Jörg Fuchs
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View article: Hybridity of mainly asexually propagating duckweeds in genus <i>Lemna</i> – dead end or breakthrough?
Hybridity of mainly asexually propagating duckweeds in genus <i>Lemna</i> – dead end or breakthrough? Open
Summary The cosmopolitan, mainly vegetatively propagating, organ‐reduced monocotyledonous aquatic duckweeds are the smallest and fastest growing angiosperms, distributed world‐wide and flower rarely in nature. Recently, we reported intra‐ …
View article: Children and Adolescents With Localised Non‐Rhabdomyosarcoma Soft Tissue Sarcoma: Results of the CWS‐96 and CWS‐2002P Prospective Trials With Reclassification of the Trial Data Incorporating the Recent Soft Tissue Sarcoma Registry
Children and Adolescents With Localised Non‐Rhabdomyosarcoma Soft Tissue Sarcoma: Results of the CWS‐96 and CWS‐2002P Prospective Trials With Reclassification of the Trial Data Incorporating the Recent Soft Tissue Sarcoma Registry Open
Background Here we report the results of the first comprehensive European trials for all soft tissue sarcoma entities, which aimed to develop a new risk stratification system, limit radiotherapy and chemotherapy for low‐/standard‐risk pati…
View article: Population‐wide single‐pollen nuclei genotyping in rye sheds light on the genetic basis and environmental plasticity of meiotic recombination
Population‐wide single‐pollen nuclei genotyping in rye sheds light on the genetic basis and environmental plasticity of meiotic recombination Open
Summary The core molecular machinery of meiosis is conserved deep across eukaryotic lineages. Nevertheless, recombination landscapes vary at multiple scales, from chromosomes to populations, caused by an interaction between genetic and env…
View article: R-Spondin1 Regulates Fate of Enteric Neural Progenitors via Differential LGR4/5/6 Expression in Mice and Humans
R-Spondin1 Regulates Fate of Enteric Neural Progenitors via Differential LGR4/5/6 Expression in Mice and Humans Open
View article: Hybridity of mainly asexually propagating duckweeds in genus <i>Lemna</i> - dead end or breakthrough?
Hybridity of mainly asexually propagating duckweeds in genus <i>Lemna</i> - dead end or breakthrough? Open
Summary The cosmopolitan, mainly vegetatively propagating, organ-reduced monocotyledonous aquatic duckweeds are the smallest and fastest growing angiosperms, distributed world-wide and flower rarely in nature. Recently, we reported intra- …
View article: Minimal Invasive Duodenal Atresia Repair – Does Surgical Technique of Anastomosis Matter? A Systematic Review and Meta-analysis
Minimal Invasive Duodenal Atresia Repair – Does Surgical Technique of Anastomosis Matter? A Systematic Review and Meta-analysis Open
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View article: Shedding light on the embryo:endosperm balance diversity that pseudogamy can achieve in the polyploid apomictic Psidium cattleyanum (Myrtaceae, Myrteae)
Shedding light on the embryo:endosperm balance diversity that pseudogamy can achieve in the polyploid apomictic Psidium cattleyanum (Myrtaceae, Myrteae) Open
Apomixis is defined as the asexual mode of reproduction through seeds. Nearly all gametophytic apomictic species are polyploid. Psidium cattleyanum , a polyploid species with various described ploidy levels, exhibits apomixis and requires …
View article: A haplotype-resolved pangenome of the barley wild relative Hordeum bulbosum
A haplotype-resolved pangenome of the barley wild relative Hordeum bulbosum Open
View article: Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis
Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis Open
View article: Kinetochore mutations and histone phosphorylation pattern changes preceded holo- and macro-monocentromere evolution
Kinetochore mutations and histone phosphorylation pattern changes preceded holo- and macro-monocentromere evolution Open
Centromeres are essential for kinetochore assembly and spindle attachment. While chromosomes of most species are monocentric with a single centromere, a minority exhibit holocentricity, with a centromere along the chromatid length. Sporadi…
