis – strengths and difficulties Open
Introduction The SARS-CoV-2 pandemic has significantly impacted children and adolescents, leading to mental health challenges. Knowledge on their resources and difficulties is crucial and there is a need for valid instruments to assess the…
View article: Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae
Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae Open
Intrauterine growth restriction (IUGR) and being small for gestational age (SGA) are two distinct conditions with different implications for short- and long-term child development. SGA is present if the estimated fetal or birth weight is b…
View article: Intrauterine Growth Restriction: Improving Diagnostic Accuracy and the Role of Oxidative Stress in Neonatal and Long-Term Sequels
Intrauterine Growth Restriction: Improving Diagnostic Accuracy and the Role of Oxidative Stress in Neonatal and Long-Term Sequels Open
Intrauterine growth restriction (IUGR) and being born small for gestational age (SGA) are two distinct conditions with different implications for child development. IUGR is associated with greater perinatal morbidity and mortality and can …
View article: Maternal Exercise during Pregnancy Impacts Motor Performance in 9-Year-Old Children: A Pilot Study
Maternal Exercise during Pregnancy Impacts Motor Performance in 9-Year-Old Children: A Pilot Study Open
The benefits of maternal physical activity during pregnancy are well documented, but long-term effects on the child have been less studied. Therefore, we conducted a pilot follow-up study of a lifestyle intervention during pregnancy that a…
View article: Safety of SARS-CoV-2 test-to-stay in daycare: a regression discontinuity in time analysis
Safety of SARS-CoV-2 test-to-stay in daycare: a regression discontinuity in time analysis Open
Background and Objectives Test-to-stay concepts apply serial testing of children in daycare after exposure to SARS-CoV-2 without use of quarantine. This study aims to assess safety of a test-to-stay screening in daycare facilities. Methods…
View article: Effect of Lifestyle Interventions during Pregnancy on Maternal Leptin, Resistin and Offspring Weight at Birth and One Year of Life
Effect of Lifestyle Interventions during Pregnancy on Maternal Leptin, Resistin and Offspring Weight at Birth and One Year of Life Open
Lifestyle during pregnancy impacts the health of the mother and child. However, the extent to which physical activity affects maternal biomarkers and factors that might influence birth weight remains unclear. We analysed data from two life…
View article: Perinatal Obesity Sensitizes for Premature Kidney Aging Signaling
Perinatal Obesity Sensitizes for Premature Kidney Aging Signaling Open
Chronic Kidney Disease (CKD), a global health burden, is strongly associated with age-related renal function decline, hypertension, and diabetes, which are all frequent consequences of obesity. Despite extensive studies, the mechanisms det…
View article: Additional file 1 of CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia
Additional file 1 of CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia Open
Additional file 1.
View article: Infection and transmission risks of COVID-19 in schools and their contribution to population infections in Germany: A retrospective observational study using nationwide and regional health and education agency notification data
Infection and transmission risks of COVID-19 in schools and their contribution to population infections in Germany: A retrospective observational study using nationwide and regional health and education agency notification data Open
Background School-level infection control measures in Germany during the early Coronavirus Disease 2019 (COVID-19) pandemic differed across the 16 federal states and lacked a dependable evidence base, with available evidence limited to reg…
View article: Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life
Maternal and perinatal obesity induce bronchial obstruction and pulmonary hypertension via IL-6-FoxO1-axis in later life Open
Obesity is a pre-disposing condition for chronic obstructive pulmonary disease, asthma, and pulmonary arterial hypertension. Accumulating evidence suggests that metabolic influences during development can determine chronic lung diseases (C…
View article: Implementing the Lolli-Method and pooled RT-qPCR testing for SARS-CoV-2 surveillance in schools: a pilot project
Implementing the Lolli-Method and pooled RT-qPCR testing for SARS-CoV-2 surveillance in schools: a pilot project Open
Purpose School closures have been used as part of lockdown strategies to contain the spread of SARS-CoV-2, adversely affecting children’s health and education. To ensure the accessibility of educational institutions without exposing societ…
View article: Effective high-throughput RT-qPCR screening for SARS-CoV-2 infections in children
Effective high-throughput RT-qPCR screening for SARS-CoV-2 infections in children Open
Systematic SARS-CoV-2 testing is a valuable tool for infection control and surveillance. However, broad application of high sensitive RT-qPCR testing in children is often hampered due to unpleasant sample collection, limited RT-qPCR capaci…
View article: Metformin Prevents Key Mechanisms of Obesity-Related Complications in Visceral White Adipose Tissue of Obese Pregnant Mice
Metformin Prevents Key Mechanisms of Obesity-Related Complications in Visceral White Adipose Tissue of Obese Pregnant Mice Open
With the gaining prevalence of obesity, related risks during pregnancy are rising. Inflammation and oxidative stress are considered key mechanisms arising in white adipose tissue (WAT) sparking obesity-associated complications and diseases…
View article: Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response, Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice
Perinatal Obesity Induces Hepatic Growth Restriction with Increased DNA Damage Response, Senescence, and Dysregulated Igf-1-Akt-Foxo1 Signaling in Male Offspring of Obese Mice Open
Maternal obesity predisposes for hepato-metabolic disorders early in life. However, the underlying mechanisms causing early onset dysfunction of the liver and metabolism remain elusive. Since obesity is associated with subacute chronic inf…
View article: Treatment of high fat diet‐induced obese pregnant mice with IL‐6 receptor antibody does not ameliorate placental function and fetal growth restriction
Treatment of high fat diet‐induced obese pregnant mice with IL‐6 receptor antibody does not ameliorate placental function and fetal growth restriction Open
Problem : Pregnancy complications and adverse birth outcomes are in part fueled by the rise in obesity and its associated co‐morbidities in western societies. Fetal healthy development and placental function are disturbed by an obese, infl…
View article: Impact of Diet Quality during Pregnancy on Gestational Weight Gain and Selected Adipokines—Results of a German Cross-Sectional Study
Impact of Diet Quality during Pregnancy on Gestational Weight Gain and Selected Adipokines—Results of a German Cross-Sectional Study Open
While nutrition during pregnancy is critical for the health of both mother and child, little is known about the diet quality of women during pregnancy, its correlation with gestational weight gain (GWG)/body composition, and chosen materna…
View article: Applicability of predictive models for 30-day unplanned hospital readmission risk in paediatrics: a systematic review
Applicability of predictive models for 30-day unplanned hospital readmission risk in paediatrics: a systematic review Open
Objectives To summarise multivariable predictive models for 30-day unplanned hospital readmissions (UHRs) in paediatrics, describe their performance and completeness in reporting, and determine their potential for application in practice. …
View article: Effective high-throughput RT-qPCR screening for SARS-CoV-2 infections in children
Effective high-throughput RT-qPCR screening for SARS-CoV-2 infections in children Open
Systematic SARS-CoV-2 testing is a valuable tool for infection control and surveillance. However, broad application of high sensitive RT-qPCR testing in children is often hampered due to unpleasant sample collection, limited RT-qPCR capaci…