View article: Colorectal Carcinoma in Childhood and Adolescence: Microsatellite Instability Correlates With a Favorable Prognosis
Colorectal Carcinoma in Childhood and Adolescence: Microsatellite Instability Correlates With a Favorable Prognosis Open
Background Colorectal cancer (CRC) accounts for 10% of cancer cases worldwide; however, pediatric CRC is extremely rare, with an annual incidence of one to two cases per million. Microsatellite instability (MSI) has been shown to play a re…
View article: Distinct pathways for genetic and epigenetic predisposition in familial and bilateral Wilms tumor
Distinct pathways for genetic and epigenetic predisposition in familial and bilateral Wilms tumor Open
View article: Kinetochore mutations and histone phosphorylation pattern changes preceded holo- and macro-monocentromere evolution
Kinetochore mutations and histone phosphorylation pattern changes preceded holo- and macro-monocentromere evolution Open
Summary Centromeres are essential for kinetochore assembly and spindle attachment. While chromosomes of most species are monocentric with a single centromere, a minority exhibit holocentricity, with a centromere along the chromatid length.…
View article: CRISPR-CISH: an in situ chromogenic DNA repeat detection system for research and life science education
CRISPR-CISH: an in situ chromogenic DNA repeat detection system for research and life science education Open
In situ hybridization is a technique to visualize specific DNA sequences within nuclei and chromosomes. Various DNA in situ fluorescent labeling methods have been developed, which typically involve global DNA denaturation prior to the prob…
View article: Does chromoanagenesis play a role in the origin of B chromosomes?
Does chromoanagenesis play a role in the origin of B chromosomes? Open
B chromosomes (Bs) exist in addition to the standard (A) chromosomes in a wide range of species. The process underlying their origin is still unclear. We propose pathways of intra- and interspecific origin of B chromosomes based on known m…
View article: European standard clinical practice recommendations for children and adolescents with Rhabdomyosarcoma a joint EpSSG, CWS and ERN PaedCan project
European standard clinical practice recommendations for children and adolescents with Rhabdomyosarcoma a joint EpSSG, CWS and ERN PaedCan project Open
Rhabdomyosarcoma (RMS) is a heterogeneous group of malignancies with specific histopathological characteristics. Distinct molecular findings help to classify RMS into PAX::FOXO1 fusion gene positive and fusion gene negative subtypes. Furth…
View article: Genome diversity and evolution of the duckweed section <i>Alatae</i> comprising diploids, polyploids, and interspecific hybrids
Genome diversity and evolution of the duckweed section <i>Alatae</i> comprising diploids, polyploids, and interspecific hybrids Open
SUMMARY The section Alatae of genus Lemna of the monocotyledonous aquatic duckweed family (Lemnaceae) consists of rather diverse accessions with unknown phylogeny and unclear taxonomic assignment. In contrast to other duckweeds, some Alata…
View article: Pollen and anther morphological variation in rye was shaped by domestication
Pollen and anther morphological variation in rye was shaped by domestication Open
View article: Nephron‐Sparing Surgery for Patients With Wilms Tumor, a Surgical Delphi Study Consensus Statement
Nephron‐Sparing Surgery for Patients With Wilms Tumor, a Surgical Delphi Study Consensus Statement Open
Background and Aim Current pediatric renal tumor treatment protocols allow for nephron‐sparing surgery (NSS) for unilateral disease only under strict conditions. Oncological guidelines do not account for surgical feasibility, however, poss…
View article: Triploidy is prominent in the duckweed <i>Lemna minor</i> complex
Triploidy is prominent in the duckweed <i>Lemna minor</i> complex Open
Duckweeds (Lemnaceae Martinov) are aquatic monocotyledonous flowering plants comprising five genera and 35 recognized species, known for being the smallest and fastest-growing flowering plants on Earth. Many species are morphologically ind…
View article: CRISPR-CISH: An <i>in situ</i> chromogenic DNA repeat detection system for research and life science education
CRISPR-CISH: An <i>in situ</i> chromogenic DNA repeat detection system for research and life science education Open
In situ hybridization is a technique to visualize specific DNA sequences within nuclei and chromosomes. Various DNA in situ fluorescent labeling methods have been developed, which typically involve global DNA denaturation prior to the prob…
View article: Gametophytic degradation of CENH3 - a synthetic biology approach for haploid induction in plants
Gametophytic degradation of CENH3 - a synthetic biology approach for haploid induction in plants Open
Double haploid technology is a critical tool for accelerating plant breeding. The manipulation of centromere-specific histone H3 (CENH3) has previously been shown to induce haploid progeny in both the model plant Arabidopsis and certain cr…
View article: Genome diversity and phylogeny of the section <i>Alatae</i> of genus <i>Lemna</i>(Lemnaceae), comprising the presumed species <i>Lemna aequinoctialis, Le. perpusilla</i> and <i>Le. aoukikusa</i>
Genome diversity and phylogeny of the section <i>Alatae</i> of genus <i>Lemna</i>(Lemnaceae), comprising the presumed species <i>Lemna aequinoctialis, Le. perpusilla</i> and <i>Le. aoukikusa</i> Open
Summary The Section Alatae of genus Lemna of the monocotyledonous aquatic duckweed family (Lemnaceae) consists of rather diverse accessions with unknown phylogeny and unclear taxonomic assignment. In contrast to other duckweeds, some Alata…
View article: Wilms tumor primary cultures capture phenotypic heterogeneity and facilitate preclinical screening
Wilms tumor primary cultures capture phenotypic heterogeneity and facilitate preclinical screening Open
Wilms tumors (WT) are characterized by variable contributions of blastemal, epithelial and stromal elements, reflecting their diverse cellular origins and genetic drivers. In vitro models remain rare, despite a growing need to better chara…
View article: The genetic mechanism of B chromosome drive in rye illuminated by chromosome-scale assembly
The genetic mechanism of B chromosome drive in rye illuminated by chromosome-scale assembly Open
View article: The potential of ALFA-tag and tyramide-based fluorescence signal amplification to expand the CRISPR-based DNA imaging toolkit
The potential of ALFA-tag and tyramide-based fluorescence signal amplification to expand the CRISPR-based DNA imaging toolkit Open
Understanding the spatial organization of genomes within chromatin is crucial for deciphering gene regulation. A recently developed CRISPR–dCas9-based genome labeling tool, known as CRISPR–FISH, allows efficient labeling of repetitive sequ…
View article: Mechanical forces orchestrate the metabolism of the developing oilseed rape embryo
Mechanical forces orchestrate the metabolism of the developing oilseed rape embryo Open
Summary The initial free expansion of the embryo within a seed is at some point inhibited by its contact with the testa, resulting in its formation of folds and borders. Although less obvious, mechanical forces appear to trigger and accele…
View article: Application of ALFA-tag and tyramide-based fluorescence signal amplification to expand the CRISPR-based DNA imaging toolkit v1
Application of ALFA-tag and tyramide-based fluorescence signal amplification to expand the CRISPR-based DNA imaging toolkit v1 Open
Understanding the spatial organization of genomes within chromatin is crucial for deciphering gene regulation. In this protocol we describe application of an ALFA-tagged dCas9 protein in combination with aA. thaliana centromere-specific gR…
View article: Centromere sequence-independent but biased loading of subgenome-specific CENH3 variants in allopolyploid Arabidopsis suecica
Centromere sequence-independent but biased loading of subgenome-specific CENH3 variants in allopolyploid Arabidopsis suecica Open
View article: Major chromosome rearrangements in intergeneric wheat × rye hybrids in compatible and incompatible crosses detected by GBS read coverage analysis
Major chromosome rearrangements in intergeneric wheat × rye hybrids in compatible and incompatible crosses detected by GBS read coverage analysis Open